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Showing 1–8 of 8 matching trials from the live ClinicalTrials.gov search.
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Oral Hygiene Products in an In Situ Caries Model

NCT02399163
Conditions
Dental Caries
Interventions
Fluoride free toothpaste, Fluoride toothpaste, Fluoride mouthwash
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel

NCT06242444
Conditions
Tooth Erosion
Interventions
Experimental Dentifrice, Placebo Control Dentifrice, Reference Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste

NCT03296072
Conditions
Tooth Erosion
Interventions
0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers

New In Situ Model Design for Caries and Erosion

NCT07849270
Conditions
Caries, Erosive Tooth Wear
Interventions
0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste, Mandibular intraoral appliance
Drug · Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Completed Phase 2 Interventional Accepts healthy volunteers Results available

To Evaluate the Efficacy and Tolerability of Sodium Bicarbonate Toothpaste

NCT02207907
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate plus sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
247 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Las Vegas, Nevada
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate and sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Conditions
Dentin Sensitivity, Oral Hygiene
Interventions
Test Dentifrice, Reference Dentifrice (Aquafresh Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride

NCT01563172
Conditions
Dental Caries
Interventions
Sodium fluoride / silica and carbopol, 0.5g, Sodium fluoride / silica and carbopol, 1.5g, Fluoride free dentifrice
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Indianapolis, Indiana