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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:04 AM EDT

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Showing 25–48 of 151 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Wound Healing Complication Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Nu-3 Topical Gel for Treatment of Diabetic Foot Ulcer

NCT05276401
View directory record Official record
Conditions
Chronic Diabetic Foot Ulcers
Interventions
5% Bisphosphocin Topical Gel, Placebo Topical Gel, 10% Bisphosphocin Topical Gel
Drug
Lead sponsor
Lakewood-Amedex Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
5
States / cities
Jonesboro, Arkansas • Fresno, California • South Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Oct 20, 2026, 4:04 AM EDT
Not listed Phase 2 Interventional

Safety and Efficacy of HO/03/03 10μg in the Treatment of Plantar Neuropathic Diabetic Foot Ulcers

NCT00926068
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
HO/03/03 10µg, Placebo
Drug
Lead sponsor
HealOr
Industry
Eligibility
18 Years to 80 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
19
States / cities
Phoenix, Arizona • Castro Valley, California • Long Beach, California + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 20, 2026, 4:04 AM EDT
Terminated Phase 4 Interventional Results available

Motorized Continuous Cold Therapy Versus Standard Post-op Icing Protocol for Two Foot and Ankle Procedures

NCT00950183
View directory record Official record
Conditions
Narcotic Consumption, Pain, Wound Healing, Patient Satisfaction
Interventions
Iceman® Cold Therapy unit (djOrtho), Ice
Device · Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 20, 2026, 4:04 AM EDT
Not listed No phase listed Observational

Negative Pressure Wound Therapy Registry

NCT02467998
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Surgical Wound Dehiscence, Burns, Other Types of Chronic Non Healing Wounds
Interventions
NPWT
Device
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Oct 20, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

Use of Negative Pressure Wound Therapy in Morbidly Obese Women After Cesarean Delivery

NCT03269968
View directory record Official record
Conditions
Obesity, Morbid, Wound Infection, Wound Complication
Interventions
Negative pressure wound therapy (PREVENA Incision Management Therapy System), Standard dressing
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 20, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

Sternal Plating High Risk

NCT06660186
View directory record Official record
Conditions
Heart Diseases
Interventions
Rigid Sternal Fixation, Wire Cerclage
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation to Accelerate Wound Healing

NCT03821675
View directory record Official record
Conditions
Diabetes, Diabetic Foot Ulcer, Peripheral Neuropathy, Peripheral Arterial Disease
Interventions
Electrical Stimulation - Active, Electrical Stimulation - Sham
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery

NCT03887299
View directory record Official record
Conditions
Cesarean Section Complications, Wound Breakdown, Wound Infection, Satisfaction, Surgical Wound Infection
Interventions
ReliaTect™ Post-Op Dressing (contains chlorohexidine gluconate or CHG), Standard Wound Care
Combination Product · Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 20, 2026, 4:04 AM EDT
Recruiting Phase 3 Interventional

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

NCT06337292
View directory record Official record
Conditions
Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication, Wound Dehiscence
Interventions
Incisional Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Baltimore, Maryland • Lebanon, New Hampshire • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients

NCT02309944
View directory record Official record
Conditions
Postoperative Complications, Obesity, Gynecologic Neoplasms
Interventions
Standard Wound Closure, Prevena™ Incision Management System
Procedure · Device
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Oct 20, 2026, 4:04 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects

NCT03548610
View directory record Official record
Conditions
Wound of Skin, Non-melanoma Skin Cancer, Skin Graft Complications, Wound of Lower Leg, Wound of Knee
Interventions
Nanofat-seeded biological scaffold on surgical defect
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 20, 2026, 4:04 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Non-Invasive Testing to Evaluate Wound Healing in Diabetes

NCT04232631
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
SnapshotNIR, Kent Imaging
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 20, 2026, 4:04 AM EDT
Not listed No phase listed Observational

Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds

NCT03880188
View directory record Official record
Conditions
Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries, Skull Fractures, Surgical Wound, Surgical Wound Infection, Wound Healing, Disturbance of Wound Healing, Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Complication, Wound Dehiscence, Wound of Skin, Wound Open, Wounds, Penetrating, Wounds, Nonpenetrating, Wounds
Interventions
Not listed
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 16, 2022 · Synced Oct 20, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

Prospective Evaluation of Infectious Vulvovaginitis on Wound Complication Rates After Vulvar Excision for Premalignant Lesions

NCT06070454
View directory record Official record
Conditions
Vaginitis, Vulvar Diseases
Interventions
Vaginitis panel
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Use of Spinal Sealant System During Spinal Surgery

NCT00458354
View directory record Official record
Conditions
Spine Surgery, Excessive Repair, Spinal Cord Injuries, Complication of Surgical Procedure
Interventions
Spinal Sealant, Standard Methods of Closing of the Dura
Device · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2011 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

PICO Breast Reduction Clinical Study Looking at Incision Healing Complications

NCT01640366
View directory record Official record
Conditions
Delayed Healing
Interventions
PICO
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
3
States / cities
Chicago, Illinois • The Bronx, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2020 · Synced Oct 20, 2026, 4:04 AM EDT
Terminated Not applicable Interventional

Acupuncture and Post-Surgical Wound Healing

NCT00260494
View directory record Official record
Conditions
Postoperative Complications, Surgical Wound Infection, Surgical Wound Dehiscence
Interventions
acupuncture, sham acupuncture
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2013 · Synced Oct 20, 2026, 4:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.

NCT04746573
View directory record Official record
Conditions
Non-healing Wounds
Interventions
Natrox Topical Oxygen Therapy
Device
Lead sponsor
Inotec AMD Limited
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 20, 2026, 4:04 AM EDT
Completed Phase 2 Interventional

Efficacy Study of a Bioelectric Dressing Used With Negative Pressure Wound Therapy to Treat Diabetic and Pressure Ulcers

NCT01022216
View directory record Official record
Conditions
Wound Healing
Interventions
Procellera™ Wound Dressing with V.A.C.® Therapy, V.A.C.® Therapy
Device
Lead sponsor
Vomaris Innovations
Industry
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2012 · Synced Oct 20, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

Closed Incision Negative Pressure Wound Therapy vs. Foam as Post Operative Dressing

NCT05427916
View directory record Official record
Conditions
Diabetes, Morbid Obesity, Lymphedema, Orthopedic Disorder
Interventions
Avance Solo, Optifoam
Device · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 20, 2026, 4:04 AM EDT
Completed No phase listed Observational

Wound Complications in Head and Neck Surgery

NCT03134976
View directory record Official record
Conditions
Hypothyroidism; Surgery, Head and Neck Cancer, Wound Heal, Laryngeal Cancer, Laryngeal Fistula
Interventions
Levothyroxine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2020 · Synced Oct 20, 2026, 4:04 AM EDT
Active, not recruiting No phase listed Observational

Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing

NCT07375160
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
Interventions
dHPT, AIC
Biological
Lead sponsor
Cellution Biologics
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 20, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

CLOSM Trial: Groin Closure Using Layered Option for Suture Material

NCT06990425
View directory record Official record
Conditions
Vascular Diseases
Interventions
Groin closure with PDS suture, Groin closure suture material
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 20, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

Improvement in Wound Healing With Negative Pressure Wound Therapy for Postoperative Total Hip Arthroplasty

NCT02355691
View directory record Official record
Conditions
Complications; Arthroplasty, Infection or Inflammation, Wound Complication
Interventions
PREVENA
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 20, 2026, 4:04 AM EDT