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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:27 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 149 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Acetaminophen Plus Ibuprofen Clear all

Conditions: Postoperative Pain
Interventions: HTX-011, ZYNRELEF kit components for administration, MMA regimen; Drug · Device
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 4
States / cities: Sheffield, Alabama • San Diego, California • Durham, North Carolina + 1 more

Conditions: Pain, Postoperative
Interventions: Dexamethasone, Analgesics; Drug
Lead sponsor: Duke University; Other
Eligibility: 4 Years to 17 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Shoulder Pain
Interventions: ibuprofen 600 mg, Oxycodone/acetaminophen (Percocet) 5 mg/325; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use, Spinal Diseases, Surgery--Complications, Surgery, Postoperative Pain
Interventions: Opioid Analgesic, Opioid-Free Postoperative Pain Regimen; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pain
Interventions: Ofirmev, Caldolor; Drug
Lead sponsor: Anita Gupta; Other
Eligibility: 18 Years to 70 Years
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Anesthesia, Local, Prolapse, Prolapse; Female, Prolapse, Vaginal, Prolapse; Vagina, Posthysterectomy, Pain, Postoperative
Interventions: TAP block; Procedure
Lead sponsor: ProMedica Health System; Other
Eligibility: 18 Years and older · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Toledo, Ohio

Conditions: Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
Interventions: Ibuprofen and acetaminophen, Ibuprofen and placebo; Drug
Lead sponsor: University of South Alabama; Other
Eligibility: 5 Days to 21 Days
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Mobile, Alabama

Conditions: Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid, Central Nervous System Depressants, Narcotics
Interventions: 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Appendicitis, Pain, Postoperative
Interventions: Non-narcotic pain control; Drug
Lead sponsor: University of Utah; Other
Eligibility: Up to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use, Back Pain, Back Injuries, Chronic Pain, Chronic Low-back Pain, Pain, Chronic, Pain;Back Low;Chronic, Pain, Back
Interventions: Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain Management
Interventions: Ibuprofen, APAP; Drug
Lead sponsor: Antonios Likourezos; Other
Eligibility: 3 Years to 17 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Sleep, Pediatrics, Adenotonsillectomy
Interventions: Not listed
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 13 Years to 18 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Patent Ductus Arteriosus
Interventions: Acetaminophen; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 23 Weeks to 30 Weeks
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Albany, New York

Conditions: Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
Interventions: Bupivacaine, Morphine, Lidocaine; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Adenotonsillectomy, Analgesia, Surgery
Interventions: Dexamethasone, Ibuprofen, Acetaminophen, Placebo; Drug
Lead sponsor: David Chi, MD; Other
Eligibility: 3 Years to 17 Years
Enrollment: 222 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Sewickley, Pennsylvania

Conditions: Pain
Interventions: Ibuprofen/acetaminophen, Ibuprofen, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 16 Years to 40 Years
Enrollment: 394 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Cesarean Section Complications
Interventions: Ibuprofen, acetaminophen, oxycodone; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Supracondylar Humerus Fracture
Interventions: Ibuprofen, Hydrocodone/acetaminophen, Acetaminophen; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 3 Years to 12 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 3
States / cities: Houston, Texas

Conditions: Opioid Use, Pain, Postoperative
Interventions: Ibuprofen, Acetaminophen, Norco; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 170 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Herpangina, Gingivostomatitis, Hand, Foot and Mouth Disease
Interventions: Sucralfate, Placebo, Acetaminophen, Ibuprofen; Drug · Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 6 Months to 5 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Pain Management
Interventions: Naproxen, Acetaminophen (Standard of Care), ibuprofen; Drug
Lead sponsor: Zitelli & Brodland Skin Cancer Center; Other
Eligibility: Not listed
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Clairton, Pennsylvania

Conditions: Asthma, Wheezing
Interventions: Acetaminophen, Ibuprofen; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 12 Months to 59 Months
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 15
States / cities: Tucson, Arizona • Oakland, California • San Francisco, California + 10 more

Conditions: Adolescent Idiopathic Scoliosis (AIS)
Interventions: open-label placebo, Treatment as usual; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 10 Years to 18 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Low Back Pain
Interventions: Biomodulator, Usual Care (Medication + Exercise); Device · Other
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 62 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Search by objective public record fields.

PK and Safety After C-Section

Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients

Multimodal Analgesia With NSAID vs. Narcotics Alone After Shoulder Instability Surgery

Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery

Caldolor Versus Caldolor Plus OFIRMEV in Total Knee or Hip Arthroplasty Surgeries

Tap Block vs Conventional Pain Medication for Patients Undergoing Robotic Sacrocolpopexy

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

IBUPAP Study for Pain Management in Children

Postoperative Pain After Pediatric Adenotonsillectomy With Ketorolac or Ibuprofen

Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications

Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity

Evaluation of the Efficacy of Novel Ibuprofen Acetaminophen Combination Formulations in the Treatment of Post-surgical Dental Pain

Towards Enhanced Recovery After Cesarean

Post-operative Pain Management in Children With Supracondylar Humerus Fractures

Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section

Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial

Effect of Over-the-counter Analgesics on Postoperative Pain

Acetaminophen Versus Ibuprofen in Children With Asthma

Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis

A Pilot Study Examining the Efficacy of Biomodulator Treatment for Chronic Low Back Pain