- Conditions
- Alpha 1-Antitrypsin Deficiency, Emphysema, COPD
- Interventions
- Placebo Oral Tablet, Alvelestat oral tablet - dose 1, Alvelestat oral tablet - dose 2
- Drug
- Lead sponsor
- Mereo BioPharma
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 99 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2022
- U.S. locations
- 4
- States / cities
- Birmingham, Alabama • Los Angeles, California • Sacramento, California + 1 more
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- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- AZD9668, AZD9668 Placebo
- Drug
- Lead sponsor
- AstraZeneca
- Industry
- Eligibility
- 40 Years to 80 Years
- Enrollment
- 838 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2010
- U.S. locations
- 9
- States / cities
- Fullerton, California • Valparaiso, Indiana • Council Bluffs, Iowa + 6 more
- Conditions
- Type 2 Diabetes Mellitus, Insulin Resistance
- Interventions
- Metformin, saxagliptin, AZD9668, placebo
- Drug
- Lead sponsor
- Nick Giannoukakis, PhD
- Other
- Eligibility
- 21 Years to 75 Years
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania