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ClinicalTrials.gov public records Last synced Oct 25, 2026, 7:58 AM EDT

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Showing 145–168 of 180 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: B12 Clear all
Completed Phase 3 Interventional

Trial of Vitamins in HIV Progression and Transmission

NCT00197743
View directory record Official record
Conditions
HIV Infections, Disease Transmission, Vertical
Interventions
Vitamin A + Beta Carotene, Multivitamins, Placebo
Dietary Supplement · Other
Lead sponsor
Harvard School of Public Health (HSPH)
Other
Eligibility
18 Years and older · Female only
Enrollment
1,085 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 11, 2010 · Synced Oct 25, 2026, 7:58 AM EDT
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers

Combination Gerotherapeutic Interventions for Healthspan Improvement

NCT07475546
View directory record Official record
Conditions
Healthspan Improvement, Aging, Longevity
Interventions
Rapamycin, Naltrexone, Metformin, NAD+, GSH, Infinite Supplement, Placebo/control, B12, Intervention: Guided Meditation Program, Control: Podcast Listening Activity, Control: Standard Exercise Regimen, Intervention: Structured Exercise Program
Drug · Dietary Supplement · Behavioral
Lead sponsor
AgelessRx
Industry
Eligibility
60 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 25, 2026, 7:58 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)

NCT01370954
View directory record Official record
Conditions
Early Memory Loss, Mild Cognitive Impairment, Alzheimer's Disease, Vascular Dementia
Interventions
CerefolinNAC®
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
50 Years to 80 Years
Enrollment
204 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Hickory, North Carolina
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 1 Interventional

Open Label Study: Treatment of ALS Fatigue With PolyMVA

NCT04557410
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
PolyMVA
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Oct 25, 2026, 7:58 AM EDT
Completed No phase listed Observational

Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements

NCT01745198
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Related Disorders
Interventions
Not listed
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 3 Interventional Results available

Randomised Study of Interferon-free Treatment for Recently Acquired Hepatitis C in PWID and People With HIV Coinfection.

NCT02625909
View directory record Official record
Conditions
Hepatitis C
Interventions
SOF/VEL for 6 weeks, SOF/VEL for 12 weeks
Drug
Lead sponsor
Kirby Institute
Government
Eligibility
18 Years and older
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Nutraceutical in Raising Circulating Serum Vitamin, Mineral and Amino Acid Levels in Patients.

NCT04054505
View directory record Official record
Conditions
Vitamin Deficiency
Interventions
EZPAK, Placebo
Dietary Supplement
Lead sponsor
Optimal Health Research
Other
Eligibility
26 Years to 75 Years
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 3 Interventional

Vitamin Therapy for Prevention of Stroke

NCT00004734
View directory record Official record
Conditions
Stroke, Cerebral Infarction, Myocardial Infarction
Interventions
pyridoxine, cyanocobalamin, folic acid multivitamin
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
35 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2004
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 2Phase 3 Interventional

Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism

NCT00273650
View directory record Official record
Conditions
Autistic Disorder
Interventions
methylcobalamin, saline placebo
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
3 Years to 8 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 2 Interventional Results available

Alii Supplement Study

NCT07271316
View directory record Official record
Conditions
Nutrient Deficiency, Happiness, Digestive Health, Vulnerability to Disease, Mood Swings, Energy
Interventions
Alii Supplement
Dietary Supplement
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 1 Interventional Results available

Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

NCT03661541
View directory record Official record
Conditions
HSV, Herpes Labialis
Interventions
Squaric Acid Dibutyl Ester
Drug
Lead sponsor
Squarex, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Oct 25, 2026, 7:58 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Clinical and Laboratory Study of Methylmalonic Acidemia

NCT00078078
View directory record Official record
Conditions
Organic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism
Interventions
Not listed
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
1 Month to 115 Years
Enrollment
2,275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2004
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 2 Interventional

Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)

NCT00054938
View directory record Official record
Conditions
Systemic Lupus Erythematosus, Lupus
Interventions
pravastatin, aspirin, ramipril, Vitamins: B6, B12, and folate, heart health educational program
Drug · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 24, 2013 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 4 Interventional Results available

Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients

NCT04054999
View directory record Official record
Conditions
Vasoplegic Syndrome, Liver Transplant; Complications
Interventions
Hydroxocobalamin, Methylene Blue
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Oct 25, 2026, 7:58 AM EDT
Terminated Phase 2Phase 3 Interventional

Vitamin B12 Status and Response to Vitamin B12 Supplementation in Patients With Parkinson's Disease

NCT00208611
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Vitamin B12 Supplementation
Dietary Supplement
Lead sponsor
Emory University
Other
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Nitric Oxide Supplementation Product on Endothelial Dysfunction and Prehypertensive Adults

NCT03895749
View directory record Official record
Conditions
Hypertension
Interventions
NEO40 Daily
Dietary Supplement
Lead sponsor
Hypertension Institute, Nashville
Other
Eligibility
18 Years to 75 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Oct 25, 2026, 7:58 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Absorption of Transdermal Vitamins in Post Bariatric Surgery Patients

NCT03360435
View directory record Official record
Conditions
Bariatric Surgery Candidate, Vitamin Deficiency, Mineral Deficiency
Interventions
Patch MD MultiVitamin Plus patch
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 9, 2021 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a B12 Vitamin to Increase Energy and Focus

NCT05517005
View directory record Official record
Conditions
B12 Deficiency Vitamin, Energy Supply; Deficiency, Mood
Interventions
Hype Bites Supplement
Dietary Supplement
Lead sponsor
Sourse
Industry
Eligibility
24 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 2 Interventional Results available

Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment

NCT00606502
View directory record Official record
Conditions
Non-small Cell Lung Cancer
Interventions
Pralatrexate, Erlotinib, Vitamin B12, Folic Acid
Drug · Dietary Supplement
Lead sponsor
Spectrum Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
15
States / cities
Bakersfield, California • San Diego, California • Port Saint Lucie, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2021 · Synced Oct 25, 2026, 7:58 AM EDT
Terminated Phase 2 Interventional Results available

Pemetrexed &Oxaliplatin in Patients w Recurrent NSCLCa After Failure to Platinum Based Adjuvant Chem

NCT00612677
View directory record Official record
Conditions
Lung Cancer
Interventions
Oxaliplatin, Pemetrexed
Drug
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

BVAIT: B-Vitamin Atherosclerosis Intervention Trial

NCT00114400
View directory record Official record
Conditions
Atherosclerosis
Interventions
folic acid, vitamin B12, vitamin B6
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
40 Years and older
Enrollment
506 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2009 · Synced Oct 25, 2026, 7:58 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)

NCT01369030
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Deplin®
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
554 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Greensboro, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 25, 2026, 7:58 AM EDT
Completed Not applicable Interventional

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

NCT00004495
View directory record Official record
Conditions
End Stage Renal Disease, Hyperhomocysteinemia
Interventions
cyanocobalamin, folic acid, pyridoxine
Drug
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 89 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2000
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Oct 25, 2026, 7:58 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Lactoferrin-enriched Whey on Iron Status in Females

NCT06232642
View directory record Official record
Conditions
Serum Ferritin
Interventions
Lactoferrin, iron and B12 in Whey Protein, Lactoferrin, Iron and B12 in Rice Protein, Lactoferrin, Iron and B12 in Maltrodextrin
Dietary Supplement
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 25, 2026, 7:58 AM EDT