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ClinicalTrials.gov public records Last synced Sep 30, 2026, 7:42 AM EDT

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Showing 25–48 of 57 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: 800 mg ibuprofen Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Scheduled or As Needed Pain Regimen?

NCT06495632
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Motrin and narcotic
Drug
Lead sponsor
Cape Fear Valley Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Fayetteville, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 30, 2026, 7:42 AM EDT
Active, not recruiting Phase 3 Interventional

RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee

NCT05318521
View directory record Official record
Conditions
Degenerative Arthritis
Interventions
Placebo, Ibuprofen modified release tablet 800 mg
Drug
Lead sponsor
Overseas Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
7
States / cities
Cerritos, California • Garden Grove, California • Santa Ana, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 30, 2026, 7:42 AM EDT
Recruiting No phase listed Observational

CHronic Nonbacterial Osteomyelitis International Registry

NCT04725422
View directory record Official record
Conditions
Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis
Interventions
Methotrexate, Sulfasalazine, Leflunomide, Pamidronate, Zoledronic acid, Etanercept, Adalimumab, Certolizumab, Infliximab, Golimumab, NSAID
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 21 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2050
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 3 Interventional Results available

Trial of Caldolor for Treatment of Pain in Post-Operative Adult Patients

NCT00225732
View directory record Official record
Conditions
Pain
Interventions
Normal saline as placebo comparator, Intravenous ibuprofen
Other · Drug
Lead sponsor
Cumberland Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
12
States / cities
Birmingham, Alabama • Mobile, Alabama • Montgomery, Alabama + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2016 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 2 Interventional Results available

Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)

NCT03173456
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
oxycodone/APAP, hydrocodone/APAP, codeine/APAP, 400 ibuprofen/APAP, 800 ibuprofen/APAP
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years to 64 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole

NCT00640809
View directory record Official record
Conditions
Bowel Diseases, Inflammatory
Interventions
Celecoxib, Placebo, Ibuprofen plus Omeprazole
Drug · Other
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
408 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2004
U.S. locations
12
States / cities
Scottsdale, Arizona • La Jolla, California • Los Angeles, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 30, 2026, 7:42 AM EDT
Not yet recruiting Phase 4 Interventional

RCT: Suzetrigine vs Norco for Post-op Pain

NCT07195669
View directory record Official record
Conditions
Pain Control
Interventions
Suzetrigine (SUZ), Norco
Drug
Lead sponsor
Jacob Lensing
Other
Eligibility
18 Years to 45 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 30, 2026, 7:42 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction

NCT02133326
View directory record Official record
Conditions
Impacted Wisdom Teeth
Interventions
Caldolor, Ofirmev
Drug
Lead sponsor
Tufts University School of Dental Medicine
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 20, 2017 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional

Caldolor Versus Caldolor Plus OFIRMEV in Total Knee or Hip Arthroplasty Surgeries

NCT01773005
View directory record Official record
Conditions
Pain
Interventions
Ofirmev, Caldolor
Drug
Lead sponsor
Anita Gupta
Other
Eligibility
18 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Action of Acetaminophen

NCT00646906
View directory record Official record
Conditions
Myocardial Infarction, Arthritis
Interventions
Aspirin First, Aspirin Last, Acetaminophen 1000 mg/d, Acetaminophen 4000 mg/d, Ibuprofen 800 mg/d
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional

Premedication to Reduce Discomfort With Screening Mammography

NCT00382083
View directory record Official record
Conditions
Breast Pain
Interventions
1000 mg acetaminophen, 800 mg ibuprofen, 1 oz 4% lidocaine gel
Drug
Lead sponsor
Mountain States Tumor and Medical Research Institute
Other
Eligibility
30 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Sep 28, 2006 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intramuscular Ketorolac Versus Oral Ibuprofen for Pain Relief in First Trimester Suction Curettage

NCT01595282
View directory record Official record
Conditions
Pain
Interventions
Ketorolac, Ibuprofen
Drug
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2014 · Synced Sep 30, 2026, 7:42 AM EDT
Not listed Phase 3 Interventional

Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics

NCT01297829
View directory record Official record
Conditions
Postoperative Pain
Interventions
Intravenous Ibuprofen, IV Placebo
Drug · Other
Lead sponsor
St. Barnabas Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Livingston, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 16, 2014 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Modernization of in vivo-in Vitro Oral Bioperformance Prediction and Assessment

NCT02806869
View directory record Official record
Conditions
Human Gastrointestinal Physiology Data
Interventions
Single dose of ibuprofen (800 mg tablet), Pulmocare, two 8.0 oz (236.6 mL) cans
Drug · Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2017 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 1 Interventional

A Study To Explore The Effect On Inflammatory Markers After Nasal Allergen Challenge In Subjects With Seasonal Allergic Rhinitis And The Effect Of A Single Dose Of Ibuprofen Or Fluticasone Propionate On The Allergen Response.

NCT01064726
View directory record Official record
Conditions
Allergic Rhinitis
Interventions
Ibuprofen, Fluticasone propionate, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
19 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 2, 2010 · Synced Sep 30, 2026, 7:42 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Ibuprofen Versus Ketorolac for Pain Relief During Hysterosalpingogram

NCT05190341
View directory record Official record
Conditions
Infertility, Female
Interventions
Ibuprofen 800 mg oral, Ketorolac 30mg oral
Drug
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 45 Years · Female only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Dec 24, 2024 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Oral Midazolam in First-trimester Surgical Abortions

NCT01830881
View directory record Official record
Conditions
Pain, Anxiety, Nausea
Interventions
Midazolam, Ibuprofen, Placebo-Cherry syrup, Lidocaine
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 30, 2026, 7:42 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study

NCT06496854
View directory record Official record
Conditions
Pain, IUD
Interventions
Lorazepam 1 mg, Ibuprofen 800 mg
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 30, 2026, 7:42 AM EDT
Withdrawn Phase 2 Interventional

Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury

NCT02443142
View directory record Official record
Conditions
Brain Concussion
Interventions
Ibuprofen, Acetaminophen
Drug
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Sep 30, 2026, 7:42 AM EDT
Not listed Phase 4 Interventional

A Pilot Study Comparing the Analgesic Efficacy of IV Ibuprofen and IV Ketorolac

NCT01514175
View directory record Official record
Conditions
Chronic Pelvic Pain
Interventions
IV Ibuprofen, IV Ketorolac
Drug
Lead sponsor
Culpeper Surgery Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Culpeper, Virginia
Source: ClinicalTrials.gov public record
Updated May 16, 2012 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Not applicable Interventional

Comparative Sedation Study of the MyoSure Hysteroscopic Tissue Removal System

NCT00979342
View directory record Official record
Conditions
Uterine Fibroids, Polyps
Interventions
Hysteroscopic Morcellator
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Phoenix, Arizona • Boca Raton, Florida • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2010 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional Results available

Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

NCT03859024
View directory record Official record
Conditions
Pain, Postoperative, Urethral Stricture
Interventions
Oxycodone, Acetaminophen, Gabapentin, celebrex, Bupivacaine, Ibuprofen 800 mg, Dexamethasone
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Male only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 4 Interventional Results available

A Pilot Study to Determine the Efficacy of Intravenous Ibuprofen for Pain Control Following Arthroscopic Knee Surgery

NCT01650519
View directory record Official record
Conditions
Arthroscopic Knee Surgery
Interventions
IV ibuprofen, IV ketorolac
Drug
Lead sponsor
Cumberland Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 23, 2016 · Synced Sep 30, 2026, 7:42 AM EDT
Completed Phase 1 Interventional

Pain Medications Following Thyroidectomy and Parathyroidectomy

NCT03640247
View directory record Official record
Conditions
Thyroid Disease, Parathyroid Diseases
Interventions
Non-narcotic group regimen, Narcotic group regimen
Drug
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Sep 30, 2026, 7:42 AM EDT