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Showing 1–24 of 285 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Acceptance-based therapy Clear all
Active, not recruiting Phase 1Phase 2 Interventional

Study of d-MAPPS™ Ophthalmic Solution, Safety, Tolerability, and Efficacy in the Treatment of Chronic Ocular Graft-Versus-Host Disease (oGVHD)

NCT06852768
View directory record Official record
Conditions
oGHVD
Interventions
d-MAPPS, Placebo, PI and Patient Masked
Biological · Other
Lead sponsor
Regenerative Ocular Immunobiologics LLC
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
6
States / cities
Beverly Hills, California • Huntington Beach, California • Palm Harbor, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

Smartphone Training for Attention Regulation for IBS

NCT05083091
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Mindfulness and Attention Training, Mindfulness training, Coping Condition
Behavioral
Lead sponsor
Carnegie Mellon University
Other
Eligibility
18 Years and older
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Sep 11, 2026, 2:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Mental Health Curriculum Study

NCT04338256
View directory record Official record
Conditions
Mental Health Issue
Interventions
Wellness and Resilience for College and Beyond (Undergraduate College Course)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 24 Years
Enrollment
295 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
5
States / cities
Greensburg, Pennsylvania • Pittsburgh, Pennsylvania • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 18, 2021 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Treatment for Weight Loss

NCT00746265
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Behavioral weight loss intervention
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2013 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

A Novel Intervention for Patients With Cancer

NCT05643027
View directory record Official record
Conditions
Substance Use, Cancer, Psychological
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Recruiting Not applicable Interventional

A Randomized Controlled Trial Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED")

NCT07632248
View directory record Official record
Conditions
Eating Disorders, Body Image
Interventions
FlexED, Educational Control
Behavioral
Lead sponsor
Duke University
Other
Eligibility
15 Years to 25 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Active, not recruiting No phase listed Observational

Stroke Prevention in Young Adults With Sickle Cell Anemia

NCT04808778
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Stroke, Ischemic, Silent Stroke, Silent Cerebral Infarct, Stroke
Interventions
Hydroxyurea therapy per standard care
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
16 Years to 26 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

NCT05361811
View directory record Official record
Conditions
Neurofibromatosis 1, Noonan Syndrome, Legius Syndrome, Cardiofaciocutaneous Syndrome, Costello Syndrome
Interventions
Waitlist, ACT Intervention
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Early Phase Clinical Trial to Test the Feasibility of an ACT-based Physical Activity Promotion Program for Adults With Depressive Symptoms

NCT05407935
View directory record Official record
Conditions
Physical Inactivity
Interventions
ACTivity, Relaxercise
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Withdrawn Not applicable Interventional

Videoconferencing Acceptance and Commitment Therapy With a Web App Use for Family Caregivers of People With Dementia

NCT05518968
View directory record Official record
Conditions
Depression
Interventions
Acceptance and commitment therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 11, 2026, 2:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Promoting the Well Being of Caregivers Via Telehealth

NCT05999448
View directory record Official record
Conditions
Caregivers, Parents
Interventions
Acceptance and Commitment Therapy (ACT), Culturally Informed Cognitive Behavioral Therapy (CICBT), Individual, Culturally Informed Cognitive Behavioral Therapy (CICBT), Group, Dialectical Behavioral Therapy (DBT), Durand Sleep Intervention, RUBI Intervention, Naturalistic Communication Intervention (NCI), Self-Guided Resources, Participation Enhancement Intervention (PEI)
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 70 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 11, 2026, 2:05 PM EDT
Recruiting Not applicable Interventional

Training in Evidence-based Treatments in Psycho-Oncology

NCT05674357
View directory record Official record
Conditions
Distress, Emotional, Depression, Anxiety, Fatigue, Pain, Insomnia
Interventions
Individualized Evidence-Based Therapy in Cancer (Patients and Caregivers), Training in Individualized Evidence-Based Therapy in Cancer (Therapists)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Chronic Pain in Integrated Primary Care

NCT04978961
View directory record Official record
Conditions
Chronic Pain
Interventions
Focused Acceptance & Commitment Therapy (FACT), Enhanced Treatment as Usual (ETAU)
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 99 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of the Predictors and Moderators of Health Behavior Change

NCT03139656
View directory record Official record
Conditions
Health Behaviors
Interventions
Values Clarification, Planning, Combined
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

Smoking Cessation Intervention for Diabetic Patients

NCT01501877
View directory record Official record
Conditions
Smoking, Type 2 Diabetes
Interventions
Acceptance and Commitment Therapy, Standard smoking cessation intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Results available

FlexED: A Digital, Gamified Early Intervention for Eating Disorders

NCT05609409
View directory record Official record
Conditions
Eating Disorders, Body Image
Interventions
FlexED
Behavioral
Lead sponsor
Duke University
Other
Eligibility
15 Years to 25 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Phase 3 Interventional Results available

A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}

NCT02358343
View directory record Official record
Conditions
Depression, End Stage Renal Disease
Interventions
Engagement Interview, Cognitive Behavioral Therapy, Antidepressant Drug Therapy
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
21 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
Albuquerque, New Mexico • Dallas, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 11, 2026, 2:05 PM EDT
Active, not recruiting Not applicable Interventional

Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain

NCT06044649
View directory record Official record
Conditions
Chronic Pain, Neck Pain, Back Pain
Interventions
Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Emotional Awareness and Expression Therapy, Treatment as Usual
Behavioral · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Recruiting Not applicable Interventional

Evaluating Additive Effects of Including Canines in Regulating Together

NCT05803343
View directory record Official record
Conditions
Autism Spectrum Disorder, Emotion Regulation
Interventions
Regulating Together-Canine, Regulating Together-Standard
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 15 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The REACH Study: A Novel Values-Based Intervention to Increase Endocrine Therapy Adherence Among Breast Cancer Survivors

NCT03980093
View directory record Official record
Conditions
Breast Cancer
Interventions
Education, Values
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Greenwood Village, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Sep 11, 2026, 2:05 PM EDT
Recruiting Phase 2 Interventional

ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes

NCT04933851
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
ACT1VATE, DSME/S
Behavioral
Lead sponsor
Scripps Whittier Diabetes Institute
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Family Caregivers of People With Dementia

NCT04458870
View directory record Official record
Conditions
Psychological Distress
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Results available

Developing an Online Therapeutic Intervention for Chronic Pain in Veterans

NCT03655132
View directory record Official record
Conditions
Chronic Pain
Interventions
Veteran Acceptance and Commitment Therapy for Chronic Pain
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional

iOmit: Reducing Intentional Insulin Misuse in Type 1 Diabetes

NCT02980627
View directory record Official record
Conditions
Type 1 Diabetes Mellitus, Eating Disorders
Interventions
Therapy with Mobile App Enhancement
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 11, 2026, 2:05 PM EDT