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Showing 1–24 of 595 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Adaptive Intervention Clear all
Completed Not applicable Interventional

Adaptive Interventions for Problem Drinkers

NCT02511808
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Brief Advice, Motivational Interviewing, Behavioral Self-Control Training
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 75 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Sep 8, 2026, 5:17 PM EDT
Recruiting Phase 4 Interventional

Enhancing Hypnotic Medication Discontinuation in Primary Care

NCT06435520
View directory record Official record
Conditions
Insomnia, Hypnotic Dependence
Interventions
Digital Cognitive Behavioral Therapy, Structured Medication Tapering
Behavioral
Lead sponsor
National Jewish Health
Other
Eligibility
21 Years and older
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Adaptive Intervention for Depression Among Latinos Living With HIV

NCT03668379
View directory record Official record
Conditions
Depression
Interventions
Augment w/mHealth, Maintenance, Switch to CBT & mHealth, Augment w/BAT & mHealth
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional

Telephone Counseling or Standard Care in Patients Who Have Completed Treatment for Stages I, II, or III Cervical Cancer

NCT00086242
View directory record Official record
Conditions
Cervical Cancer, Psychosocial Effects of Cancer and Its Treatment
Interventions
Psychosocial Telephone Counseling (PTC)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 120 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Sep 8, 2026, 5:17 PM EDT
Recruiting Not applicable Interventional

Shaping Tolerance for Delayed Rewards

NCT03457402
View directory record Official record
Conditions
Impulsivity
Interventions
Shaping Delay Tolerance
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
3 Years to 6 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Treatment for COVID-19 in High-Risk Adult Outpatients

NCT04354428
View directory record Official record
Conditions
COVID-19, SARS-CoV-2
Interventions
Ascorbic Acid, Hydroxychloroquine Sulfate, Azithromycin, Folic Acid, Lopinavir 200 MG / Ritonavir 50 MG [Kaletra]
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
289 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
6
States / cities
Chicago, Illinois • New Orleans, Louisiana • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimization of a New Adaptive Intervention to Increase COVID-19 Testing

NCT04757298
View directory record Official record
Conditions
COVID-19 Testing
Interventions
Navigation Services, Critical Dialogue, Brief Counseling, Referral and Digital Brochure
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
668 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 8, 2026, 5:17 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)

NCT06799702
View directory record Official record
Conditions
HIV Pre-exposure Prophylaxis, HEPATITIS C (HCV), Opioid Use Disorder
Interventions
Telehealth Behavioral Intervention for promoting HIV and HCV care and MOUD among Persons who inject drugs (PWID)
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Colbert, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing a Digital Intervention to Prevent Risky Health Behaviors

NCT06538922
View directory record Official record
Conditions
Substance Use
Interventions
Single Session Family Intervention
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
12 Years to 14 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Assessment of DHA On Reducing Early Preterm Birth

NCT02626299
View directory record Official record
Conditions
Preterm Birth
Interventions
Docosahexaenoic acid - 800mg/day, Docosahexaenoic acid - 200mg/day, Placebo
Drug · Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
3
States / cities
Kansas City, Kansas • Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Sep 8, 2026, 5:17 PM EDT
Recruiting No phase listed Observational

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

NCT06904365
View directory record Official record
Conditions
Uterine Cancer, Rectal Cancer, Colon Cancer, Breast Cancer, Lung Cancer, Sarcoma, Cervix Cancer, Head and Neck Cancer, Anal Cancer, Liver Cancer, Gastric Cancer, Bladder Cancer
Interventions
HyperSight cone beam computed tomography (CBCT) scan, ETHOS 2.0
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Web-based Physical Activity Intervention for Latinas

NCT03491592
View directory record Official record
Conditions
Inactivity
Interventions
Enhanced Physical Activity Intervention, Original Physical Activity Intervention
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional

Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence

NCT02602795
View directory record Official record
Conditions
Opiate Dependence, Sexually Transmitted Diseases, HIV
Interventions
Acceptance and Commitment Therapy, Information Motivation Behavioral Model
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Reducing High Risk Behavior in Treatment Court

NCT01481428
View directory record Official record
Conditions
Substance Abuse, HIV
Interventions
Computer-facilitated HIV intervention, Attention Control
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional

Virtual Reality, Debriefing and Chronic Pain

NCT05254509
View directory record Official record
Conditions
Chronic Pain
Interventions
Occupational Therapy, Occupational Therapy +Virtual Reality
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 8, 2026, 5:17 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

The University of Oregon ACCESS Project

NCT07264621
View directory record Official record
Conditions
School Attendance, School Climate, School Engagement, School Exclusion, Externalizing Behavior, Disparities, Teacher-student Relationships, Stress, Emotional Regulation, Depression
Interventions
Inclusive Skill-building Learning Approach (ISLA), Family Check-Up Online (FCU-O), FCU-Online with telehealth coaching
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
11 Years and older
Enrollment
1,440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
13
States / cities
Cottage Grove, Oregon • Eugene, Oregon • Springfield, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Sep 8, 2026, 5:17 PM EDT
Recruiting Not applicable Interventional

Eating Disorder Dynamic Intervention

NCT07600671
View directory record Official record
Conditions
Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding or Eating Disorder
Interventions
Eating Disorder Dynamic Intervention
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years to 70 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Active, not recruiting Not applicable Interventional

Screening in Trauma for Opioid Misuse Prevention - an Adaptive Intervention

NCT06527599
View directory record Official record
Conditions
Opioid Misuse, Trauma Injury
Interventions
Opioid Risk Monitoring (ORM), enhanced Trauma Care Coordination (eTCC), Pain Coping Skills Training - Brief (PCST-LITE), Standard Trauma Care Coordination (sTCC), Pain Coping Skills Training - Plus (PCST+), Pain Coping Skills Training - Maintenance (PCST-M)
Other · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study of Response-Driven Adaptive Radiation Therapy for Patients With Locally Advanced Non-Small Cell Lung Cancer

NCT02492867
View directory record Official record
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
Response-driven Adaptive Radiation Therapy, Carboplatin, Paclitaxel, FDG-PET, V/Q SPECT, Durvalumab
Radiation · Drug · Device
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Sep 8, 2026, 5:17 PM EDT
Recruiting Phase 2 Interventional

Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

NCT05317832
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
WI program, WI Program Reminder, JITAI Goal Setting, JITAI physical activity message, Notification EMA, End of day EMA, Wake up time EMA, Weekly PA Information, Daily PA Information
Behavioral · Other
Lead sponsor
Temple University
Other
Eligibility
18 Years to 75 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Results available

CPAP vs ASV for Insomnia

NCT02365064
View directory record Official record
Conditions
Insomnia, Sleep-Disordered Breathing
Interventions
AirCurve 10 ASV
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Sep 8, 2026, 5:17 PM EDT
Active, not recruiting Not applicable Interventional

Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial

NCT06976307
View directory record Official record
Conditions
Disabilities, Obesity and Overweight, Prediabetes
Interventions
High Carbohydrate Diet, Reduced Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Development of a Real-time Controller to Estimate Walking Performance Using a Bilateral Ankle Exoskeleton

NCT07393971
View directory record Official record
Conditions
Healthy Young Adults
Interventions
Adaptive Torque Control System for Ankle Exoskeleton
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 35 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 8, 2026, 5:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smart Reminders to Promote Home-based Cognitive Training

NCT05016856
View directory record Official record
Conditions
Adherence, Treatment
Interventions
Adherence Promotion With Person-centered Technology (APPT) System, Standard Reminder System (Active Control)
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
65 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Sep 8, 2026, 5:17 PM EDT