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ClinicalTrials.gov public records Last synced Oct 1, 2026, 7:41 PM EDT

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Showing 25–48 of 166 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: 60% oxygen Clear all
Completed Phase 1 Interventional

Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)

NCT00760734
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
Interventions
Low pressure hyperbaric oxygen therapy
Drug
Lead sponsor
Paul G. Harch, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat

NCT02935894
View directory record Official record
Conditions
Stability & Variability of Lipid-derived Molecules in Sweat
Interventions
Ibuprofen, Physiological induction of sweating, Pilocarpine
Drug · Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
20 Years to 40 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 1, 2026, 7:41 PM EDT
Not listed Not applicable Interventional

Non-invasive Fluid Management

NCT02892799
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult
Interventions
NICOM-Guided Diuresis, Standard of Care
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Oct 1, 2026, 7:41 PM EDT
Recruiting Phase 2 Interventional

Long-Term Outcomes Following HBOT

NCT07732374
View directory record Official record
Conditions
Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
Interventions
Hyperbaric Oxygen Therapy (HBOT)
Drug
Lead sponsor
Summit Hyperbarics and Wellness
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Severe Diabetic Gastroparesis

NCT00612014
View directory record Official record
Conditions
Gastroparesis, Diabetes Mellitus
Interventions
5% dextrose in water, TZP-101
Drug
Lead sponsor
Tranzyme, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
6
States / cities
San Francisco, California • Anderson, Indiana • Kansas City, Kansas + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2012 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

American Heart Association- Stroke/Hypoxia Study

NCT04019522
View directory record Official record
Conditions
Stroke
Interventions
Acute Intermittent Hypoxia (AIH)
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation Effects on Weight Change and Metabolic Rate

NCT01933113
View directory record Official record
Conditions
Obesity
Interventions
Deep Brain Stimulation of the Lateral Hypothalamic Area
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional

Measuring and Treating Brain Oxygen Levels in Open Heart Surgery

NCT01539382
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Cerebral oxygenation intervention
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2015 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)

NCT01220713
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
19 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Portsmouth, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2013 · Synced Oct 1, 2026, 7:41 PM EDT
Completed No phase listed Observational

Patient Palatability and Preference of 3 Potassium Binders in Patients With Chronic Kidney Disease and Hyperkalaemia

NCT04566653
View directory record Official record
Conditions
Chronic Kidney Disease + Hyperkalaemia +/- Heart Failure
Interventions
Calcium Polystyrene Sulphonate 15g/60 mL water, Lokelma® 5 g/45mL water, Lokelma® 10 g/45 mL water, Veltassa® 8,4 g/80mL water, Sodium Polystyrene Sulphonate 15g/60 mL water
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 130 Years
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Temple Terrace, Florida • West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluation of Canakinumab in High-Risk Former-Smokers

NCT06038526
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions
Biospecimen Collection, Bronchoscopy, Canakinumab, Carbon Monoxide Measurement, Survey Administration
Procedure · Biological · Other
Lead sponsor
Peter Shields
Other
Eligibility
40 Years to 73 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 1, 2026, 7:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Hyperbaric Oxygen Therapy on Cognitive Function on Autistic Spectrum Disordered Children

NCT00631215
View directory record Official record
Conditions
Cognition
Interventions
Hyperbaric oxygen therapy
Procedure
Lead sponsor
Pediatric Partners of Ponte Vedra
Other
Eligibility
6 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Ponte Vedra Beach, Florida
Source: ClinicalTrials.gov public record
Updated Mar 7, 2008 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 1 Interventional

Arsenic Trioxide, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia

NCT00093483
View directory record Official record
Conditions
Leukemia
Interventions
filgrastim, arsenic trioxide, cytarabine, idarubicin
Biological · Drug
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 59 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2014 · Synced Oct 1, 2026, 7:41 PM EDT
Completed No phase listed Observational

Prediction of Extubation Readiness in Extreme Preterm Infants by the Automated Analysis of CardioRespiratory Behavior

NCT01909947
View directory record Official record
Conditions
Prediction of Extubation Readiness
Interventions
Cardiorespiratory signal acquisition
Other
Lead sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Other
Eligibility
Not listed
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Detroit, Michigan • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Oct 1, 2026, 7:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair

NCT03433599
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Repeated exposure to acute Intermittent Hypoxia (rAIH), Normal Room Air, Upper-limb Training by Research Staff, Lower-limb Training by Research Staff
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion

NCT04181606
View directory record Official record
Conditions
Aging
Interventions
Esmolol infusion, Saline infusion, Pre exercise baseline, Isometric handgrip exercise, Semi-recumbent cycling
Drug · Other
Lead sponsor
David N. Proctor, PhD
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Oct 1, 2026, 7:41 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Electrical Stimulation of Human Myocytes in Microgravity

NCT03665051
View directory record Official record
Conditions
Sarcopenia
Interventions
Muscle Tissue Biopsy, Maximal Oxygen Consumption (V02max)
Procedure · Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
20 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketogenic Diet for Reduction of CNS Oxygen Toxicity in Working Divers

NCT03433261
View directory record Official record
Conditions
CNS Oxygen Toxicity, Ketogenic Diet
Interventions
Ketogenic Diet
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 14, 2021 · Synced Oct 1, 2026, 7:41 PM EDT
Recruiting No phase listed Observational

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

NCT06897670
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
Interventions
Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Timeline
2025 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 4 Interventional Results available

Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury

NCT05058677
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
aerosolized 2% lidocaine (20mg/ml), instilled 0.9% sodium chloride (NS), instilled 2% lidocaine solution, Endotracheal Suctioning (ETS)
Drug · Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Up to 16 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 1, 2026, 7:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI

NCT04460495
View directory record Official record
Conditions
Malignant Brain Neoplasm
Interventions
Arterial Spin Labeling Magnetic Resonance Imaging, pH-Weighted amine CEST, Oxygen-weighted SAGE-EPI
Procedure
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
Not listed
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Phase 1Phase 2 Interventional

Phase 1/2 Study of ThermoDox With Approved Hyperthermia in Treatment of Breast Cancer Recurrence at the Chest Wall

NCT00826085
View directory record Official record
Conditions
Breast Cancer
Interventions
ThermoDox in combination with Microwave Hyperthermia (heat)
Drug
Lead sponsor
Imunon
Industry
Eligibility
18 Years and older · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
San Francisco, California • Newnan, Georgia • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Oct 1, 2026, 7:41 PM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

NCT04534959
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
8
States / cities
Birmingham, Alabama • Denver, Colorado • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 1, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)

NCT02603835
View directory record Official record
Conditions
Anterior Wall Acute Myocardial Infarction
Interventions
SSO2 Therapy
Device
Lead sponsor
TherOx
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
15
States / cities
Huntsville, Alabama • La Jolla, California • Danbury, Connecticut + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 1, 2026, 7:41 PM EDT