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ClinicalTrials.gov public records Last synced Oct 13, 2026, 8:35 PM EDT

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Showing 241–264 of 308 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: (Bupivacaine Liposome Injectable Suspension) Clear all
Completed Phase 3 Interventional Results available

Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy

NCT04300231
View directory record Official record
Conditions
Cystectomy
Interventions
epidural bupivacaine 0.05%, Liposomal bupivacaine, bupivacaine 0.125%, bupivacaine 0.5%, /hydromorphone 0.05mg/ml, injectable saline
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 13, 2026, 8:35 PM EDT
Not listed Phase 4 Interventional

Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation

NCT03664986
View directory record Official record
Conditions
Vaginal Prolapse
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Oct 13, 2026, 8:35 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction

NCT02274077
View directory record Official record
Conditions
Hernia, Ventral
Interventions
EXPAREL, Normal Saline
Drug
Lead sponsor
Chester Mays
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 13, 2026, 8:35 PM EDT
Active, not recruiting Phase 2 Interventional Results available

Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After Surgery in Retroperitoneal Sarcoma Patients ("RESQU-SARC" Trial)

NCT04189783
View directory record Official record
Conditions
Retroperitoneal Sarcoma
Interventions
Liposomal Bupivacaine, Quadratus Lumborum Block, Questionnaire Administration
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 13, 2026, 8:35 PM EDT
Recruiting Not applicable Interventional

EOIFP Block Versus OSTAP Block for Upper Abdominal Surgery

NCT06409156
View directory record Official record
Conditions
Open Abdominal Surgery
Interventions
Oblique Subcostal Transversus Abdominis Plane Block, External Oblique Intercostal Fascial Plane block
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation

NCT04293809
View directory record Official record
Conditions
Breast Augmentation
Interventions
Exparel Injectable Product, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Oct 13, 2026, 8:35 PM EDT
Terminated Phase 3 Interventional Results available

Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel

NCT04826484
View directory record Official record
Conditions
Urologic Diseases, Hypospadias, Undescended Testes, Chordee, Hydrocele, Orchiectomy
Interventions
Exparel 133 miligrams per 10 milliliter injection, Bupivacaine Hydrochloride
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
6 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 26, 2023 · Synced Oct 13, 2026, 8:35 PM EDT
Terminated Not applicable Interventional Results available

Ultrasound Guided Local Infiltration Analgesia for Hip Arthroscopy

NCT01907191
View directory record Official record
Conditions
Hip Injuries
Interventions
liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Oct 13, 2026, 8:35 PM EDT
Completed No phase listed Observational

Comparison of Epidural and TAP Block in Abdominal Surgery

NCT01848951
View directory record Official record
Conditions
Acute Pain, Surgery, Regional Anesthesia
Interventions
Epidural, TAP Block
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 13, 2026, 8:35 PM EDT
Terminated Phase 4 Interventional

Use of Long-acting Bupivacaine In Lower Extremity Amputation

NCT04360421
View directory record Official record
Conditions
Amputation, Anesthesia, Local, Opioid Use
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Oct 13, 2026, 8:35 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty

NCT01977339
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Liposome Bupivacaine, Bupivacaine
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Results available

Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

NCT02199574
View directory record Official record
Conditions
Pain
Interventions
EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 2 Interventional Results available

Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma

NCT02749968
View directory record Official record
Conditions
Blunt Chest Wall Trauma, Rib Fracture, Sternal Fracture
Interventions
Liposomal bupivacaine, 0.9% sodium chloride
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction

NCT02189317
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Exparel
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 27, 2016 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain

NCT02959996
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Liposomal bupivacaine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Results available

Pecto-Intercostal Fascial Plane Block Study

NCT04928339
View directory record Official record
Conditions
Cardiac Surgery, Opioid Use, Unspecified
Interventions
Bupivacaine Injection, Liposomal bupivacaine, Saline
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 3 Interventional Results available

Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy

NCT01802411
View directory record Official record
Conditions
Posterolateral Thoracotomy, Postoperative Pain
Interventions
EXPAREL 266 mg, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
7
States / cities
Miami, Florida • Shreveport, Louisiana • Fargo, North Dakota + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 2 Interventional Results available

Parasternal Nerve Block in Cardiac Patients

NCT01826851
View directory record Official record
Conditions
Coronary Artery Disease, Pain, Postoperative
Interventions
Exparel, Placebo
Drug
Lead sponsor
Peter A Knight
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Results available

Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse

NCT02449915
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Bupivacaine, Placebo
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 8, 2017 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Results available

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B504

NCT01509807
View directory record Official record
Conditions
Retraction of Colostomy
Interventions
IV morphine sulfate or Sponsor-approved equivalent, EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
3
States / cities
Tucson, Arizona • Orlando, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Oct 13, 2026, 8:35 PM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Oct 13, 2026, 8:35 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular

NCT02242201
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
PNB Bupivacaine, PAI Ropivacaine, PAI liposomal bupivacaine, Epinephrine, Ketorolac
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 19, 2018 · Synced Oct 13, 2026, 8:35 PM EDT
Enrolling by invitation Phase 4 Interventional

Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

NCT07584915
View directory record Official record
Conditions
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
Procedure · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 13, 2026, 8:35 PM EDT
Recruiting Phase 2 Interventional

Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2

NCT05736549
View directory record Official record
Conditions
Total Knee Replacement, Knee Arthroplasty
Interventions
Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 13, 2026, 8:35 PM EDT