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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Aortic valve replacement Clear all
Terminated Not applicable Interventional

ATS 3f(r) Aortic Bioprosthesis Model 1000, 19mm

NCT00657826
View directory record Official record
Conditions
Heart Valve Diseases
Interventions
ATS 3f® Aortic Bioprosthesis, Model 1000, 19mm
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2015
U.S. locations
1
States / cities
Wynnewood, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2016 · Synced Sep 26, 2026, 5:33 PM EDT
Recruiting Not applicable Interventional

Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure

NCT07205068
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Shockwave M5 IVL Catheter, Modified Seldinger Technique
Device · Procedure
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 26, 2026, 5:33 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

NCT04268160
View directory record Official record
Conditions
Glutathione Peroxidase Activity, Aortic Stenosis, Transcatheter Aortic Valve Replacement
Interventions
Blood draw to measure GPx activity, Blood draw to measure SOD activity, Blood draw to measure Lp(a) levels
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Sep 26, 2026, 5:33 PM EDT
Completed No phase listed Observational

Post-Market Surveillance Registry to Monitor Performance and Safety of V8 Device

NCT02099942
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
V8 Balloon Aortic Valvuloplasty (BAV) Catheter
Device
Lead sponsor
InterValve, Inc.
Industry
Eligibility
Not listed
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
7
States / cities
Los Angeles, California • Minneapolis, Minnesota • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Sep 26, 2026, 5:33 PM EDT
Not listed Not applicable Interventional Results available

JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study

NCT02732691
View directory record Official record
Conditions
Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction
Interventions
JenaValve Pericardial TAVR System
Device
Lead sponsor
JenaValve Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Sep 26, 2026, 5:33 PM EDT
Recruiting No phase listed Observational

Valved Graft PMCF Study

NCT04754217
View directory record Official record
Conditions
Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
Interventions
VAVGJ, CAVGJ
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
5
States / cities
Birmingham, Alabama • Ann Arbor, Michigan • Asheville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 26, 2026, 5:33 PM EDT
Active, not recruiting No phase listed Observational

SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy

NCT03924661
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Aortic Valve Replacement
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
9
States / cities
Los Angeles, California • Madera, California • Sacramento, California + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve

NCT01514162
View directory record Official record
Conditions
Heart Valve Diseases
Interventions
Trifecta valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
Minneapolis, Minnesota • Rochester, Minnesota • Asheville, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

NCT02097420
View directory record Official record
Conditions
Mitral Valve Disease, Damaged Mitral Valve, Malfunctioning Mitral Heart Valve, Mitral Valve Replacement
Interventions
Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Up to 5 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
24
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Phase 1 Interventional

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

NCT02280824
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
CA-TAVR, Amplatzer Duct Occluder
Procedure · Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 99 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
15
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Evanston, Illinois + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

COMMENCE Pulmonary: Clinical Evaluation of Edwards Pericardial Aortic Bioprosthesis (Model 11000A) for Pulmonary Valve Replacement

NCT02656290
View directory record Official record
Conditions
Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration, Congenital Pulmonary Valve Abnormality
Interventions
Edwards Pericardial Aortic Bioprosthesis Model 11000A
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
5 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Sep 26, 2026, 5:33 PM EDT
Not listed Not applicable Interventional

Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial

NCT05230225
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Physician Notification Letter
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Sep 26, 2026, 5:33 PM EDT
Active, not recruiting Not applicable Interventional

Early Feasibility Study for the Foldax Tria Aortic Heart Valve

NCT03851068
View directory record Official record
Conditions
Aortic Valve Disease, Aortic Valve Stenosis
Interventions
Foldax Tria Aortic Valve
Device
Lead sponsor
Foldax, Inc
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
5
States / cities
Indianapolis, Indiana • Wichita, Kansas • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 26, 2026, 5:33 PM EDT
Completed No phase listed Observational

Balloon Aortic Valvuloplasty During Surgical Aortic Valve Replacement

NCT00584116
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Not listed
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 26, 2026, 5:33 PM EDT
Terminated Not applicable Interventional Results available

On-X Heart Valve - 17mm Aortic and 23mm Mitral

NCT01812174
View directory record Official record
Conditions
Heart Valve Disease
Interventions
17mm aortic valve (On-X ), 23mm mitral valve (On-X)
Device
Lead sponsor
On-X Life Technologies, Inc.
Industry
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
7
States / cities
Little Rock, Arkansas • Portland, Maine • Las Vegas, Nevada + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 26, 2026, 5:33 PM EDT
Completed No phase listed Observational

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

NCT04827238
View directory record Official record
Conditions
Aortic Stenosis, Aortic Valve Stenosis
Interventions
Standardized Invasive Hemodynamics
Diagnostic Test
Lead sponsor
University of British Columbia
Other
Eligibility
Not listed
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Tucson, Arizona • Boca Raton, Florida • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 26, 2026, 5:33 PM EDT
Terminated Not applicable Interventional Results available

CarboMedics Top Hat vs St. Jude Medical Regent Valve Comparing Sizing and Hemodynamics

NCT00619151
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Top Hat, Regent
Device
Lead sponsor
Sorin Group USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
Baltimore, Maryland • Kingsport, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation

NCT01694563
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Interventions
Synergy Ablation System
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
49
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Los Angeles, California + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Conduction Disease After Transcatheter Aortic Valve Replacement

NCT04489095
View directory record Official record
Conditions
Aortic Stenosis, Heart Block, Aortic Insufficiency
Interventions
Electrophysiology Study
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 13, 2022 · Synced Sep 26, 2026, 5:33 PM EDT
Terminated No phase listed Observational

Sorin Universal REgistry on Aortic Valve Replacement

NCT02679404
View directory record Official record
Conditions
Aortic Valve Disease, Aortic Stenosis
Interventions
Not listed
Lead sponsor
Corcym S.r.l
Industry
Eligibility
18 Years and older
Enrollment
2,758 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
5
States / cities
Birmingham, Alabama • Jacksonville, Florida • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan

NCT01843426
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis

NCT02628899
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Transfemoral TAVR, SAVR
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
Not listed
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
11
States / cities
Sacramento, California • San Diego, California • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

Comparing Perclose to Statseal With Perclose in Transcatheter Aortic Valve Replacement Arteriotomy Closure

NCT05637970
View directory record Official record
Conditions
Arterial Occlusion, Cardiovascular Diseases, Hematoma
Interventions
Perclose, Statseal
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2025 · Synced Sep 26, 2026, 5:33 PM EDT