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Conditions: Bacterial Infections, Bacterial Infections and Mycoses, Infections, Vaginitis, Vaginal Diseases, Genital Diseases, Female, Female Urogenital Diseases, Urogenital Disease, Candidiasis, Mycoses, Vulvovaginitis, Vulvar Diseases, Vaginosis, Bacterial
Interventions: Nanopath Vaginitis Assay, BD Max™ Vaginal Panel, Cepheid Xpert® Xpress MVP, Hologic Aptima® BV Assay, Yeast Culture; Diagnostic Test
Lead sponsor: Nanopath, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: North Miami, Florida • New Orleans, Louisiana

Conditions: Squamous Cell Carcinoma of the Head and Neck, Carcinoma, Squamous Cell, Neoplasms, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Head and Neck Cancer
Interventions: Proxinium; Drug
Lead sponsor: Sesen Bio, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 17
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 14 more

Conditions: Adolescents With Type 2 Diabetes
Interventions: Comprehensive intervention (disease management program), Usual Care; Behavioral
Lead sponsor: Vanderbilt University; Other
Eligibility: 12 Years to 19 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Neonatal Abstinence Syndrome
Interventions: Clonidine HCL; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: Up to 14 Days
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Rotator Cuff Tear Arthropathy
Interventions: Not listed
Lead sponsor: University of Utah; Other
Eligibility: 50 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Type 1 Diabetes Mellitis
Interventions: Hybrid Closed Loop (HCL) x 2 weeks, AIDANET x 2 weeks, AIDANET AI x 4 weeks; Device
Lead sponsor: Sue Brown; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Sedentary Lifestyle, Cigarette Smoking
Interventions: PA+ Smoking Cessation (LMPA), Standard Care Smoking Counseling (SCC); Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 59 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Population at Risk
Interventions: Should I Screen website, Should I Screen print booklet; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 298 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Hypertension, Dyslipidemia, Diabetes Mellitus, Obesity, Cardiovascular Disease
Interventions: Experimental - 12 Week P3-EX Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants, Active Control - 12 Week ACSM-PAVS Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants; Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years to 64 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 3
States / cities: Farmington, Connecticut • Hartford, Connecticut • Storrs, Connecticut

Conditions: PTSD, Sleep Disorders
Interventions: prazosin, placebo; Drug · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 304 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 15
States / cities: Loma Linda, California • Long Beach, California • Palo Alto, California + 12 more

Conditions: Sickle Cell Disease
Interventions: Hydroxyurea; Drug
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 15 Years to 99 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Hyperglycemia, Diabetes
Interventions: glucose and insulin infusions; Device
Lead sponsor: Admetsys Corporation; Industry
Eligibility: 21 Years to 85 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2026
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Infants in Neonatal Intensive Care Units
Interventions: Education Plus (E+), Clinical Decision Support, Prescriber Audit and Feedback; Other
Lead sponsor: Columbia University; Other
Eligibility: Not listed
Enrollment: 6,184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 4
States / cities: Wilmington, Delaware • New York, New York • Philadelphia, Pennsylvania

Conditions: Obesity
Interventions: Multi-Modal Education (MME), Traditional Education (TE); Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 3,199 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 8
States / cities: Birmingham, Alabama • Washington D.C., District of Columbia • Iowa City, Iowa + 5 more

Conditions: Liver Tumor
Interventions: RFA controlled using echo decorrelation imaging, RFA controlled using standard manufacturer-specified algorithms; Procedure
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Liver Transplant, Liver Transplantation
Interventions: Immunosuppression withdrawal; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 7
States / cities: San Francisco, California • Chicago, Illinois • Boston, Massachusetts + 4 more

Conditions: COPD
Interventions: Every Step Counts; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years and older
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypercholesterolemia, ASCVD
Interventions: Referral to Pharmacist-Driven Medication Management Program, Best-Practice Alert; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 95 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Type 1 Diabetes
Interventions: Tandem t:slim X2 with Control-IQ Technology Pro, Standard Care (SC), Tandem t:slim X2 with Control-IQ Technology V1.5; Device
Lead sponsor: Marc Breton; Other
Eligibility: 24 Months to 71 Months
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Stanford, California • Aurora, Colorado • Charlottesville, Virginia

Conditions: Triple-Negative Breast Cancer (TNBC)
Interventions: BreakVax, Ipilimumab 2.5 mg, Pembrolizumab, Standard-of-care chemotherapy, Losartan and aspirin; Drug
Lead sponsor: BreakBio Corp; Industry
Eligibility: 18 Years to 72 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Diabetes Mellitus
Interventions: The Omnipod 5/Horizon HCL system; Device
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Stanford, California • Atlanta, Georgia • Charlottesville, Virginia

Conditions: Breast Cancer, Breast Carcinoma, Cancer of the Breast, Malignant Neoplasm of Breast
Interventions: Expression Networks for highLIGHting Tumor vulnerabilities (ENLIGHT), TruSight(R) Oncology 500, TruSeq Matched Tumor Normal Whole Exome Sequencing Assay; Device
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: TBI (Traumatic Brain Injury), Concussion, Brain, MTBI - Mild Traumatic Brain Injury, Closed Head Injury
Interventions: EEG Recording, Neurocognitive Tests, Clinician Evaluation, 22-item CSI; Device · Other
Lead sponsor: BrainScope Company, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 660 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 7
States / cities: Detroit, Michigan • Royal Oak, Michigan • Troy, Michigan + 2 more

Conditions: Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions: Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI); Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Cincinnati, Ohio • Columbus, Ohio

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Large Algorithm Setting and Validation Study

Study of Proxinium for Treating Patients With Squamous Cell Head and Neck Cancer

Situational Problem Solving in Adolescents With Type 2 Diabetes: Enhancing a Randomized Controlled Trial (RCT)

Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome

The Effects of Platelet Rich Plasma on the Integrity of Rotator Cuff Repair

Effectiveness of Artificial-Intelligence (AI) Bolus Priming Added to an Existing Fully Automated Control Algorithm (AIDANET)

Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers

Educating QUitline Callers About Lung Cancer Screening

A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD

Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease

Insulin Balanced Infusion System

Improving Antimicrobial Prescribing Practices in the Neonatal ICU

Weight Management Counseling in Medical Schools

Treat-and-resect Study of Echo Decorrelation Imaging-controlled Radiofrequency Ablation in Liver Tumors

Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation

COPD Access to Pulmonary Rehabilitation Intervention

Improving Lipid Optimization Quality and Treatment Options in ASCVD

The Pediatric Artificial Pancreas (PEDAP) Trial of Control-IQ Technology in Young Children in Type 1 Diabetes

Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy

Automated Insulin Delivery for INpatients With DysGlycemia (AIDING) Feasibility

A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

Follow-up of MTBI Patients Discharged from the ED Using Standard Clinical Triage Including BrainScope One

The STop UNhealthy Substance Use Now Trial