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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:18 AM EDT

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Showing 25–48 of 1,303 matching trials from the live ClinicalTrials.gov search.
Completed Phase 1 Interventional Accepts healthy volunteers

Multimodal Sleep Pathway for Shoulder Arthroplasty

NCT03269760
Conditions
Sleep Disturbance, Shoulder Arthritis, Arthroplasty Complications, Perioperative/Postoperative Complications
Interventions
Zolpidem
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Francisco, California
Conditions
Trigger Point Pain, Myofascial
Interventions
Trigger point injection (lidocaine), Sham Comparator
Drug · Other
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, California
Active, not recruiting Not applicable Interventional

Episealer® Knee System IDE Clinical Study

NCT04000659
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
Episealer Knee System, Microfracture
Device · Procedure
Lead sponsor
Episurf Medical Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
8
States / cities
Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more
Conditions
Osteoarthritis; Rheumatoid Arthritis; Post Traumatic Arthritis
Interventions
Primary Uncemented Total Hip Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
21 Years and older
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
5
States / cities
Grand Rapids, Michigan • New York, New York • Gastonia, North Carolina + 2 more
Conditions
Rotator Cuff Tear, Proximal Humerus Fractures, Malunions, Chronic Proximal Humerus Dislocations
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
50 Years to 90 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Active, not recruiting No phase listed Observational

Optetrak Knee System Post Market Clinical Follow-Up

NCT05788757
Conditions
Knee Arthroplasty, Total
Interventions
Optetrak Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
4,588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2034
U.S. locations
3
States / cities
Worcester, Massachusetts • Las Vegas, Nevada • Charleston, South Carolina
Conditions
Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease, Musculoskeletal Disease, Prosthesis-Related Infections, Infection, Postoperative Complications, Pathologic Processes
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
Device
Lead sponsor
KCI USA, Inc
Industry
Eligibility
22 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
17
States / cities
Weston, Florida • Tucker, Georgia • New Orleans, Louisiana + 10 more
Conditions
Osteoarthritis, Osteoarthritis Thumb Base Joint, Carpometacarpal Osteoarthritis, Thumb
Interventions
CTM, Placebo
Device · Other
Lead sponsor
Indiana Hand to Shoulder Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Journey II CR Total Knee System
Interventions
Total knee arthroplasty with Journey II CR Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
586 participants
Timeline
2019 – 2020
U.S. locations
6
States / cities
Scottsdale, Arizona • Pikeville, Kentucky • Reno, Nevada + 3 more
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers

Adductor Canal Block

NCT04513145
Conditions
Osteoarthritis, Total Knee Replacement
Interventions
Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
Drug · Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
30 Years to 85 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Conditions
Total Knee Arthroplasty
Interventions
Fixed bearing total knee arthroplasty, Rotating platform total knee arthroplasty
Device
Lead sponsor
William Hopkinson
Other
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2021
U.S. locations
1
States / cities
Maywood, Illinois
Conditions
Obstructive Sleep Apnea, Total Knee Arthroplasty
Interventions
Not listed
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 90 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Diego, California
Enrolling by invitation No phase listed Observational

Persona SoluTion PPS Femur PMCF

NCT07286513
Conditions
Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle, Valgus Deformity, Varus Deformity, Flexion Deformity of Knee
Interventions
Total knee arthroplasty
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2037
U.S. locations
3
States / cities
Denver, Colorado • Louisville, Kentucky • Baltimore, Maryland
Conditions
Knee Arthroplasty
Interventions
Total Knee Replacement, Deuce
Device
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
30 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Alexandria, Virginia
Conditions
Osteoarthritis
Interventions
Uniglide Mobile Bearing Unicondylar Knee System, Uniglide Fixed Bearing Unicondylar Knee System
Device
Lead sponsor
Corin
Industry
Eligibility
40 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
6
States / cities
La Quinta, California • Clearwater, Florida • Lexington, Kentucky + 3 more
Conditions
Revision, Joint
Interventions
Trabecular Metal Revision Cup, Trabecular Metal Modular Cup
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Osteoarthritis, Knee
Interventions
active tDCS paired with active MBM, sham tDCS paired with sham MBM
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Conditions
Anesthesia, Local
Interventions
liposomal bupivacaine/plain bupivacaine peri-articular injection
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Low-Dose Bupivacaine, Mepivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Days and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Conditions
Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
Interventions
Nexel Total Elbow
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2036
U.S. locations
4
States / cities
Golden, Colorado • Charlotte, North Carolina • Philadelphia, Pennsylvania + 1 more
Conditions
Physical Therapy, Total Joint Arthroplasty, Same-day Discharge
Interventions
Novel same-day discharge protocol after total joint arthroplasty, Conventional postoperative physical therapy clearance
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 90 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland • New York, New York
Terminated Not applicable Interventional Results available

Trident II Revision Outcomes Study

NCT04317586
Conditions
Arthroplasty, Hip Revision
Interventions
Trident II Tritanium Acetabular Shell for Revision
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years to 85 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
10
States / cities
Lafayette, Louisiana • New Orleans, Louisiana • Boston, Massachusetts + 7 more
Recruiting No phase listed Observational

Testosterone Levels and Cutibacterium

NCT05030220
Conditions
Arthroplasty, Replacement, Shoulder
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 89 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Seattle, Washington