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Showing 1–24 of 1,882 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Weight Reduction Clear all
Completed Phase 1 Interventional

Endoscopic Gastric Reduction for Weight Management

NCT01682733
View directory record Official record
Conditions
Obesity
Interventions
Botulinum toxin, Overstitch Endoscopic Suturing System
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 3 Interventional Results available

Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3)

NCT01395914
View directory record Official record
Conditions
Cachexia, Non-Small Cell Lung Cancer
Interventions
Anamorelin HCl, Placebo
Drug
Lead sponsor
Helsinn Therapeutics (U.S.), Inc
Industry
Eligibility
18 Years and older
Enrollment
513 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
19
States / cities
Corona, California • Fountain Valley, California • Fullerton, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Safety and Effectiveness of Low and High Carbohydrate Diets

NCT00079547
View directory record Official record
Conditions
Obesity
Interventions
Low-calorie diet, low-carbohydrate diet
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
3
States / cities
Denver, Colorado • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2013 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

fMRI and Appetite-Related Hormones Pre and Post Obesity Surgery

NCT01583725
View directory record Official record
Conditions
Obesity
Interventions
Liquid meal responses, fMRI responses to food-cues
Procedure · Behavioral
Lead sponsor
New York Obesity and Nutrition Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Improving Behavioral Weight Loss Via Electronic Handheld Device

NCT01241578
View directory record Official record
Conditions
Obesity
Interventions
Lifestyle Counseling
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 2Phase 3 Interventional

A Randomized Trial Comparing Two Doses of Portion-Controlled Foods Within a Primary Care Weight Loss Program

NCT00907660
View directory record Official record
Conditions
Obesity
Interventions
Weight loss counseling, Portion-Controlled Foods
Behavioral · Dietary Supplement
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 29, 2020 · Synced Sep 13, 2026, 4:36 PM EDT
Terminated Not applicable Interventional Results available

Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation

NCT03607500
View directory record Official record
Conditions
Kidney Transplant; Complications, Glomerular Disease, Weight Gain, Kidney Transplant
Interventions
caloric intake reduction
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lose Now North Carolina Community Weight Loss Program

NCT01615471
View directory record Official record
Conditions
Obesity
Interventions
Group weight loss with companion internet
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Sep 13, 2026, 4:36 PM EDT
Completed No phase listed Observational

Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery

NCT03855878
View directory record Official record
Conditions
Monoclonal Gammopathy of Undetermined Significance
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
30 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remote Weight Management Program for Obese Women

NCT05635097
View directory record Official record
Conditions
Weight Loss
Interventions
Motivational Interviewing counseling on the Mediterranean diet and weight checks at regular intervals
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2023 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Study of the Carbon Dioxide Treatment for Fat Reduction

NCT00974415
View directory record Official record
Conditions
Overweight
Interventions
CO2, Sham
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Small Changes Weight Loss Program and Message Dissemination Via Facebook in Chicago's West Side

NCT03614338
View directory record Official record
Conditions
Obesity
Interventions
Small changes weight loss program
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Maintenance-Tailored Obesity Treatment

NCT00670462
View directory record Official record
Conditions
Obesity
Interventions
Standard Behavioral Treatment (SBT), Maintenance-Tailored Treatment (MTT)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of a Ketogenic Diet on Body Weight and Cardiovascular Risk Factors

NCT00498394
View directory record Official record
Conditions
Obesity
Interventions
Clinical diet trial
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older · Female only
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2002
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 9, 2007 · Synced Sep 13, 2026, 4:36 PM EDT
Terminated Phase 2 Interventional Results available

Megestrol Acetate in Treating Weight Loss or Anorexia in Young Patients With Malignancies Who Are Undergoing Radiation Therapy and/or Chemotherapy

NCT01200602
View directory record Official record
Conditions
Anorexia, Weight Changes
Interventions
megestrol acetate, clinical observation
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 21 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Sep 13, 2026, 4:36 PM EDT
Terminated Phase 2 Interventional Results available

The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition

NCT00686972
View directory record Official record
Conditions
Bariatric Surgery
Interventions
GLP-1
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 4 Interventional

Adjustable Gastric Banding and Its Effects on Postprandial Glucose Metabolism Independent of Weight Loss

NCT01094054
View directory record Official record
Conditions
Obesity, Diabetes
Interventions
Adjustable gastric banding, Dietary and lifestyle modification
Procedure · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Sep 13, 2026, 4:36 PM EDT
Terminated No phase listed Observational

Pilot Project for Cardiopulmonary and Functional Evaluation in Patients With Pancreatic Cancer Associated Cachexia

NCT02580422
View directory record Official record
Conditions
Cachexia, Pancreatic Cancer
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Sep 13, 2026, 4:36 PM EDT
Recruiting Not applicable Interventional

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

NCT06325722
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Low-carbohydrate Diet, Low-fat Diet
Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rethinking Eating and FITness for Men

NCT01843595
View directory record Official record
Conditions
Weight Loss, Overweight
Interventions
REFIT Intervention
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 20, 2014 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 3 Interventional

A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight

NCT06131437
View directory record Official record
Conditions
Obesity
Interventions
Cagrilintide, Semaglutide, Tirzepatide
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
809 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
46
States / cities
Birmingham, Alabama • Montgomery, Alabama • Costa Mesa, California + 39 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study for Collaborate2Lose

NCT05646771
View directory record Official record
Conditions
Obesity
Interventions
Partner support
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 17, 2023 · Synced Sep 13, 2026, 4:36 PM EDT
Active, not recruiting Not applicable Interventional

Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Groups After TBI

NCT05699772
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Telehealth-delivered Group Lifestyle Balance for people with TBI (tGLB-TBI), Brain Health Group (BHG)
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2025 · Synced Sep 13, 2026, 4:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Engaging Motivation for the Prevention of Weight Regain

NCT01169428
View directory record Official record
Conditions
Obesity
Interventions
Mindfulness Based Weight Loss Maintenance (MBWLM), Behavioral: Standard Behavioral Weight-Loss Maintenence
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
2
States / cities
Durham, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 13, 2013 · Synced Sep 13, 2026, 4:36 PM EDT