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ClinicalTrials.gov public records Last synced Oct 2, 2026, 3:22 PM EDT

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Showing 25–41 of 41 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Amitiza (Lubiprostone) Clear all
Completed Phase 3 Interventional

Evaluation of Clinical Equivalence Between Two Lubiprostone Products in the Treatment of Chronic Idiopathic Constipation

NCT01674530
View directory record Official record
Conditions
Chronic Idiopathic Constipation
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Dr. Reddy's Laboratories Limited
Industry
Eligibility
18 Years and older
Enrollment
909 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
93
States / cities
Birmingham, Alabama • Dothan, Alabama • Huntsville, Alabama + 71 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2014 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Not applicable Interventional Results available

Lubiprostone as a Treatment for Constipation in Parkinson's Disease

NCT00669461
View directory record Official record
Conditions
Constipation, Parkinson's Disease
Interventions
Lubiprostone
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Dec 30, 2016 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Lubiprostone and Mucus Secretion in Patients With Chronic Constipation

NCT01447849
View directory record Official record
Conditions
Constipation
Interventions
lubiprostone, placebo
Drug
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Not applicable Interventional Results available

Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation

NCT01162863
View directory record Official record
Conditions
Irritable Bowel Syndrome, Constipation
Interventions
Lubiprostone, Placebo, Smartpill wireless motility capsule
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 27, 2017 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Not applicable Interventional Results available

Effect of Lubiprostone on Small Bowel Contractions in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)

NCT01085643
View directory record Official record
Conditions
Constipation-predominant Irritable Bowel Syndrome
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2011 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy

NCT00611442
View directory record Official record
Conditions
Bowel Preparation for Colonoscopy
Interventions
lubiprostone, placebo
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2012 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Comparative Pharmacokinetics and Food-Effect Bioavailability of Lubiprostone Sprinkle in Healthy Volunteers

NCT03010631
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Cohort 1: Lubiprostone Capsule, Fasted, Cohort 1: Lubiprostone Sprinkle Formulation, Fasted, Cohort 2: Lubiprostone Sprinkle Formulation, Fed, Cohort 2: Lubiprostone Sprinkle Formulation, Fasted
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 4 Interventional Results available

The Effectiveness of Lubiprostone in Constipated Diabetics

NCT01170039
View directory record Official record
Conditions
Constipation, Diabetes
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
30 Years to 80 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 15, 2016 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional Results available

Pharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects With Chronic Idiopathic Constipation

NCT01993875
View directory record Official record
Conditions
Chronic Idiopathic Constipation
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
11
States / cities
Anniston, Alabama • Anaheim, California • DeLand, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2019 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional Results available

Lubiprostone for Children With Constipation

NCT02138136
View directory record Official record
Conditions
Constipation - Functional
Interventions
Lubiprostone
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
6 Years to 17 Years
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
67
States / cities
Mobile, Alabama • Phoenix, Arizona • Fayetteville, Arkansas + 60 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 4 Interventional Results available

Amitiza in Constipation Associated With PD (Parkinson's Disease)

NCT00908076
View directory record Official record
Conditions
Parkinson's Disease
Interventions
LUBIPROSTONE
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Tampa, Florida • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 29, 2022 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional Results available

Opioid-induced Bowel Dysfunction Pivotal Assessment of Lubiprostone

NCT00597428
View directory record Official record
Conditions
Opioid-Induced Bowel Dysfunction
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
18 Years and older
Enrollment
437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
109
States / cities
Tuscaloosa, Alabama • Phoenix, Arizona • Tempe, Arizona + 93 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Oct 2, 2026, 3:22 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

NCT04361656
View directory record Official record
Conditions
Colonoscopy Preparation
Interventions
PEG-ELS current standard of care, PEG-ELS current standard of care plus Lubiprostone 24 microgram Oral Cap (x2)
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Novi, Michigan • Southfield, Michigan • Warren, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional Results available

Lubiprostone in Children With Functional Constipation

NCT02042183
View directory record Official record
Conditions
Constipation - Functional
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
6 Years to 17 Years
Enrollment
606 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
87
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 78 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2020 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Phase 2 Interventional Results available

Evaluation of the Efficacy and Safety of Lubiprostone in Adults With Mixed or Unsubtyped Irritable Bowel Syndrome

NCT02544152
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
16
States / cities
Huntsville, Alabama • North Little Rock, Arkansas • Chula Vista, California + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2019 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional

Evaluation of Clinical Equivalence Between Two Lubiprostone Products

NCT01372423
View directory record Official record
Conditions
Chronic Idiopathic Constipation
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Anchen Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
808 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
79
States / cities
Dothan, Alabama • Huntsville, Alabama • Mobile, Alabama + 76 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2012 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications

NCT01096290
View directory record Official record
Conditions
Constipation
Interventions
lubiprostone, Matched placebo
Drug
Lead sponsor
University of South Alabama
Other
Eligibility
19 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 2, 2026, 3:22 PM EDT