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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: 5% Fluoride Varnish Clear all
Active, not recruiting Not applicable Interventional

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

NCT07556367
View directory record Official record
Conditions
Head and Neck Cancer, Head and Neck Carcinoma, Head and Neck Neoplasms
Interventions
Surveys, Saliva Collection, Intra-oral photographs, Fluoride Varnish Treatment, Interview (Participant)
Other · Procedure · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy and Safety Evaluation of Anti-Caries Varnish

NCT04947527
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Test varnish, Placebo
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
10 Months to 20 Months
Enrollment
274 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
0
States / cities
Not listed
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of Treatments to Prevent Dental Caries

NCT03448107
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
3,345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study

NCT02424097
View directory record Official record
Conditions
Dental White Spots, Dental Caries
Interventions
CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
11 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2020 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Results available

Xylitol for Caries Prevention in Inner-City Children

NCT01901250
View directory record Official record
Conditions
Dental Caries
Interventions
Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education, Fluoride varnish, Dental sealant
Dietary Supplement · Behavioral · Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 6 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dental Office Prevention Strategies for Children

NCT02004990
View directory record Official record
Conditions
Dental Plaque
Interventions
Single cleansing procedure of 10% Povidone Iodine
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
6 Years to 13 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Sep 24, 2026, 9:34 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Early Caries Lesion Management Observational Study

NCT04933331
View directory record Official record
Conditions
Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions
Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
Drug · Device
Lead sponsor
CareQuest Institute for Oral Health
Other
Eligibility
4 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2023 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silver Diamine Fluoride Pilot Study (SDF)

NCT02591147
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride 38%, Group 2 (Placebo)
Device
Lead sponsor
Justine Kolker
Other
Eligibility
21 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Sep 24, 2026, 9:34 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sensory Adapted Dental Environments to Enhance Oral Care for Children With and Without Dental Fear and Anxiety

NCT06912854
View directory record Official record
Conditions
Dental Fear and Anxiety
Interventions
Sensory Adapted Dental Environment, Video-based Modeling
Other
Lead sponsor
University of Southern California
Other
Eligibility
6 Years to 12 Years
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

NCT03770286
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries Class II, Dental Caries
Interventions
5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
3 Years to 12 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fluoride Varnish for Treatment of White Spot Lesions

NCT01500187
View directory record Official record
Conditions
White Spot Lesions
Interventions
Vanish Varnish, Pediagel
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
12 Years to 16 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 24, 2026, 9:34 AM EDT
Terminated Not applicable Interventional Results available

Clinical Trial Proximal Caries Infiltration and Detection

NCT01796106
View directory record Official record
Conditions
Caries,Dental
Interventions
Resin infiltration, Fluoride varnish & Oral hygiene instruction
Device
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
6 Years to 13 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of School-based Caries Prevention

NCT03442309
View directory record Official record
Conditions
Dental Caries, Quality of Life
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
7,418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 24, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes

NCT01629290
View directory record Official record
Conditions
Dental Caries
Interventions
Enamel Pro, Duraphat, Vanish, Placebo
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 21, 2017 · Synced Sep 24, 2026, 9:34 AM EDT