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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:40 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 149 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Acetaminophen Plus Ibuprofen Clear all

Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet; Drug
Lead sponsor: University of Washington; Other
Eligibility: Not listed
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pain, BPH With Urinary Obstruction, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
Interventions: Ibuprofen 600 mg, Education; Drug · Behavioral
Lead sponsor: Benaroya Research Institute; Other
Eligibility: 18 Years and older · Male only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Shoulder Pain
Interventions: Tylenol and NSAIDS (Ibuprofen, diclofenac); Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Columbia, Maryland

Conditions: Musculoskeletal Pain
Interventions: Acetaminophen, Oxycodone; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 393 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
Interventions: Antiemetic anesthesia protocol; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 15 Years and older
Enrollment: 233 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Distal Radius Fracture
Interventions: Ibuprofen, Acetaminophen; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Tonsillectomy, Adenoidectomy
Interventions: Ibuprofen, Acetaminophen; Drug
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Eligibility: 2 Years to 18 Years
Enrollment: 741 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 5
States / cities: San Diego, California • Boston, Massachusetts • San Antonio, Texas + 2 more

Conditions: Pituitary Tumor, Pain
Interventions: IV Caldolor, IV Placebo; Drug
Lead sponsor: St. Joseph's Hospital and Medical Center, Phoenix; Other
Eligibility: 18 Years to 79 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Bone Fracture
Interventions: ketamine, fentanyl, ibuprofen or acetaminophen; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 4 Years to 17 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Pain
Interventions: Paracetamol and Caffeine, Ibuprofen, Placebo; Drug · Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 365 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: Low Back Pain
Interventions: Acetaminophen, Ibuprofen 600 mg, Educational intervention, Placebo oral capsule; Drug · Behavioral
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years to 69 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Interventions: Stepwise normothermia protocol, Ibuprofen, Acetominophen; Other · Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pain, Acute
Interventions: cannabidiol, placebo, acetaminophen 500mg and ibuprofen 200mg combo; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Pain, Thyroidectomy
Interventions: Acetaminophen and hydrocodone based pain control, Acetaminophen and ibuprofen based pain control; Other
Lead sponsor: Medstar Health Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Pain Management, Shared Decision Making
Interventions: Decision-Aid with 2-options, Decision aid with 3 options; Other
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 90 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
Interventions: Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol; Drug · Other
Lead sponsor: University of Nebraska; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Omaha, Nebraska • Cincinnati, Ohio

Conditions: Fever
Interventions: Prescription for weight-based dosing of antipyretic, Standard discharge instructions; Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 6 Months to 36 Months
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy, Mohs Surgery
Interventions: Suzetrigine, Acetaminophen Plus Ibuprofen; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 3
States / cities: Maple Grove, Minnesota • Minneapolis, Minnesota • Wyoming, Minnesota

Conditions: Sleep Apnea, Obstructive, Respiration Disorders
Interventions: supraglottoplasty with laser; Procedure
Lead sponsor: Indiana University; Other
Eligibility: 1 Year to 18 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2019
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Postoperative Pain, Opioid Use
Interventions: Conditioned open-label placebo (COLP), Surveys about pain, opioid use and depression symptoms; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
Interventions: No opioids at discharge; Behavioral
Lead sponsor: Albany Medical College; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Albany, New York

Conditions: Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
Interventions: Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs; Drug · Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Adolescent Idiopathic Scoliosis (AIS)
Interventions: Opioid-Free/Opioid-Avoidant, Opioid-Containing; Drug
Lead sponsor: OrthoCarolina Research Institute, Inc.; Other
Eligibility: 10 Years to 20 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: Comparison of medication administration for pain control; Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis

Optimizing Pain Control in Transurethral Resection of the Prostate

Post-Operative Pain Control Following Shoulder Surgery

Acetaminophen (APAP) +/- Oxycodone

Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture

Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy

Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors

IN Sub-Dissociative Ketamine vs IN Fentanyl

Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache

Ibuprofen With or Without Acetaminophen for Low Back Pain

Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever

Analgesic Effects of Cannabidiol for Simple Tooth Extractions in Dental Patients

Non-opioid Based Pain Control After Thyroidectomy

ACE Pilot 3: Decision Aid 2 Options vs 3 Options

Pain Management Following Sinus Surgery

Prescription Antipyretics to Decrease Unscheduled Return Visits In A Pediatric Emergency Department

Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery

Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty

Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer

No Opioids PrescrIptions On Discharge After Surgery

Postpartum NSAIDS and Maternal Hypertension

Prospective Opioid-Free AIS Fusion

Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery