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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:16 PM EST

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Showing 25–48 of 149 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Acetaminophen Plus Ibuprofen Clear all

Conditions: Post-Dural Puncture Headache
Interventions: Lidocaine HCl Gel 2%, placebo gel; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 50 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Glycogen Storage Disease Type III
Interventions: UX053, Placebo, Antipyretic, H2 Blocker, H1 Blocker; Biological · Other · Drug
Lead sponsor: Ultragenyx Pharmaceutical Inc; Industry
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 4
States / cities: Orange, California • Atlanta, Georgia • Philadelphia, Pennsylvania + 1 more

Conditions: Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI), Postoperative Pain
Interventions: Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Pain
Interventions: Ultrasound guided nerve block; Procedure
Lead sponsor: Antonios Likourezos; Other
Eligibility: 18 Years to 120 Years
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Pain
Interventions: Pharmacogenomic Testing, Ibuprofen, hydroxycontin/acetominophen, acetominophen, Oxycontin/acetominophen; Other · Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years to 35 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Tonsillectomy
Interventions: Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade; Drug · Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 2 Years to 12 Years
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
Interventions: pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID; Other · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 5 Days to 14 Days
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 13
States / cities: San Diego, California • San Francisco, California • San Jose, California + 9 more

Conditions: Pain, Orofacial
Interventions: Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg, Placebo oral tablet; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 12 Years to 80 Years
Enrollment: 375 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Hypertension, Pregnancy-Induced, Pre-eclampsia
Interventions: Ibuprofen, Acetaminophen; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Fever
Interventions: Ibuprofen 250 mg / Acetaminophen 500 mg, Ibuprofen 250 mg, Acetaminophen 500 mg, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 55 Years · Male only
Enrollment: 290 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Supracondylar Humerus Fracture
Interventions: Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen; Drug
Lead sponsor: Le Bonheur Children's Hospital; Other
Eligibility: 4 Years to 13 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Dental Pain
Interventions: Full Dose Strength, Quarter dose strength, Half dose strength, Acetaminophen standard dose, Ibuprofen low dose, Ibuprofen high dose, Placebo; Drug
Lead sponsor: AFT Pharmaceuticals, Ltd.; Industry
Eligibility: 16 Years to 40 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Fever
Interventions: Intravenous Ibuprofen, Acetaminophen (Standard of Care); Drug
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Patent Ductus Arteriosus After Premature Birth
Interventions: Ibuprofen; Drug
Lead sponsor: IWK Health Centre; Other
Eligibility: Up to 72 Hours
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 3
States / cities: Orange, California • San Diego, California • Oklahoma City, Oklahoma

Conditions: Pediatric Disorder
Interventions: Acetaminophen, Ibuprofen; Drug
Lead sponsor: Baylor Research Institute; Other
Eligibility: 3 Years to 18 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Temple, Texas

Conditions: Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
Interventions: Ivermectin; Drug
Lead sponsor: Patrick Robinson; Other
Eligibility: 12 Years to 110 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: San Antonio, Florida

Conditions: Rib Fractures, Rib Fracture Multiple
Interventions: Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen; Drug
Lead sponsor: Andrew A Herring; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Oakland, California

Conditions: Tendinopathy
Interventions: Amino Acids; Dietary Supplement
Lead sponsor: Purdue University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: West Lafayette, Indiana

Conditions: Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder
Interventions: Educational Intervention, Gabapentin, Pain Therapy, Quality-of-Life Assessment, Questionnaire Administration, Oxycodone/Acetaminophen, Hydrocodone/Acetaminophen, Fentanyl, Ibuprofen, Magic Mouthwash; Other · Drug
Lead sponsor: Vanderbilt-Ingram Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Second Trimester Abortion
Interventions: Transcutaneous Electrical Nerve Stimulation (TENS) unit, Placebo; Device
Lead sponsor: Queen's Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Other Chronic Postoperative Pain
Interventions: Duramorph 150, Acetaminophen, Duramorph 300; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
Interventions: Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP; Combination Product
Lead sponsor: QC Kinetix LLC; Industry
Eligibility: 50 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Tonsillectomy
Interventions: Honey, Standard of Care; Dietary Supplement · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 5 Years to 17 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pre-Eclampsia, HELLP Syndrome, Eclampsia
Interventions: Acetaminophen, Ibuprofen; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Search by objective public record fields.

RCT of SPG Blocks for Post-dural Headache

Safety, Tolerability, and Pharmacokinetics of UX053 in Patients With Glycogen Storage Disease Type III (GSD III)

Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery

Prevention of Post Herpetic Neuralgia by Ultrasound Guided Single Nerve Block in the ED

Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes

Muscle Relaxation for Pediatric Adenotonsillectomy

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management

The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy

A Study of Ibuprofen 250 mg / Acetaminophen 500 mg Comparing The Antipyretic Effects in Healthy Male Volunteers

NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures

Maxi-Analgesic Phase 2 Study to Compare the Analgesic Effects in Different Dosing Groups to Treat Teeth Extraction Pain

Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage

Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT

Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen?

Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19

US-guided SAPB for Rib Fractures in the ED

Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise

Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy

TENS Unit To Decrease Pain After Laminaria Insertion

High Pain Intervention in Cesarean Sections

Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis

Here's the Buzz: Evaluating Pediatric Post Op Pain and Nausea Following Tonsillectomy Surgery

Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features