Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 29, 2026, 6:21 AM EDT

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Showing 1–24 of 96 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Septic Shock
Interventions
Low Level Transcutaneous Vagus Nerve Stimulation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Conditions
Acute Pain, Pain Perception, Healthy Adult Participants
Interventions
Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation, Cold pressor test
Device · Other
Lead sponsor
David A. Purger
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Vaping
Interventions
Active nVNS, Control nVNS
Device
Lead sponsor
Temple University
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Not listed Not applicable Interventional Accepts healthy volunteers

Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation

NCT04455295
Conditions
no Condition, Electroencephalography, Pupil Diameter
Interventions
Transdermal Vagus Nerve Stimulation (tVNS)
Device
Lead sponsor
Arkansas Tech University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Russellville, Arkansas
Completed Not applicable Interventional Results available

Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib

NCT04514757
Conditions
Atrial Fibrillation
Interventions
active tVNS, sham tVNS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 80 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Los Angeles, California • Oklahoma City, Oklahoma
Conditions
Juvenile Idiopathic Arthritis (JIA)
Interventions
Active tcVNS, Sham tcVNS
Device
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
5 Years to 18 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
7
States / cities
San Francisco, California • Orlando, Florida • Indianapolis, Indiana + 4 more
Conditions
Major Depressive Disorder
Interventions
active tVNS, Sham tVNS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

Mastoid taVNS-fMRI

NCT06518356
Conditions
Auricular Stimulation
Interventions
Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Active, not recruiting Not applicable Interventional

Noninvasive Vagal Nerve Stimulation

NCT06816004
Conditions
Multiple Sclerosis
Interventions
Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Results available

taVNS in Mild to Moderate Parkinson's Disease

NCT04157621
Conditions
Parkinson Disease
Interventions
Active taVNS, Sham Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vagus Nerve Stimulation and Stress Reduction Training for Migraine

NCT03592329
Conditions
Migraine
Interventions
Stress Reduction Training A, active tVNS, Stress Reduction Training B, sham tVNS
Behavioral · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Locus Coeruleus, Norepinephrine and Cognitive Aging

NCT06880510
Conditions
Alzheimer Disease
Interventions
t-VNS transcutaneous auricular vagus nerve stimulator
Device
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ithaca, New York
Conditions
Pain, Chronic, Irritable Bowel Syndrome, Symptom Cluster
Interventions
Home-based taVNS intervention
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 29 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Completed No phase listed Interventional Accepts healthy volunteers Results available

Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding

NCT05899413
Conditions
Vagus Nerve Stimulation
Interventions
Transcutaneous vagal nerve stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 39 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Conditions
Healthy Volunteers
Interventions
Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Placebo Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Conditions
Presbycusis
Interventions
transcutaneous auricular vagus nerve stimulation, Sham Control
Device
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Alcohol Withdrawal
Interventions
Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
Erin Takemoto
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Wernersville, Pennsylvania
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

NCT05421208
Conditions
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
Interventions
Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
Diagnostic Test
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Completed Not applicable Interventional Results available

Post-stroke Pain taVNS

NCT06456385
Conditions
Stroke, Pain
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Auricular Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Accepts healthy volunteers Results available

taVNS Cold Pressor

NCT05254080
Conditions
taVNS, Brain Stimulation
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Charleston, South Carolina
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

NCT06892340
Conditions
Motion Sickness
Interventions
Transcutaneous Auricular Neurostimulation device
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Recruiting Not applicable Interventional

tAN for First Responders

NCT07109349
Conditions
Mental Fatigue, Mental Stress
Interventions
Sparrow Link
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Dallas, Texas