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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:41 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 272 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: 12-weeks of Weight Loss Clear all

Conditions: Adolescent Obesity
Interventions: Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill, Placebo; Behavioral · Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 12 Years to 17 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Obesity
Interventions: Cagrilintide, Semaglutide, Placebo; Drug
Lead sponsor: Novo Nordisk A/S; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 7
States / cities: Costa Mesa, California • Plantation, Florida • Indianapolis, Indiana + 4 more

Conditions: Obesity, Sleep Apnea, Obstructive
Interventions: lifestyle intervention; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 696 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking, Body Weight
Interventions: Smoking Cessation, Smoking Cessation plus Weight Loss; Behavioral
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 35 Years
Enrollment: 330 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Obesity
Interventions: Nutrisystem; Behavioral
Lead sponsor: University of Kentucky; Other
Eligibility: 25 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Obesity, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
Interventions: Dietary Intervention, Educational Intervention, Laboratory Biomarker Analysis, Quality-of-Life Assessment; Dietary Supplement · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: Female only
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Duarte, California

Conditions: Overweight, Obesity
Interventions: RIDE e-health application; Behavioral
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Obesity, Pain
Interventions: Use of PDA + support to reduce weight and pain, MOVE! level 2 group weight loss counseling; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Hines, Illinois

Conditions: Diabetes, Chronic Disease, Psychological Distress
Interventions: Immediate Chronic Disease Prevention Program (CDPP), Workplace Equity, Job and Health Supports Employer Intervention, Delayed, attenuated Chronic Disease Prevention Program (CDPP); Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 64 Years
Enrollment: 455 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Endometrial Carcinoma, Obesity, EIN, Endometrial Intraepithelial Neoplasia, Endometrial Cancer Stage I
Interventions: CONCURRENT LAPAROSCOPIC HYSTERECTOMY AND WEIGHT LOSS SURGERY-Referral; Other
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Obesity, Depression
Interventions: vCare Intervention (6-month active treatment followed by 6-month maintenance), vCare Intervention (active treatment after 6 months); Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 50 Years to 74 Years
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • St Louis, Missouri

Conditions: Obesity
Interventions: CP-866,087, placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 4
States / cities: Orlando, Florida • Kalamazoo, Michigan • Portland, Oregon + 1 more

Conditions: Weight Loss
Interventions: Probiotics, Placebo; Dietary Supplement
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 151 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Pediatric Obesity
Interventions: Comprehensive behavioral weight control program, Individual 12-month nutrition education program; Behavioral · Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 10 Years to 14 Years
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obesity, Obesity; Drug, Lifestyle, Healthy
Interventions: Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG; Behavioral · Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 70 Years
Enrollment: 870 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 4
States / cities: Los Angeles, California • Saint Louis Park, Minnesota • Winston-Salem, North Carolina + 1 more

Conditions: Yoga, Obesity, Weight Loss
Interventions: Yoga + behavioral weight loss; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 55 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Obesity, Weight Loss
Interventions: Weight loss without pharmacotherapy; Other
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 40 Years and older
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Severe Obesity, Obesity, BMI Greater Than 30
Interventions: Tirzepatide, Standard of Care post-gastric bypass; Drug · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 25 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Obesity
Interventions: CMS-recommended lifestyle counseling, Liraglutide 3.0mg, Portion-Controlled Diet, Placebo Oral Tablet, Phentermine 15 MG, Extension Study CMS-recommended lifestyle counseling; Behavioral · Drug · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 70 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Blood Pressure, High Blood Pressure, Dietary Modification, Overweight and Obesity
Interventions: Self-Guided Approach, Dietitian-led Approach; Behavioral
Lead sponsor: Geisinger Clinic; Other
Eligibility: 18 Years and older
Enrollment: 187 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Danville, Pennsylvania • Wilkes-Barre, Pennsylvania

Conditions: Obesity
Interventions: MBL949, Placebo; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 4
States / cities: Miami, Florida • Morehead City, North Carolina • Knoxville, Tennessee + 1 more

Conditions: Obesity and Obesity-related Medical Conditions
Interventions: Mounjaro, Sleeve Gastrectomy; Drug · Procedure
Lead sponsor: Nicholas Skertich; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pediatric Obesity, Obesity
Interventions: Semaglutide; Drug
Lead sponsor: Erin Mauney; Other
Eligibility: 12 Years to 15 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sarcopenic Obesity
Interventions: Weight Loss and Weight Maintenance; Combination Product
Lead sponsor: University of Alaska Fairbanks; Other
Eligibility: 60 Years to 80 Years
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Fairbanks, Alaska

Search by objective public record fields.

SMART Use of Medication for the Treatment of Adolescent Severe Obesity

A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Pragmatic Obstructive Sleep Apnea Weight Loss Trial Assessing Effectiveness and Reach

Treating Adults at Risk for Weight Gain With Interactive Technology

The Effect of Nutrisystem Meal Provision on Weight

Pancreatic Nutritional Program for Weight Loss in Overweight/Obese Patients With Stage I-III Breast Cancer

Evaluation of the Remote Intervention for Diet and Exercise (RIDE)

PDA+: A Personal Digital Assistant for Obesity Treatment

NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

Study To Determine The Effects And Safety Of A Weight Loss Compound On Overweight, Otherwise Healthy, Volunteers

Use of Probiotics to Aid in Weight Loss

Bone Health of Obese Adolescents During Weight Loss

Long-term Effectiveness of the Antiobesity Medication Phentermine

Feasibility and Impact of Yoga in Obesity

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial

Lifestyle Modification and Liraglutide

Remote Dietary Counseling to Promote Healthy Diet and Blood Pressure

Study to Assess Safety, Tolerability and Efficacy of SC Administered MBL949 in Obese Participants With or Without T2DM

Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

Brain and Obesity Longitudinal Development: Neurobiological Mechanisms of Semaglutide Treatment of Adolescent Obesity

Nutritional Strategies for Metabolic Health in Aging