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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Waterpipe Smoking Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

NCT02147665
View directory record Official record
Conditions
Hookah Smoking
Interventions
Hookah smoking
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 39 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study of Hookah Café Customers in the Atlanta Area

NCT05916170
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Health Warnings, No Warnings
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
977 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reactions to Warnings on Hookah Ads

NCT03723616
View directory record Official record
Conditions
Reactions to Warnings, Hookah Smoking
Interventions
Ads Only, Ads with text-only health warning labels (HWLs), Ads with text + graphic health warning labels (HWLs)
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 34 Years
Enrollment
2,588 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Impact of Waterpipe Tobacco Flavors on Waterpipe Smoking Intentions, Perceptions, Patterns, and Toxicant Exposure

NCT03232827
View directory record Official record
Conditions
Smoking, Hookah, Waterpipe Smoking
Interventions
Flavored-Sweetened Waterpipe Tobacco, Unflavored-sweetened waterpipe tobacco, Unflavored-very low sweetened waterpipe tobacco, Flavored-very low sweetened waterpipe
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 23, 2019 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Role of Contingency Management in Waterpipe Smoking Cessation

NCT02159092
View directory record Official record
Conditions
Waterpipe Smoking
Interventions
Contingency Management
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Text and Pictorial Waterpipe Tobacco Warnings Among Young Adults

NCT05783843
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Pictorial Warnings, Text Warnings, No Warnings (Control)
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 29 Years
Enrollment
1,215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 6, 2026, 3:26 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

NCT03616002
View directory record Official record
Conditions
Hookah Smoking
Interventions
Hookah smoking
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 29 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding the Effect of Flavor on Hookah Smoking Experience

NCT03589599
View directory record Official record
Conditions
Waterpipe Smoking
Interventions
Flavored tobacco, Non-flavored tobacco
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 30 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Consumer Perceptions of Waterpipe Tobacco Packaging and Digital Marketing Claims

NCT05439421
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Package/Advertisement With Claim, Package/Advertisement Without Claim
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 29 Years
Enrollment
1,507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Concurrent Hookah and Alcohol Consumption on Smoking Topography and Toxicant Exposure

NCT03096860
View directory record Official record
Conditions
Alcohol Use, Unspecified, Hookah Smoking
Interventions
Active alcohol consumption, Placebo consumption
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing and Pilot Testing an Intervention to Reduce Household Shisha Smoke Exposure Within Somali Homes

NCT06316947
View directory record Official record
Conditions
Shisha
Interventions
CHW-delivered intervention
Radiation
Lead sponsor
University of Minnesota
Other
Eligibility
6 Months and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adverse Health Effects of Mainstream and Secondhand Hookah Smoke in NYC Hookah Bars

NCT02638194
View directory record Official record
Conditions
COPD
Interventions
Active smoking of Tobacco Hookah for 2 hours, Exposure to tobacco hookah second hand smoke, Visit a win bar
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 22, 2015 · Synced Sep 6, 2026, 3:26 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function

NCT03166787
View directory record Official record
Conditions
Smoking, Endothelial Dysfunction
Interventions
Charcoal hookah, E-coal hookah, Cigarette, Carbon Monoxide inhalation, Room Air inhalation, vitamin C, tadalafil
Other · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
21 Years to 49 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Hookah and Cigarette Smoking

NCT00992550
View directory record Official record
Conditions
Smoking
Interventions
Cigarette, Hookah
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Electronic Hookah and Endothelial Cell Function

NCT04133376
View directory record Official record
Conditions
Smoking, Endothelial Dysfunction
Interventions
Electronic hookah vaping with nicotine, Electronic hookah vaping without nicotine
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 6, 2026, 3:26 AM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

NCT02310373
View directory record Official record
Conditions
Nicotine-free Hookah Smoking
Interventions
Nicotine free hookah smoking
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 39 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 6, 2026, 3:26 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol

NCT04661683
View directory record Official record
Conditions
Hookah Smoking, Secondhand Aerosol, Vascular Stiffness, Vaping
Interventions
Combustible Hookah Smoke, Electronic Hookah Aerosol, Clean Room Air
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing Toxicity of Waterpipe Tobacco Smoking

NCT03253653
View directory record Official record
Conditions
Waterpipe Smoking
Interventions
Differential effects of waterpipe smoking practices on toxicity of waterpipe tobacco smoke
Device
Lead sponsor
San Diego State University
Other
Eligibility
21 Years and older
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing and Testing Waterpipe-specific Health Warning Labels

NCT05317663
View directory record Official record
Conditions
Waterpipe Smoking, Health Warning Label, Harm Perception, Puffing Behaviour, Quitting Smoking, Health Risk Behaviors
Interventions
Test Health Warning Label (HWL), Test without Health Warning Label (no-HWL)
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing Risk Messages for Waterpipe Tobacco Cessation in Young Adults

NCT03595280
View directory record Official record
Conditions
Hookah Smoking
Interventions
Hookah tobacco risk messages
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 30 Years
Enrollment
349 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Waterpipe Size on Smoking Behavior and Exposures

NCT05705375
View directory record Official record
Conditions
Waterpipe Size
Interventions
Waterpipe size
Other
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
21 Years to 39 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Cardiovascular Effects of Electronic Hookah Vaping

NCT03690427
View directory record Official record
Conditions
Endothelial Dysfunction, Inflammation, Oxidative Stress
Interventions
Traditional hookah smoking, Electronic hookah vaping
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 39 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Sep 6, 2026, 3:26 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Alternate Nicotine Delivery Systems and Airway Epithelial Biology

NCT01974063
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 2, 2018 · Synced Sep 6, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Brief Tobacco Intervention in the US Military

NCT03196102
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Smoking, Cigar, Smoking, Pipe, Smoking, Hookah, Nicotine Dependence
Interventions
BTI, Cigarette smoking military tailored pamphlet, Standard smoking cessation intervention
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
2,999 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 6, 2026, 3:26 AM EDT