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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Appendectomy Clear all
Terminated Phase 2 Interventional Results available

Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies

NCT01575028
View directory record Official record
Conditions
Appendicitis
Interventions
Ropivacaine, Bupivacaine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Sep 5, 2026, 2:15 AM EDT
Recruiting No phase listed Observational

Retrospective Acute Care Appendectomy Study

NCT06624215
View directory record Official record
Conditions
Acute Appendicitis
Interventions
Appendectomy
Procedure
Lead sponsor
Intuitive Surgical
Industry
Eligibility
22 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Columbus, Ohio • Portland, Oregon • New Braunfels, Texas
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Phase 3 Interventional

Early Versus Interval Appendectomy for Ruptured Appendicitis in Children

NCT00435032
View directory record Official record
Conditions
Ruptured Appendicitis
Interventions
early appendectomy, interval appendectomy
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
Up to 18 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Sep 5, 2026, 2:15 AM EDT
Terminated Not applicable Interventional

Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children

NCT00540189
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Initial appendectomy, Interval appendectomy
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
2 Years to 17 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 18, 2016 · Synced Sep 5, 2026, 2:15 AM EDT
Terminated Not applicable Interventional

Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)

NCT05838248
View directory record Official record
Conditions
Appendicitis
Interventions
antibiotic duration
Other
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional Results available

The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial

NCT02800785
View directory record Official record
Conditions
Appendicitis
Interventions
Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin, Appendectomy
Drug · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
25
States / cities
Sylmar, California • Torrance, California • Aurora, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 5, 2026, 2:15 AM EDT
Not listed No phase listed Observational

Multi-institutional Trial of Non-operative Management of Appendicitis

NCT02271932
View directory record Official record
Conditions
Appendicitis
Interventions
Non-operative
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
8 Years to 17 Years · Male only
Enrollment
1,076 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional Results available

Wound Infection Alexis Wound Retractor

NCT00323453
View directory record Official record
Conditions
Appendicitis
Interventions
Open appendectomy using Alexis Wound Retractor followed by standardized wound closure, Open appendectomy with standardized wound closure
Device · Procedure
Lead sponsor
Santa Barbara Cottage Hospital
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional

Virtual Reality for Appendectomy Pain

NCT04357132
View directory record Official record
Conditions
Appendix Rupture, Pain, Pain, Postoperative
Interventions
VR-Biofeedback, VR-Distraction
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 18 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 5, 2026, 2:15 AM EDT
Completed No phase listed Observational

TICAP - Titanium Clips for Appendiceal Stump Closure

NCT01734837
View directory record Official record
Conditions
Appendicitis
Interventions
DS-Ligature Clip
Device
Lead sponsor
Aesculap AG
Industry
Eligibility
16 Years and older
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Marina del Rey, California • Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 8, 2015 · Synced Sep 5, 2026, 2:15 AM EDT
Not listed No phase listed Observational

Minimally Invasive Surgery: Using Natural Orifice Translumenal Endoscopic Surgery (NOTES)

NCT00531219
View directory record Official record
Conditions
Appendicitis, Cholelithiasis
Interventions
Transgastric Appendectomy, Transgastric Cholecystectomy
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 5, 2026, 2:15 AM EDT
Withdrawn Not applicable Interventional

Hybrid Transvaginal-Transabdominal Endoscopic Surgery

NCT01039129
View directory record Official record
Conditions
Gallstones, Appendicitis, Pelvic Pain
Interventions
Endoscopic Cholecystectomy, Endoscopic Appendectomy, Endoscopic Peritoneoscopy
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 60 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Sep 5, 2026, 2:15 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

NCT06354699
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Telethon Kids Institute
Other
Eligibility
Up to 16 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
7
States / cities
San Francisco, California • Aurora, Colorado • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 5, 2026, 2:15 AM EDT
Not listed No phase listed Observational

Non-operative Management of Early Appendicitis in Children

NCT01718275
View directory record Official record
Conditions
Appendicitis
Interventions
Not listed
Lead sponsor
Peter Minneci
Other
Eligibility
7 Years to 17 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional

Transvaginal Appendectomy

NCT00806429
View directory record Official record
Conditions
Appendicitis
Interventions
transvaginal appendectomy
Procedure
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional

A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine

NCT03004222
View directory record Official record
Conditions
Laparoscopic Appendectomy
Interventions
Bupivacaine, Placebos
Drug
Lead sponsor
Metro Health, Michigan
Other
Eligibility
18 Years and older
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Wyoming, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional

Comparative Study of Laparoscopic Versus Open Appendectomy in Children

NCT00554008
View directory record Official record
Conditions
Appendicitis
Interventions
laparoscopic appendectomy, open appendectomy
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
Up to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Los Angeles, California • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 29, 2012 · Synced Sep 5, 2026, 2:15 AM EDT
Active, not recruiting Phase 1 Interventional

Precision Antibiotic Dosing for Appendectomy

NCT06860802
View directory record Official record
Conditions
Appendicitis (Diagnosis)
Interventions
Cefoxitin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional Results available

Fast Track Appendectomy for Suppurative Appendicitis

NCT02137603
View directory record Official record
Conditions
Suppurative Appendicitis
Interventions
Patients discharged home the same day following appendectomy
Other
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
5 Years to 18 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Water And Saline Head-to-head In The Blinded Evaluation Study Trial

NCT02714023
View directory record Official record
Conditions
Acute Appendicitis, Abscess
Interventions
Normal Saline, Sterile Water
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
6 Years and older
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 14, 2018 · Synced Sep 5, 2026, 2:15 AM EDT
Completed No phase listed Observational

Minimally Invasive Surgery: Using Natural Orfices

NCT00530998
View directory record Official record
Conditions
Appendicitis, Cholelithiasis, Gallstones
Interventions
Transvaginal Appendectomy, Transvaginal Cholecystectomy
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 5, 2026, 2:15 AM EDT
Completed Not applicable Interventional

Early Versus Delayed Operation for Perforated Appendicitis

NCT00414375
View directory record Official record
Conditions
Appendiceal Abscess
Interventions
Operation on Admission, Drainage and Interval Appendectomy
Procedure
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
Up to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 2, 2009 · Synced Sep 5, 2026, 2:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Minimally Invasive Surgery (MIS) Database for the Purpose of Research

NCT00535990
View directory record Official record
Conditions
Morbid Obesity, Hernia, Colorectal Cancer, Laparoscopy
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2021 · Synced Sep 5, 2026, 2:15 AM EDT
Terminated Not applicable Interventional Results available

Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients

NCT04748120
View directory record Official record
Conditions
Covid19, Appendicitis, Cholecystitis, Acute, Cholecystitis; Gallstone, Cholecystitis
Interventions
Operative management, Non-operative management
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 5, 2026, 2:15 AM EDT