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Conditions: Healthy, Drug Interactions
Interventions: Cranberry juice and capsules; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 50 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Immune Surveillance, Stem Cell Surveillance
Interventions: A low dose of seaweed extract, A high dose of seaweed extract, Placebo; Dietary Supplement
Lead sponsor: Natural Immune Systems Inc; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Klamath Falls, Oregon

Conditions: Critical Illness, Sepsis, Multiple Organ Failure
Interventions: Glutamine, Antioxidants, Glutamine + Antioxidants, Placebo; Other
Lead sponsor: Daren K. Heyland; Other
Eligibility: 18 Years and older
Enrollment: 1,223 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 5
States / cities: Aurora, Colorado • Louisville, Kentucky • Dayton, Ohio + 2 more

Conditions: Ovarian Cancer
Interventions: Oral Ascorbic Acid, Paclitaxel, Carboplatin, Sodium Ascorbate, Oral Mixed natural Carotenoids with Vitamin A, Vitamin E; Dietary Supplement · Drug
Lead sponsor: Jeanne Drisko, MD, CNS, FACN; Other
Eligibility: 18 Years and older · Female only
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2007
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Asthma, Lung Function Decreased, Food Allergy, Allergic Sensitisation, Allergic Rhinitis, COPD, Atopy
Interventions: Dietary intake of various nutrients, foods and biocompounds; Other
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 15 Years to 75 Years
Enrollment: 3,500 participants
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Chronic Fatigue Syndrome
Interventions: Hydrogen water which is prepared from an OTC supplement.; Dietary Supplement
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Precancerous Condition, Prostate Cancer
Interventions: immunoenzyme technique, laboratory biomarker analysis; Other
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 45 Years to 65 Years · Male only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 3
States / cities: Cleveland, Ohio

Conditions: Hypertension
Interventions: Oral Antioxidant, Exercise rehabilitation; Dietary Supplement · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 60 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Epilepsy in Children, Epilepsy in Youth, Randomized Controlled Trial, Refractory Epilepsy, Diet Intervention
Interventions: Low Glutamate diet; Other
Lead sponsor: American University; Other
Eligibility: 2 Years to 21 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Diastolic Heart Failure, Hypertensive Heart Disease, Heart Failure With Preserved Ejection Fraction, Hypertension, Oxidative Stress
Interventions: grape seed extract (MegaNatural BP, Polyphenolics, Inc.); Drug
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Cold Exposure
Interventions: Mitoquinone mesylate (MitoQ), Placebo, Cold Water Hand Immersion, Cold Air Exposure; Dietary Supplement · Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 18 Years to 40 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Alzheimer's Disease, Oxidative Stress, Dementia, Hyperlipidemia, Inflammation
Interventions: Fish Oil, Lipoic Acid, Fish Oil Placebo, Lipoic Acid Placebo; Dietary Supplement · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 55 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Impaired Glucose Tolerance, Prediabetic State
Interventions: Aspirin, Alpha lipoic acid, Olmesartan, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness, Immune Function, Gut Health, Microbiome Analysis, Exercise Performance, Exercise Metabolism
Interventions: Postbiotic Active Lifestyle Blend, Placebo; Dietary Supplement · Other
Lead sponsor: Lindenwood University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Saint Charles, Missouri

Conditions: Schizophrenia
Interventions: Olanzapine, Omega 3, Vitamin E+C; Drug
Lead sponsor: Augusta University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2005
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Early Memory Loss, Mild Cognitive Impairment, Alzheimer's Disease, Vascular Dementia
Interventions: CerefolinNAC®; Other
Lead sponsor: Pamlab, Inc.; Industry
Eligibility: 50 Years to 80 Years
Enrollment: 204 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Hickory, North Carolina

Conditions: Cerebrovascular Disorders
Interventions: Antioxidant Cocktail, Placebo; Dietary Supplement · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Tetrahydrobiopterin (BH4), Antioxidant Cocktail; Drug · Dietary Supplement
Lead sponsor: Augusta University; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
Interventions: Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME, Norepinephrine + L-NAME + Ascorbic Acid; Drug
Lead sponsor: The University of Texas at Arlington; Other
Eligibility: 18 Years to 35 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Arlington, Texas

Conditions: Inflammation, Atherosclerosis, Cardiovascular Disease
Interventions: PolyResveratrol Supplementation, Curcumin Supplementation; Dietary Supplement
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 60 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Center-involved Diabetic Macular Edema (CI-DME)
Interventions: Diabetes Visual Function Study (DiVFuSS) softgels, canola oil placebo softgels, 2 per day; Dietary Supplement · Other
Lead sponsor: ZeaVision, LLC; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Olympia, Washington • Tacoma, Washington

Conditions: Lung Disease
Interventions: Not listed
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 18 Years to 30 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1998 – 2003
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Healthy Humans
Interventions: Beverage made to look like the cranberry beverage, Beverage made from cranberry compounds; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 50 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Graft Occlusion, Vascular, Coronary Restenosis, Atherosclerosis
Interventions: BO-653; Drug
Lead sponsor: Chugai Pharma USA; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 29
States / cities: Phoenix, Arizona • Tucson, Arizona • Burlingame, California + 24 more

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Drug Interactions and Bioavailability of Cranberry

Rapid Effects on Antioxidant Status, Immune Alertness, and Regenerative Activity

Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients

Treatment of Newly Diagnosed Ovarian Cancer With Antioxidants

Dietary Intake in Adults From the GA2LEN Folow-up Survey

Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS

Study of Blood Samples From Older Patients at High Risk of Developing Prostate Cancer and From Healthy Male Participants

Understanding the Exercise-Hypertension Paradox

The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy

Physiological Effects of Grape Seed Extract in Diastolic Heart Failure

The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold

Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease

Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance

A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance

Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids

NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)

HYPEROXIA Responses and ROS

Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease

Local Antioxidant Therapy Vasoconstriction Effects in Different Races

Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL

Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema

Ozone Exposure and Dose Delivered to Human Lungs

Cranberry Enhances Human Immune Function and Reduces Illness

A Blinded Study Conducted at Multiple Centers Evaluating Various Doses of an Investigational Agent (BO-653) Against Placebo, for Safety and Effectiveness in Preventing Post-Angioplasty Blood Vessel Re-Closure (Restenosis) in Stented Vessels.