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Showing 1–24 of 310 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Weakness Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial Comparing Traditional Pelvic Floor Rehabilitation to Pilates in Increasing Pelvic Muscles Strength.

NCT00549458
View directory record Official record
Conditions
Muscle Weakness
Interventions
Pilates, Pelvic muscle rehabilitation therapy
Behavioral · Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2009 · Synced Jul 21, 2026, 10:51 AM EDT
Completed No phase listed Observational

A RETROspective Study of Patients With TK2d

NCT03701568
View directory record Official record
Conditions
Thymidine Kinase 2 (TK2)
Interventions
dC/dT
Drug
Lead sponsor
Zogenix MDS, Inc.
Industry
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Jul 21, 2026, 10:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Dual Task Perturbation Training for OAwMCI

NCT04938349
View directory record Official record
Conditions
Mild Cognitive Impairment, Old Age; Debility
Interventions
Dual task perturbation training
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
55 Years and older
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 21, 2026, 10:51 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Influence of Directional Preference on Movement Coordination Deficits in Individuals With Whiplash Associated Disorders

NCT06143228
View directory record Official record
Conditions
Whiplash Injury of Cervical Spine, Muscle Weakness
Interventions
Not listed
Lead sponsor
D'Youville College
Other
Eligibility
19 Years to 70 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Tallahassee, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Jul 21, 2026, 10:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy

NCT04234282
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity, Knee Pain Swelling, Muscle Weakness, Muscle Weakness Condition, Power
Interventions
Manual Physical Therapy
Procedure
Lead sponsor
Jennifer Moreno Clinic
Other
Eligibility
45 Years to 74 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

Strength Testing After Nitrate Delivery (STAND) in ICU Patients

NCT02293616
View directory record Official record
Conditions
Respiratory Failure
Interventions
Nitrate Rich Beetroot Juice, Placebo
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
56 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Jul 21, 2026, 10:51 AM EDT
Active, not recruiting Not applicable Interventional

Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study

NCT06119087
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular Diseases
Interventions
Mechanical insufflation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

eStimCycle: Early Rehabilitation in Critical Care

NCT02214823
View directory record Official record
Conditions
Intensive Care Unit Acquired Weakness (ICUAW)
Interventions
FES-Cycling, Standard Care
Device · Other
Lead sponsor
Associate Professor Sue Berney PhD, BPT
Other
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jul 21, 2026, 10:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

NCT06129110
View directory record Official record
Conditions
Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity, Insulin Resistance
Interventions
Diet Weight Loss
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 21, 2026, 10:51 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Project 4A: Inspiratory Muscle Training and Diaphragm Strength

NCT02367170
View directory record Official record
Conditions
Sepsis
Interventions
Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP), Inspiratory Muscle Strength Training (IMST), SHAM Inspiratory Muscle Strength Training (IMST), Diaphragm thickness measurement, Blood and Urine samples
Procedure · Drug · Device + 1 more
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

A Pilot Study of Rehabilitation Among Intensive Care Unit (ICU) Survivors: the RETURN Trial

NCT00715494
View directory record Official record
Conditions
Brain Injury, Muscle Weakness
Interventions
Cognitive, physical, and functional rehabilitation
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 100 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD)

NCT03359473
View directory record Official record
Conditions
Cachexia
Interventions
GSK2881078, Matching Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
50 Years to 75 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
5
States / cities
Torrance, California • Jacksonville, Florida • High Point, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Activity Intervention Tailored for Rural Men

NCT05460637
View directory record Official record
Conditions
Physical Inactivity, Sedentary Behavior, Weak; Muscle
Interventions
No BS just Fitness
Behavioral
Lead sponsor
Jacob Gallagher
Other
Eligibility
18 Years to 80 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

Early Mobilization in the ICU

NCT01777035
View directory record Official record
Conditions
Respiratory Failure
Interventions
early PT OT
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 20, 2022 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis

NCT00125658
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
Control, Experimental
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of INDUS810 on Body Composition, Muscular Performance, and Training Adaptations

NCT03850106
View directory record Official record
Conditions
Weakness, Muscle
Interventions
Placebo, Indus810
Dietary Supplement
Lead sponsor
The Center for Applied Health Sciences, LLC
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Stow, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older

NCT02191982
View directory record Official record
Conditions
Cancer, Geriatric, Fatigue
Interventions
Walk With Ease
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Firdapse for Post-BOTOX Vocal Weakness

NCT05123053
View directory record Official record
Conditions
Vocal Weakness(Post-BOTOX Injection)
Interventions
Amifampridine
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jul 21, 2026, 10:51 AM EDT
Withdrawn Phase 2 Interventional

Source of Hand Weakness After Stroke

NCT00907829
View directory record Official record
Conditions
Stroke, Cerebrovascular Accident
Interventions
lidocaine, muscle stimulator
Drug · Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
30 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2014 · Synced Jul 21, 2026, 10:51 AM EDT
Completed No phase listed Observational

Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain

NCT01862731
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 10:51 AM EDT
Completed No phase listed Observational

Muscle Dysfunction in Critical Illness

NCT03717831
View directory record Official record
Conditions
Critical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle Weakness
Interventions
Observational study of standard of care
Other
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years and older
Enrollment
66 participants
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Jul 21, 2026, 10:51 AM EDT
Completed Phase 4 Interventional Results available

Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery

NCT03923556
View directory record Official record
Conditions
Kidney Transplant; Complications, Postoperative Residual Curarization, Postoperative Residual Weakness
Interventions
Sugammadex, Neostigmine
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jul 21, 2026, 10:51 AM EDT
Withdrawn Not applicable Interventional

Improving Muscle Function in Nutritionally at Risk, Elderly Patients

NCT03071354
View directory record Official record
Conditions
Muscle Weakness, ICU-acquired Weakness
Interventions
HMB protein supplement (3g), Nutritional Supplement
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Jul 21, 2026, 10:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.

NCT07699562
View directory record Official record
Conditions
ICU Acquired Weakness
Interventions
TetraGraph, Electromyography, Nerve conduction studies
Device
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 21, 2026, 10:51 AM EDT