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Showing 1–24 of 127 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Active Neurostimulation Clear all
Completed Not applicable Interventional

Neurostimulation for Cognitive Enhancement in Alzheimer's Disease

NCT04404153
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS., tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver sham tDCS.
Device
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study

NCT07517172
View directory record Official record
Conditions
Temporomandibular Disorder
Interventions
Transcutaneous Auricular Neurostimulation, Sham Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Active, not recruiting Phase 1 Interventional

BHV-7000 Responsive Neurostimulation System (RNS) Study

NCT07125261
View directory record Official record
Conditions
Epilepsy, Seizures
Interventions
BHV-700
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Non-Invasive Neurostimulation For the Relief of Symptoms Associated With Migraine

NCT01532830
View directory record Official record
Conditions
Migraine
Interventions
n-VNS
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
3
States / cities
San Francisco, California • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Clinical Trial to Study a Non-invasive Neurostimulation Device on Urgency (Urinary) Incontinence Overactive Bladder (OAB)

NCT01125722
View directory record Official record
Conditions
Overactive Bladder
Interventions
Non-invasive neurostimulation device
Device
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Washington D.C., District of Columbia • Royal Oak, Michigan • Lawrenceville, New Jersey + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2012 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLS

NCT05196828
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
NTX100 Neuromodulation System
Device
Lead sponsor
Noctrix Health, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
7
States / cities
San Leandro, California • Colorado Springs, Colorado • Atlanta, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Does Improving Vagal Tone Increase Mitochondrial Bioenergetics

NCT03931330
View directory record Official record
Conditions
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Dyspepsia, Functional Abdominal Pain Syndrome
Interventions
Percutaneous neurostimulation
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
12 Years to 18 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 20, 2021 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional

tAN for PTSD and OUD in Buprenorphine Therapy

NCT06130501
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions
Sparrow Ascent tAN, Sparrow Ascent Active Sham
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cape Girardeau, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adaptive Recruitment Curve Analysis Using Bayesian Modeling

NCT07561372
View directory record Official record
Conditions
Modeling of Recruitment Curves
Interventions
Algorithm: Uniform Sampling, Algorithm: hbMEP-adaptive algorithm (version 1), Algorithm: hbMEP-adaptive algorithm (version 2), ML-PEST, MagPro X100 Transcranial Magnetic Stimulation, Digitimer DS8R Transcutaneous Electrical stimulation
Other · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Assessment of Safety and Efficacy of Nerivio for the Migraine Prevention

NCT04828707
View directory record Official record
Conditions
Migraine
Interventions
Nerivio active device, Nerivio sham device
Device
Lead sponsor
Theranica
Industry
Eligibility
18 Years to 75 Years
Enrollment
335 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
16
States / cities
Phoenix, Arizona • Carlsbad, California • Newport Beach, California + 13 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities

NCT06807684
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
transcranial magnetic stimulation
Device
Lead sponsor
Christiana Care Health Services
Other
Eligibility
13 Years to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator

NCT02526290
View directory record Official record
Conditions
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Interventions
Intranasal Lacrimal Neurostimulator (Oculeve)
Device
Lead sponsor
Oculeve, Inc.
Industry
Eligibility
22 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Phoenix, Arizona • Andover, Massachusetts • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

NCT04950894
View directory record Official record
Conditions
Obstructive Sleep Apnea, OSA, Apnea, Apnea, Obstructive, Apnea, Obstructive Sleep, Apnea+Hypopnea, Hypopnea, Sleep
Interventions
Hypoglossal Nerve Stimulation
Device
Lead sponsor
LivaNova
Industry
Eligibility
22 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
19
States / cities
Birmingham, Alabama • Tucson, Arizona • Roseville, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Terminated Not applicable Interventional

Use of tAN® in Alcohol Withdrawal Management

NCT06771037
View directory record Official record
Conditions
Alcohol Withdrawal
Interventions
Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
Erin Takemoto
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Wernersville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Modulation of Brain Rhythms in Stroke

NCT07121582
View directory record Official record
Conditions
Stroke
Interventions
Motor Brain Stimulation, Visual Brain Stimulation
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
45 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Patients With and Without Von Willebrand Disease

NCT06064851
View directory record Official record
Conditions
Von Willebrand Disease, Type 1, Heavy Menstrual Bleeding
Interventions
Volta System
Device
Lead sponsor
Five Liters, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

NCT06892340
View directory record Official record
Conditions
Motion Sickness
Interventions
Transcutaneous Auricular Neurostimulation device
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation

NCT02910713
View directory record Official record
Conditions
Dry Eye Syndromes
Interventions
Intranasal Tear Neurostimulator
Device
Lead sponsor
Allergan
Industry
Eligibility
22 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
3
States / cities
Louisville, Kentucky • Memphis, Tennessee • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Phase 4 Interventional

Personalized Real-Time DBS and PD Mechanisms

NCT06013956
View directory record Official record
Conditions
Parkinson Disease
Interventions
Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab
Device · Drug
Lead sponsor
David Escobar
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Enhancing Cognition in Older Adults

NCT03653351
View directory record Official record
Conditions
Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
Interventions
Active Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Sep 5, 2026, 10:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)

NCT03457675
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period
Device · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 70 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • Providence, Rhode Island • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation

NCT06782360
View directory record Official record
Conditions
Healthy, Cognitive Change, Effects of External Neurostimulation on Cognition
Interventions
Active Neurostimulation, Sham Stimulation
Device
Lead sponsor
OpenBCI
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

CARED : A Novel Rapid Treatment Paradigm for Depression

NCT07507370
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS)
Device · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 5, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

NCT02535702
View directory record Official record
Conditions
Normal Physiology
Interventions
In vivo MRS, fMRI, EEG/EOG, Stimulation tasks, NSPRD, Structural MRI
Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 5, 2026, 10:05 AM EDT