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ClinicalTrials.gov public records Last synced Oct 7, 2026, 3:26 AM EDT

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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: 2.5% lidocaine/2.5% prilocaine Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum Ointment

NCT03799484
View directory record Official record
Conditions
Forehead Rhytides, Forehead Wrinkles
Interventions
Botulinum toxin type A, 2.5% lidocaine/2.5% prilocaine, petrolatum ointment
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Oct 7, 2026, 3:26 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Lidocaine-Prilocaine Cream in Conjunction With Paracervical Block for Pain With Abortion

NCT03508804
View directory record Official record
Conditions
Pain
Interventions
Lidocaine-Prilocaine Cream, Placebo Cream, 1% Lidocaine Paracervical Block
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Oct 7, 2026, 3:26 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children

NCT01628874
View directory record Official record
Conditions
Lumbar Puncture, Topical Analgesia
Interventions
J-Tip, EMLA, Lidocaine
Device · Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 18 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 21, 2019 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 4 Interventional Results available

Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures

NCT04003012
View directory record Official record
Conditions
Leukemia-Lymphoma
Interventions
EMLA, Lidocaine
Drug
Lead sponsor
CAMC Health System
Other
Eligibility
3 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Oct 7, 2026, 3:26 AM EDT
Not listed Phase 1Phase 2 Interventional

Treatment of Chronic Migraine Headaches.

NCT03220113
View directory record Official record
Conditions
Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura, Migraine Disorders
Interventions
Dexamethasone, Lidocaine, Thiamine cohort
Combination Product
Lead sponsor
Corona Doctors Medical Clinics, Inc.
Other
Eligibility
10 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Corona, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

EMLA Cream as Analgesic for Outpatient Gynecological Procedures

NCT05970354
View directory record Official record
Conditions
Pain
Interventions
EMLA Cream, VersaPro Cream Base for Compounding
Drug
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face

NCT04523961
View directory record Official record
Conditions
Anesthesia, Local, Photodamaged Skin, Topical and Infiltration Anesthetic Toxicity
Interventions
2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion, 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)

NCT00444626
View directory record Official record
Conditions
Facial Wrinkles at the Nasolabial Folds
Interventions
Dermal Gel Extra (DGE), Restylane, EMLA Cream
Device · Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • La Jolla, California • Miami Beach, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2015 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 2 Interventional

Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN)

NCT00916942
View directory record Official record
Conditions
Postherpetic Neuralgia
Interventions
capsaicin 8%, Lidocaine (2.5%)/Prilocaine (2.5%) Cream
Drug
Lead sponsor
NeurogesX
Industry
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
6
States / cities
Naples, Florida • St. Petersburg, Florida • Marietta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2009 · Synced Oct 7, 2026, 3:26 AM EDT
Recruiting Not applicable Interventional

Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion

NCT06891794
View directory record Official record
Conditions
IUD
Interventions
Menstrual disc with EMLA cream, Cervical cap with EMLA cream
Combination Product
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser

NCT02427724
View directory record Official record
Conditions
Lentigo
Interventions
lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, placebo vehicle, Q-switched 532nm Laser
Drug · Device
Lead sponsor
Northwestern University
Other
Eligibility
25 Years to 65 Years · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Phase 2 Interventional

PSD502 in Subjects With Premature Ejaculation

NCT03578783
View directory record Official record
Conditions
Premature Ejaculation
Interventions
Placebo, PSD502
Drug
Lead sponsor
Plethora Solutions Ltd
Industry
Eligibility
18 Years and older · Male only
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
21
States / cities
Birmingham, Alabama • Mobile, Alabama • Sherman Oaks, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 7, 2026, 3:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Goggle Utilization for Venipuncture Distraction

NCT04479735
View directory record Official record
Conditions
Pain, Procedural
Interventions
Virtual Reality Goggles
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
5 Years to 21 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 7, 2026, 3:26 AM EDT
Terminated Not applicable Interventional

Local Anesthesia Before Bulkamid Injection

NCT06043063
View directory record Official record
Conditions
Stress Urinary Incontinence, Intrinsic Sphincter Deficiency
Interventions
Topical lidocaine, EMLA cream, Periurethral block
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 7, 2026, 3:26 AM EDT