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ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:31 AM EDT

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Showing 1–24 of 73 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Advance directive Clear all
Completed Not applicable Interventional

Patient Understanding of End of Life Care

NCT01683097
View directory record Official record
Conditions
Advance Directives, Resuscitation Orders
Interventions
Standardized explanation
Other
Lead sponsor
Partners in Internal Medicine
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2012 · Synced Oct 21, 2026, 8:31 AM EDT
Active, not recruiting Not applicable Interventional

Group Advanced Care Planning Pilot for Veterans

NCT06646614
View directory record Official record
Conditions
Cancer
Interventions
Group Advance Care Planning Education
Behavioral
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Integrating Palliative Care Social Workers Into Sub-Acute Settings: A Feasibility Trial

NCT03546920
View directory record Official record
Conditions
Advanced Medical Illness
Interventions
ALIGN Intervention Phase
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
65 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 21, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

NCT04515810
View directory record Official record
Conditions
Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Hematologic Malignancy, Refractory Hematologic Malignancy
Interventions
Internet-Based Intervention, Best Practice, Telephone-Based Intervention, Questionnaire Administration, Post-intervention qualitative feedback interview
Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
4
States / cities
Manhasset, New York • New York, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Advance Directives Completion Rates and an Intervention to Address Health Literacy in a Clinic Population

NCT02702284
View directory record Official record
Conditions
Health Literacy
Interventions
Advance Directives, Advance Directives without assistance
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
51 Years and older
Enrollment
529 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 21, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional

A Palliative Care Model Impact on Knowledge and Attitudes

NCT06860932
View directory record Official record
Conditions
Multiple Sclerosis, MS
Interventions
Palliative care video comprises the conversation and advance directives., Palliative care written material
Behavioral
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support

NCT03323502
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
APPROACHES ACP Specialist Program, Standard of care
Behavioral · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
47,396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Warsaw, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of an Easy to Read Advance Directive Versus a Standard Advance Directive

NCT00328055
View directory record Official record
Conditions
Aging
Interventions
AD-Easy (Advance Directive-Easy), AD-Standard (Advance Directive-Standard)
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
50 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2011 · Synced Oct 21, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparing the Stanford Letter Project Form to Traditional Advance Directives

NCT02799537
View directory record Official record
Conditions
Advance Directives, Palliative Care
Interventions
Randomized clinical study
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)

NCT04281784
View directory record Official record
Conditions
Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive, Heart Failure，Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Lung Diseases, Interstitial, Peripheral Vascular Disease, Diabetes With End Organ Injury
Interventions
EHR-based Clinician Jumpstart
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
2,512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Patient-centered and Efficacious Advance Care Planning in Cancer: the PEACe Comparative Effectiveness Trial

NCT03824158
View directory record Official record
Conditions
Cancer, Advance Care Planning
Interventions
Facilitated advance care planning (in-person or telephonic), Web-based advance care planning
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
672 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing a Communication Intervention for People With Memory Challenges and Their Care Partners

NCT05143255
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
KNOW
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning

NCT06028152
View directory record Official record
Conditions
Breast Cancer, Lung Cancer, Genito Urinary Cancer
Interventions
End-of-life conversation game called "Hello"
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Project Power: An HIV Risk Reduction Intervention for Black Men Who Have Sex With Men and Women (BMSM/W)

NCT01376895
View directory record Official record
Conditions
Unsafe Sex, Risk Reduction
Interventions
PROJECT POWER, Power Health
Behavioral
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 11, 2014 · Synced Oct 21, 2026, 8:31 AM EDT
Not yet recruiting Not applicable Interventional

A Multi-Site Hybrid Type I Effectiveness-Implementation Randomized Trial of an Emergency Care Action Plan for Infants With Medical Complexity

NCT06993129
View directory record Official record
Conditions
Chronic Disease Management, Infants Health, Emergency, Utilization, Health Care, Caregiver Stress
Interventions
Emergency Care Action Plan
Other
Lead sponsor
University of Vermont
Other
Eligibility
0 Months to 6 Months
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
4
States / cities
Aurora, Colorado • Cincinnati, Ohio • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 21, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Telephone-Based Coaching Sessions (TAC) to Improve Advance Care Planning Participation in Advanced Cancer Patients and Their Support Person

NCT07141407
View directory record Official record
Conditions
Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
Interventions
Supportive Care, Telephone-Based Intervention, Survey Administration, Educational Intervention
Other · Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
3
States / cities
Everett, Washington • Mount Vernon, Washington • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness - Pilot Study

NCT03746392
View directory record Official record
Conditions
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure, Liver Failures, Chronic, Renal Insufficiency, Chronic, Dementia, Diabetes Complications, Peripheral Vascular Disease, Frail Elderly
Interventions
Jumpstart Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)

NCT04283994
View directory record Official record
Conditions
Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Lung Diseases, Interstitial, Peripheral Vascular Disease, Diabetes With End Organ Injury
Interventions
Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
756 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 21, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional

Resilience-Building for Advance Care Planning

NCT07428278
View directory record Official record
Conditions
Advanced Cancer, End of Life
Interventions
ROCKS, Usual Care
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 80 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 21, 2026, 8:31 AM EDT
Completed No phase listed Observational

Cardiopulmonary Resuscitation (CPR) Video to Enhance Advance Care Planning in Advanced Upper Gastrointestinal Cancer Patients

NCT01105806
View directory record Official record
Conditions
Pancreas and Hepatobiliary Cancer Patients
Interventions
(CPR) video and questionnaires, cardiopulmonary resuscitation (CPR) narrative script and questionnaires
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2015 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Study of Default Options in Advance Directives

NCT01817686
View directory record Official record
Conditions
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy, Congestive Heart Failure, NYHA Class IV or NYHA Class III Plus 1 Hospitalization in the Past Year, Malignancy, Any Stage 3B or 4 Solid Tumor
Interventions
Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
Other
Lead sponsor
Corporal Michael J. Crescenz VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2015 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Comparison of a Web-based Advance Directive to a Standard Advance Directive

NCT03676426
View directory record Official record
Conditions
GI Cancer, Thoracic Cancer
Interventions
Web platform for advance care planning/advance directive, Standard advance directive
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2020 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

The Influence of Default Options in Advance Directives

NCT01346176
View directory record Official record
Conditions
Advance Care Planning
Interventions
Advance Directive Forms
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
50 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 3, 2016 · Synced Oct 21, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

NCT06384417
View directory record Official record
Conditions
Breast Cancer, Lung Cancer, Genito-Urinary Cancer, Colorectal Cancer, Gastric Cancer, Pancreatic Cancer, Liver Cancer, Head and Neck Cancer, Melanoma
Interventions
Hello for Cancer game, Table Topics game
Behavioral · Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 21, 2026, 8:31 AM EDT