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ClinicalTrials.gov public records Last synced Nov 7, 2026, 7:30 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 158 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Active vagus nerve stimulation Clear all

Conditions: Post-COVID-19 Syndrome, Postural Tachycardia Syndrome, Dysautonomia
Interventions: Non-invasive vagus nerve stimulation, Sham Intervention; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Aging
Interventions: Transcutaneous vagal nerve stimulation (tVNS), Cognitive training; Device · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 65 Years to 90 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Tucson, Arizona • Gainesville, Florida

Conditions: Acute Pain, Pain Perception, Healthy Adult Participants
Interventions: Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation, Cold pressor test; Device · Other
Lead sponsor: David A. Purger; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions: Sparrow Ascent tAN, Sparrow Ascent Active Sham; Device
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Cape Girardeau, Missouri

Conditions: Rheumatoid Arthritis
Interventions: SetPoint Medical Neurostimulation of the Cholinergic Anti-inflammatory Pathway System; Device
Lead sponsor: SetPoint Medical Corporation; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 4
States / cities: Aventura, Florida • Zephyrhills, Florida • Great Neck, New York + 1 more

Conditions: Heavy Menstrual Bleeding
Interventions: Sparrow Link, Sparrow Link (Sham); Device
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 14 Years to 45 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Stroke, Hemiparesis
Interventions: In Motion Rehabilitation Robot; Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 85 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Dyslexia
Interventions: active taVNS, sham taVNS; Device
Lead sponsor: University of Florida; Other
Eligibility: 10 Years to 12 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Nasogastric Tube Intubation
Interventions: Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator; Device
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Traumatic Brain Injury, Upper Extremity
Interventions: taVNS, FTP; Device · Other
Lead sponsor: Craig Hospital; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Englewood, Colorado

Conditions: Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
Interventions: Transcutaneous auricular vagus nerve stimulation, Sham device; Device
Lead sponsor: Northwell Health; Other
Eligibility: 3 Years to 17 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: New Hyde Park, New York • Philadelphia, Pennsylvania

Conditions: Systemic Lupus Erythematosus
Interventions: Active vagus nerve stimulation, Sham vagus nerve stimulation; Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: HIV Associated Polyneuropathy
Interventions: Transcutaneous Auricular Vagus Nerve Stimulation (AVNS); Device
Lead sponsor: University of Miami; Other
Eligibility: 50 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
Interventions: Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS); Device
Lead sponsor: Sima Mofakham; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Heavy Drinking
Interventions: Active RAVANS, Brief Mindfulness-Based Intervention; Device · Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 21 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Malden, Massachusetts

Conditions: Anxiety, Distress, Emotional, Effects of Vibration, Healthy
Interventions: Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS), Waitlist Control, Healthy Controls: Substudy Group III, Distressed Workers: Subgroup II; Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Chronic Migraine
Interventions: GammaCore Active Device, GammaCore Sham Device; Device
Lead sponsor: ElectroCore INC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 6
States / cities: San Francisco, California • Ann Arbor, Michigan • Springfield, Missouri + 3 more

Conditions: Diabetes Mellitus, Type 2
Interventions: Ultrasound Vagus Nerve Stimulation (DECIMA); Device
Lead sponsor: Aucta Technologies, Inc.; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Cerebrovascular Stroke, Upper Extremity Paresis
Interventions: Paired Vagus Nerve Stimulation, Rehabilitation; Device · Other
Lead sponsor: MicroTransponder Inc.; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 15
States / cities: Scottsdale, Arizona • Downey, California • Santa Monica, California + 12 more

Conditions: Alzheimer Disease, Aging
Interventions: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS); Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Parkinson Disease
Interventions: taVNS, Exercise; Device · Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 35 Years to 80 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Birmingham, Alabama

Conditions: Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease, Autonomic Nervous System Imbalance
Interventions: Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment; Device · Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 10 Years to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Interventions: Sparrow Fledging Therapy System, Sham Sparrow Fledging Therapy System; Device
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 33 Weeks to 1 Year
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 3
States / cities: Charleston, South Carolina • Dallas, Texas • San Antonio, Texas

Conditions: Auricular Stimulation
Interventions: Transcutaneous Auricular Neruostimulation (tAN); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

VNS for Long-COVID-19

Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults

tAN for PTSD and OUD in Buprenorphine Therapy

Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)

Delivering tAN to Reduce HMB: The LUNA Study

Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke

taVNS for Letter Learning in Dyslexia

Vagal Stimulator to Reduce Nasogastric Tube Use

Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury

taVNS for FRNS in Children

Transcutaneous Vagus Nerve Stimulation in SLE

Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy

Vagus Nerve Stimulation in Patients in Comatose State

Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers

Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers

Non-Invasive Neurostimulation for the Prevention of Chronic Migraine

Acute Study of Effect of Ultrasound Vagus Nerve Stimulation on Glycemia

Pivotal Study of VNS During Rehab After Stroke (VNS-REHAB)

Vagus Nerve Stimulation to Enhance Memory in Aging

Combining VNS With PT Interventions for Individuals With PD

Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome

Neurostimulation to Improve NOWS Outcomes

RM1 Project 2 - tAN fMRI