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ClinicalTrials.gov public records Last synced Oct 20, 2026, 9:41 PM EDT

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Showing 73–96 of 278 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Wrinkles Clear all
Completed Phase 4 Interventional Results available

The Treatment of Glabellar Frown Lines

NCT02096081
View directory record Official record
Conditions
Glabellar Frown Lines
Interventions
IncobotulinumtoxinA, OnabotulinumtoxinA
Drug
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
10
States / cities
Los Angeles, California • Sacramento, California • Santa Monica, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Oct 20, 2026, 9:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Determine Effectiveness of Activation Mist on Facial Skin Wrinkles

NCT01939964
View directory record Official record
Conditions
Skin Wrinkles on Face and Neck Areas
Interventions
Activation Mist
Other
Lead sponsor
California Allergy and Asthma Medical Group, Inc.
Other
Eligibility
30 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2013 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Four Injectable Neuromodulators in the Glabella Area Glabella Area

NCT05167864
View directory record Official record
Conditions
Cosmetic Techniques
Interventions
Onabotulinumtoxina for Injection, Abobotulinumtoxina for Injection, IncobotulinumtoxinA for Injection, PrabotulinumtoxinA for Injection
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 65 Years · Female only
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 17, 2025 · Synced Oct 20, 2026, 9:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluating the Safety and Effectiveness of the Tixel Fractional System in the Treatment of Photodamage at Low Settings

NCT05182502
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel
Device
Lead sponsor
Eric Bernstein, MD
Other
Eligibility
25 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ardmore, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines

NCT01189747
View directory record Official record
Conditions
Lateral Canthus Rhytides, Crow's Feet Lines
Interventions
onabotulinumtoxinA, normal saline
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
446 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated May 7, 2019 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

A Study of Octave System for Improving Lines and Wrinkles of the Décolleté

NCT04681352
View directory record Official record
Conditions
Décolleté Wrinkles
Interventions
Octave-Ultherapy treatment
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
10
States / cities
Beverly Hills, California • San Mateo, California • Norwalk, Connecticut + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 20, 2026, 9:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Peri-orbital and Peri-oral Wrinkle Reduction Trial

NCT01981252
View directory record Official record
Conditions
Peri-orbital Wrinkles, Peri-oral Wrinkles
Interventions
Ulthera® System Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
5
States / cities
Beverly Hills, California • Laguna Beach, California • Englewood, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2017 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of Increasing Doses of DaxibotulinumtoxinA for Injection (DAXI for Injection) in the Treatment of Moderate or Severe Lateral Canthal Lines

NCT03911102
View directory record Official record
Conditions
Lateral Canthal Lines
Interventions
DaxibotulinumtoxinA for injection
Biological
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
4
States / cities
Sacramento, California • Sarasota, Florida • Itasca, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Oct 20, 2026, 9:41 PM EDT
Terminated Not applicable Interventional

Study To Assess The Safety And Efficacy Of The Tempsure Flexsure Applicators For Abdominal Wrinkles

NCT04930705
View directory record Official record
Conditions
Wrinkle
Interventions
Treatment with TempSure Applicator
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2022 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.

NCT00765583
View directory record Official record
Conditions
Rhytids
Interventions
Restylane
Drug
Lead sponsor
Medicis Aesthetics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Chicago, Illinois • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2011 · Synced Oct 20, 2026, 9:41 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Comparison of AmnioFix Laser and Standard of Care Treatment

NCT02659124
View directory record Official record
Conditions
Rhytides
Interventions
AmnioFix plus Standard of Care, Standard of Care
Device · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Ulthera System for the Treatment of the Decolletage

NCT01713686
View directory record Official record
Conditions
Chest Wrinkles
Interventions
Ulthera System Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
35 Years to 70 Years · Female only
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
4
States / cities
Sacramento, California • San Diego, California • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of DaxibotulinumtoxinA (DAXI) for Injection for Treatment of Upper Facial Lines

NCT04259086
View directory record Official record
Conditions
Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Interventions
DaxibotulinumtoxinA for injection
Drug
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
6
States / cities
Manhattan Beach, California • San Diego, California • Santa Monica, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Oct 20, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles

NCT07222397
View directory record Official record
Conditions
Photodamaged Skin, Rhytids, Lines Skin, Wrinkles and Rhytides
Interventions
Laser Resurfacing
Device
Lead sponsor
FA Corporation
Industry
Eligibility
50 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health

NCT03769779
View directory record Official record
Conditions
Aging, Wrinkle, Skin Elasticity, Healthy, Hydration
Interventions
FloraGLO Lutein, Safflower Oil
Dietary Supplement
Lead sponsor
Kemin Foods LC
Industry
Eligibility
30 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Port Chester, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Oct 20, 2026, 9:41 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Study to Evaluate the Safety and Efficacy of Candela Technology

NCT06202274
View directory record Official record
Conditions
Hair Reduction, Tattoo Removal, Wrinkle, Acne, Scars, Benign Cutaneous Vascular Lesions, Skin Conditions
Interventions
Nordlys, Gentle, Picoway, Vbeam, Profound, Profound Matrix, eTwo, Exceed, CO2RE
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
2
States / cities
Jacksonville, Florida • Marlborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Safety and Efficacy of the Apollo™ System for Treatment of Wrinkles and Rhytides

NCT01283711
View directory record Official record
Conditions
Facelift
Interventions
apollo device
Device
Lead sponsor
Pollogen
Industry
Eligibility
35 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2013 · Synced Oct 20, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

CelluJuve® for the Treatment of Moderate to Severe NLFs

NCT07545980
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
CelluJuve®
Device
Lead sponsor
Spiderwort Biotechnologies Inc.
Industry
Eligibility
22 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 20, 2026, 9:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Efficacy Study for Magnetic Induction to Treat Wrinkles

NCT01701440
View directory record Official record
Conditions
Wrinkles and Rhytides
Interventions
Biofusionary Bebe
Device
Lead sponsor
Rocky Mountain Biosystems, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2012 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

NCT00968825
View directory record Official record
Conditions
Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions
Botulinum Toxin Type A, Placebo
Drug
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
30 Years to 60 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 19, 2013 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Cryo-Touch II for the Treatment of Wrinkles

NCT01167140
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Cryo-Touch II
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
30 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles

NCT04057768
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic, Wrinkle
Interventions
Venus Viva
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 20, 2026, 9:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Restylane Silk Microinjections to Cheeks

NCT03742479
View directory record Official record
Conditions
Wrinkle
Interventions
Restylane® Silk
Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 3, 2019 · Synced Oct 20, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Identify if Saie Beauty's Under Eye Concealer Works to Improve Under-Eye Skin Appearance and Reduce Imperfections

NCT05231681
View directory record Official record
Conditions
Wrinkle
Interventions
Saie Beauty's Hydrabeam Sheer Brightening Under Eye Concealer
Dietary Supplement
Lead sponsor
Saie Beauty
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 6, 2022 · Synced Oct 20, 2026, 9:41 PM EDT