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ClinicalTrials.gov public records Last synced Oct 13, 2026, 7:13 PM EDT

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Showing 193–216 of 308 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: (Bupivacaine Liposome Injectable Suspension) Clear all
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery

NCT06806410
View directory record Official record
Conditions
Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation, Dupuytren Contracture, Finger Fracture, Wrist Arthropathy, Distal Radius Fracture
Interventions
Liposomal bupivacaine (LB), Dexamethasone
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery

NCT03080142
View directory record Official record
Conditions
Colorectal Surgery, TAP Blocks
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 90 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy

NCT02519023
View directory record Official record
Conditions
Acute Pain
Interventions
Liposomal Bupivacaine, Bupivacaine, Ultrasound, Epinephrine, acetaminophen, ibuprofen, Oxycodone
Drug · Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 8, 2019 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

Intercostal Nerve Cryoablation for Postoperative Pain Management

NCT03972397
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Intercostal Nerve Cryoablation, Bupivacaine liposomal injectable suspension, Patient-controlled analgesia (PCA)
Device · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional

Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty

NCT02863120
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
liposomal bupivacaine, bupivacaine HCl, Ropivacaine, Saline
Drug
Lead sponsor
Texas Orthopaedics, Sports and Rehabilitation Associates
Other
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery

NCT04333095
View directory record Official record
Conditions
Cardiovascular Surgery, Pain, Postoperative, Block
Interventions
Liposomal bupivacaine, Normal Saline Flush, 0.9% Injectable Solution_#1
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 1 Interventional

Liposomal Bupivacaine for Post-operative Pain Control in Adolescent Bariatric Patients

NCT06077214
View directory record Official record
Conditions
Bariatric Surgery Candidate, Post-operative Pain
Interventions
Treatment with liposomal bupivacaine, Treatment with standard bupivacaine
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
13 Years to 18 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery

NCT02219087
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Liposomal bupivacaine, Standard of Care
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Oct 13, 2026, 7:13 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

A Comparison of Exparel to Bupivacaine in TAP Block for Abdominal Gynecologic Surgery

NCT03304444
View directory record Official record
Conditions
Gynecologic Cancer, Post Operative Pain
Interventions
Bupivacaine, liposomal bupivacaine
Drug
Lead sponsor
Abington Memorial Hospital
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Abington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2017 · Synced Oct 13, 2026, 7:13 PM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Peripheral Nerve Block

NCT03922620
View directory record Official record
Conditions
Pain, Acute, Surgery, Anesthesia, Opioid Use
Interventions
Liposomal bupivacaine, Peripheral Nerve Block
Drug
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 13, 2026, 7:13 PM EDT
Not listed Phase 3 Interventional

Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction

NCT04764916
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair

NCT01801124
View directory record Official record
Conditions
Hernia
Interventions
EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Oct 13, 2026, 7:13 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Quality of Recovery From Mastectomy With and Without PECS Blocks

NCT05795413
View directory record Official record
Conditions
Post Operative Pain, Quality of Recovery After Mastectomy
Interventions
Mastectomy with PECS blocks, Liposomal bupivacaine
Procedure · Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 13, 2026, 7:13 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy Between Serratus Plane Block And Local Infiltration In Vats

NCT03642457
View directory record Official record
Conditions
Lung Cancer
Interventions
Bupivacaine, Bupivacaine liposome
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 13, 2026, 7:13 PM EDT
Terminated Phase 2 Interventional Results available

Exparel Interscalene vs Indwelling Catheter

NCT03827213
View directory record Official record
Conditions
Pain
Interventions
Exparel, Indwelling Interscalene Catheter
Drug · Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
40 Years to 74 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Oct 13, 2026, 7:13 PM EDT
Terminated Phase 4 Interventional Results available

Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients

NCT03638635
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Colectomy, Colorectal Surgery
Interventions
Bupivacaine, Bupivacaine liposome
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
6
States / cities
Alexandria, Virginia • Fairfax, Virginia • Falls Church, Virginia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Adductor Canal Block Versus Liposomal Bupivacaine in TKA

NCT04086186
View directory record Official record
Conditions
Total Knee Arthroplasty, Post-operative Pain Control
Interventions
Liposomal Bupivacaine Peri-articular Injection, Adductor canal block
Procedure
Lead sponsor
Good Samaritan Regional Medical Center, Oregon
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Oct 13, 2026, 7:13 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Study of Postsurgical Pain Control for Lower Extremity Fractures

NCT02214810
View directory record Official record
Conditions
Lower Extremity Fractures.
Interventions
Bupivacaine/Exparel
Drug
Lead sponsor
Broward Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 19, 2016 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

Adult Patients Undergoing Open Colectomy MA402S23B303

NCT01507246
View directory record Official record
Conditions
Bowel Obstruction
Interventions
IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension)
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Riverdale, Georgia
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 13, 2026, 7:13 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Exparel v Dexamethasone in RCR

NCT06575010
View directory record Official record
Conditions
Rotator Cuff Tears, Postoperative Pain
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Dexamethasone
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Results available

Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy

NCT03250507
View directory record Official record
Conditions
Hysterectomy
Interventions
Bupivacaine, Liposomal bupivacaine, Saline
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Hip Arthroscopy Pain Control Randomized Control Trial (RCT)

NCT02947178
View directory record Official record
Conditions
Hip Pain Chronic, Anesthesia, Bupivacaine
Interventions
Fascial iliac regional soft tissue infiltration blockade, Pain Score Survey, Pill Count, Bupivacaine, Liposomal Bupivacaine
Procedure · Behavioral · Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Liposomal Bupivacaine vs. Bupivacaine Hydrochloride and Lidocaine During Suburethral Sling Placement

NCT02875015
View directory record Official record
Conditions
Postoperative Pain
Interventions
Liposomal Bupivacaine, Bupivacaine Hydrochloride and Lidocaine, Suburethral Sling
Drug · Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
19 Years and older · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Morristown, New Jersey • Summit, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 13, 2026, 7:13 PM EDT
Completed Phase 4 Interventional

Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery

NCT06213454
View directory record Official record
Conditions
Analgesia, Surgery
Interventions
TAP Anesthesia, Surgeon-Initiated Local Anesthetic
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 13, 2026, 7:13 PM EDT