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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Alpha-stim Clear all
Recruiting Not applicable Interventional

Non-invasive Cranial Electrical Stimulation for Mealtime Anxiety in Adults With Eating Disorders

NCT07017322
View directory record Official record
Conditions
Eating Disorders, Anxiety
Interventions
Alpha-Stim AID
Device
Lead sponsor
Rogers Behavioral Health
Other
Eligibility
18 Years to 30 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Oconomowoc, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electrotherapy Stimulation and Acute Stress

NCT06034496
View directory record Official record
Conditions
Anxiety State
Interventions
Active CES, Sham CES
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years to 40 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Medford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional

Combining CES Alpha-Stim and InterX for Optimized Rehabilitation Following Extremity Immobilization

NCT03060122
View directory record Official record
Conditions
Neuropathic Pain
Interventions
NIN, Sham CES, CES
Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Results available

Cranial Electrotherapy Stimulation (CES) Therapy

NCT02453347
View directory record Official record
Conditions
TBI, Anxiety, PTSD, Depression
Interventions
CES Therapy
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older · Male only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2018 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Results available

Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia

NCT00928720
View directory record Official record
Conditions
Fibromyalgia
Interventions
CES device, sham device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness of CES on Emotional and Cellular Wellbeing

NCT03369418
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Alpha-Stim Active, Alpha-Stim Inactive
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Sep 3, 2026, 12:16 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.

NCT02846740
View directory record Official record
Conditions
Suicide, Depression, Anxiety, Insomnia, Agitation
Interventions
Alpha-Stim®., Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale
Device · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of CES for Fibromyalgia

NCT04115033
View directory record Official record
Conditions
Fibromyalgia
Interventions
Alpha-stim
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional

Cranial Electrotherapy for Military Beneficiaries With Restless Legs Syndrome

NCT02419014
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Active CES Device Alpha-Stim®, Sham Device
Device
Lead sponsor
Tripler Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Results available

The Efficacy of Cranial Electrostimulating Therapy for Depression and Anxiety Among Homeless Adults

NCT02732561
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Alpha Stim device, Sham device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 3, 2026, 12:16 AM EDT
Active, not recruiting Not applicable Interventional

Novel Mental Health Therapies to Improve Military Readiness

NCT05887713
View directory record Official record
Conditions
Anxiety, Alpha Stim, Cranial Electrotherapy Stimulation, Cognitive Behavioral Therapy, Heart Rate Variability
Interventions
Experimental: Alpha-Stim 100, Sham Comparator
Device
Lead sponsor
David Moss
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 3, 2026, 12:16 AM EDT
Not listed Not applicable Interventional

Using NI-ES to Treat Spinal Cord Injury (SCI)

NCT04097015
View directory record Official record
Conditions
Spinal Cord Injuries, Pain, Neuropathic
Interventions
Alpha-Stim M
Device
Lead sponsor
SCI Research Advancement
Other
Eligibility
Not listed
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Buellton, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 3, 2026, 12:16 AM EDT
Recruiting Not applicable Interventional

Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome

NCT07151248
View directory record Official record
Conditions
Gulf War Syndrome
Interventions
Cranial electrical/electrotherapy stimulation (CES), Sham Cranial electrical/electrotherapy stimulation (CES)
Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 3, 2026, 12:16 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

New Mothers Alpha-Stim

NCT04770181
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Results available

Self Cranial Electrical Stimulation (CES) for Pain in Older Adults With Knee Osteoarthritis (Self CES for Knee Pain)

NCT04016259
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cranial Electrical Stimulation (CES), Sham-CES
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
50 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2020 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional

Cranial Electrotherapy Stimulation in the Treatment of Posttraumatic Stress Disorder

NCT03757494
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Alpha Stim
Device
Lead sponsor
White River Junction Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
White River Junction, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electrotherapy Stimulation: Piloting a Road to PTSD Prevention in First Responders

NCT06203717
View directory record Official record
Conditions
Adults, Firefighters
Interventions
Alpha-Stim AID cranial electrotherapy stimulation
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 56 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Phase 4 Interventional

Use of Alpha-Stim Cranial-electrotherapy Stimulation (CES) in the Treatment of Anxiety

NCT01533415
View directory record Official record
Conditions
Anxiety
Interventions
CES treatment using Alpha-Stim technology, Shame CES Treatment
Device
Lead sponsor
Wyndhurst Counseling Center
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
2
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 8, 2013 · Synced Sep 3, 2026, 12:16 AM EDT
Terminated Phase 4 Interventional Results available

Cranial Electro Therapy Stimulation in Reducing Perioperative Anxiety

NCT00928772
View directory record Official record
Conditions
Anxiety
Interventions
CRANIAL ELECTROTHERAPY (Alpha Stim) + SHAM MIDAZOLAM, MIDAZOLAM + SHAM ELECTRODES SIMULATING CRANIAL ELECTROTHERAPY, NO SEDATION WITH SHAM CRANIAL ELECTROSTIMULATION AND PLACEBO VERSED
Device · Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
50 Years to 90 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 3, 2026, 12:16 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of CES in New Mothers During the Post Partum Period

NCT03210155
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2020 · Synced Sep 3, 2026, 12:16 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive Disorder

NCT03222752
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cranial Electrotherapy Stimulation, Sham Cranial Electrotherapy Stimulation
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Forest, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 3, 2026, 12:16 AM EDT
Not listed Not applicable Interventional

Cranial Electrotherapy Stimulation (CES) for Soldiers With Combat-Related Symptoms

NCT00866411
View directory record Official record
Conditions
Combat Related Symptoms, Irritability, Anger
Interventions
cranial electrotherapy stimulation (CES) with Alpha-Stim, placebo
Procedure
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 19, 2009 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Phase 2 Interventional Results available

Cranial Electrotherapy Stimulation in Burned Patients

NCT00723008
View directory record Official record
Conditions
Post Traumatic Stress Disorders, Burns
Interventions
Alpha Stim 100 (Cranial Electrotherapy Stimulation)
Device
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Sep 3, 2026, 12:16 AM EDT
Completed Not applicable Interventional

CES for the Treatment of GAD in Young Adults

NCT06124014
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
At-Home Stimulation
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
18 Years to 21 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 3, 2026, 12:16 AM EDT