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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:22 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 149 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Acetaminophen Plus Ibuprofen Clear all

Conditions: Pain
Interventions: Oxycodone/acetaminophen, Hydrocodone/acetaminophen, Codeine/acetaminophen, Ibuprofen/acetaminophen; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Ankle Fracture
Interventions: Ibuprofen, Acetaminophen/hydrocodone; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 60 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Gastrointestinal Mucosal Damage
Interventions: Ibuprofen, Paracetamol, Placebo; Drug · Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Dental Pain
Interventions: Maxigesic 325, Acetaminophen, Ibuprofen, Placebo; Drug
Lead sponsor: AFT Pharmaceuticals, Ltd.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 408 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Acute Pain, Surgery
Interventions: Prescription by surgical team, Recommendation by surgical team; Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Post Operative Pain, Acute
Interventions: Combogesic® tablets, Acetaminophen 500mg, Placebo; Drug
Lead sponsor: AFT Pharmaceuticals, Ltd.; Industry
Eligibility: 12 Years to 17 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Recurrent Acute Leukemia, Recurrent B Acute Lymphoblastic Leukemia, Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm, Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Recurrent Hairy Cell Leukemia, Recurrent Hematologic Malignancy, Recurrent Hodgkin Lymphoma, Recurrent T Acute Lymphoblastic Leukemia, Refractory Acute Leukemia, Refractory B Acute Lymphoblastic Leukemia, Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm, Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Refractory Hairy Cell Leukemia, Refractory Hematologic Malignancy, Refractory Hodgkin Lymphoma, Refractory T Acute Lymphoblastic Leukemia, Systemic Mastocytosis
Interventions: Acetaminophen, Dexamethasone, Diphenhydramine, Flotetuzumab, Ibuprofen, Ranitidine; Drug · Biological
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 12 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Duarte, California

Conditions: Acute Pancreatitis
Interventions: Ketorolac, Opioid; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Up to 21 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Postoperative Pain
Interventions: Preoperative Gabapentin/Postoperative Placebo, Preoperative Gabapentin/Postoperative Gabapentin; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Pain, Postoperative
Interventions: Gabapentin, hydrocodone, acetaminophen and ibuprofen; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 12 Years to 18 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Albany, New York

Conditions: Postoperative Pain, Patient Satisfaction, Analgesia
Interventions: Not listed
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Postoperative Pain
Interventions: Plain bupivacaine, Liposomal bupivacaine; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 80 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Opioid Use, Arthropathy of Knee, Pain, Postoperative
Interventions: RelieVRx headset, multi-modality pain management; Device · Drug
Lead sponsor: AppliedVR Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 3
States / cities: Danville, Pennsylvania • Wilkes-Barre, Pennsylvania

Conditions: Anorectal Disorder
Interventions: ERAS, Standard of care; Combination Product
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Adenotonsillectomy, Post-operative Analgesia, Opioid Use
Interventions: Oxycodone, Ibuprofen, Acetaminophen, Opioid disposal pouch, Opioid disposal education; Drug · Other
Lead sponsor: David Chi, MD; Other
Eligibility: 3 Years to 17 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Rotator Cuff Tear
Interventions: Rotator cuff repair, Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole, Hydrocodone/Acetaminophen; Procedure · Drug
Lead sponsor: University of Chicago; Other
Eligibility: 45 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use, Otolaryngologic Disease, Postoperative Pain, Pain
Interventions: OxyCODONE 5 Mg (milligram) Oral Tablet, Ibuprofen 600 Mg (milligram) Oral Tablet, Acetaminophen 650 MG (milligram) Oral Tablet; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 5
States / cities: Stanford, California • Evanston, Illinois • Rochester, Minnesota + 2 more

Conditions: Pain, Hernia
Interventions: Ibuprofen, Opioid Medication, Placebo, Ibuprofen + Opioid medication; Drug
Lead sponsor: Mike O'Callaghan Military Hospital; Federal
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Nellis Air Force Base, Nevada

Conditions: Post-operative Pain
Interventions: Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®, Panadeine® Extra, Placebo; Drug
Lead sponsor: Reckitt Benckiser LLC; Industry
Eligibility: 16 Years and older
Enrollment: 678 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Analgesics, Opioid, Acute Pain, Tooth Extraction, Adolescent, Acetaminophen, Ibuprofen
Interventions: Multicomponent intervention, Usual care; Behavioral · Other
Lead sponsor: Douglas Oyler; Other
Eligibility: 12 Years to 25 Years
Enrollment: 38,159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Hypertension, Pregnancy-Induced
Interventions: Acetaminophen, Ibuprofen; Drug
Lead sponsor: MemorialCare Health System; Other
Eligibility: 18 Years and older · Female only
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Long Beach, California

Conditions: Carpal Tunnel Syndrome, Dupuytren Contracture, Trigger Digit, Ganglion Cysts, De Quervain Disease
Interventions: Oxycodone Hcl 5Mg, Ibuprofen 400 mg, Acetaminophen 650 mg; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Skin Laxity
Interventions: Advil, Lortab, Ulthera System Treatment; Drug · Device
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Rockville, Maryland

Conditions: Pain
Interventions: Oxycodone/acetaminophen, Ibuprofen/acetaminophen; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 65 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Albany, New York

Search by objective public record fields.

Comparative Efficacy of 4 Oral Analgesics

NSAIDS Versus Opioids in Acute SER II Ankle Fractures

Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics

Maxigesic 325 Acute Dental Pain Study

Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain:

A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery

Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Effect of Perioperative Gabapentin on Postoperative Opioid Requirements

Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy

Post Operative Analgesia and Patient Satisfaction

TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery

Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy

The Effect of NSAIDs After a Rotator Cuff Repair Surgery.

Pain Control Following Sinus Surgery

Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy

Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study

Alternatives to Dental Opioid Prescribing After Tooth Extraction

Hypertension In Postpartum Preeclampsia Study

Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery

Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ Treatments

Randomized Trial of Two Analgesics in Elderly ED Patients