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Conditions: HIV Infections, Syphilis Infection
Interventions: Chembio HIV/Syphilis rapid Point of Care (POC) test, Laboratory-based HIV and syphilis testing; Diagnostic Test
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 14 Years to 45 Years · Female only
Enrollment: 1,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Oxygen Saturation
Interventions: Baseline hypoxic test, Finger hyperperfusion via adenosine, Finger hypoperfusion via by norepinephrine; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Cardiometabolic Health, Health Behavior, Overweight/Obesity, Puberty
Interventions: Family-Based Treatment (FBT); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 6 Years to 8 Years · Female only
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Atrial Fibrillation, Stroke
Interventions: Alert-based computerized decision support; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Edgewood, Kentucky • Boston, Massachusetts

Conditions: Past-3-month Non-medical Use of Prescription Opioids, Social Media Users, Without Substance Use Disorders, Young Adults
Interventions: Theory-based and peer-led intervention on Instagram; Behavioral
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 25 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Glioblastoma
Interventions: pH MRI based resection of GBM; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Repetitive Negative Thinking, Serious Mental Illness Symptoms
Interventions: Active mindfulness-based neurofeedback (Active mbNF), Mindfulness Training, Sham mindfulness-based neurofeedback; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 21 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Implantable Defibrillator, Pacemaker
Interventions: Alert-based care, Guideline-based Care; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Failure
Interventions: Remote Patient Monitoring, Remote Self-Care Education, Video Based Visits; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Patient Communication
Interventions: educational LLM-based feedback tool; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Use Disorder
Interventions: Large language model-based chatbot brief alcohol intervention session; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 29 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Binge Eating, Binge Eating Behaviour, Binge Eating/Loss of Control Eating, Body Image, Body Image Disturbance
Interventions: Assessment-only, Minimal-Assessment Control, values-based reflection and goal-setting/action-planning exercises; Behavioral
Lead sponsor: Taylor Rezeppa; Other
Eligibility: 18 Years and older · Female only
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Athens, Ohio

Conditions: E Cig Use, Prescription Drug Misuse, Vaping
Interventions: School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse; Behavioral
Lead sponsor: Christopher Williams; Industry
Eligibility: 7 Years to 11 Years
Enrollment: 3,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Tobacco Use Disorder/Cigarette Smoking
Interventions: Multi-Theory Model (MTM)-Based Smoking Cessation Program; Behavioral
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years to 29 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Knee Osteoarthritis
Interventions: Clinician-administered joint mobilization, Exercise-based physical therapy, Self-administered joint mobilization; Other
Lead sponsor: Texas Woman's University; Other
Eligibility: 45 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Allen, Texas • Plano, Texas

Conditions: Crisis; Emotional, Suicidal Ideas, Suicidal Ideation, Suicidal Impulses, Suicidal and Self-injurious Behaviour, Suicide Attempts
Interventions: Couples-based Crisis Response Planning, Crisis Response Planning; Behavioral
Lead sponsor: University of Georgia; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Mental Health Issue, Sleep Disorder
Interventions: Ear Plugs, Eye Mask, In person safety check, Scented Oil, Video based safety check; Device · Behavioral · Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 90 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Autism, Autism Spectrum Disorder
Interventions: Charades based mobile digital therapeutic; Device
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Shoulder Injuries, Shoulder Pain
Interventions: CRISP: Criteria-Based Approach for the Rehabilitation for Non-Operative Shoulder Injuries, Standard of Care; Other
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Chronic Stroke
Interventions: Active Comparator: Control, Virtual reality based dance group; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 45 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: BMI, Blood Cholesterol, Blood Pressure Monitoring, Diabetes (DM), Diabetes Education, Weight Change
Interventions: Remote Patient Monitoring in a Faith-Based Program, Traditional Cohort Faith-based DSMES program; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Prostate Cancer
Interventions: General Nutritional Counseling, Whole-food, Plant-Based Diet; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 45 Years to 99 Years · Male only
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 3
States / cities: Baltimore, Maryland • New York, New York

Conditions: Complex Medical Patients, Opioid Dependence, Primary Care Patients With Chronic Conditions, Substance Abuse Disorders
Interventions: MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing); Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: HIV-1-infection
Interventions: BIC/LEN FDC, Bictegravir, Lenacapavir, Stable Baseline Regimen; Drug
Lead sponsor: Gilead Sciences; Industry
Eligibility: 18 Years and older
Enrollment: 689 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 40
States / cities: Berkeley, California • Beverly Hills, California • Los Angeles, California + 34 more

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Implementation of an Opt-Out Testing and Rapid Diagnostic Strategy for Syphilis and HIV in Pregnant Patients Presenting to the Emergency Department

Hand Perfusion and Pulse Oximetry Performance

Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks

Computerized Decision Support to Prevent Stroke in Atrial Fibrillation

Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults

Phase I Trial of pH Resections of GBM at VA

Mindfulness-based Neurofeedback to Reduce Negative Thinking in CHARMS Adolescents

Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices: The RAPTOR-CIED Study (Main Phase)

Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants

Clinical Language Evaluation With AI for Residents

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

Testing SHAPE: A Single-Session Intervention Targeting Binge Eating in Women Through Assessment and Values-Based Strategies

A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach

Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial

Short-term and Intermediate-term Effects of Self-applied Joint Mobilization Versus Clinician-applied Joint Mobilization in Addition to Exercise in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

Couple-Based Crisis Safety Planning

Improving Sleep in a Psychiatric Hospital

Evaluating Efficacy of a Digital Game Therapeutic for Children With Autism

Efficacy of a Criteria Based Clinical Pathway for Rehabilitation of Shoulder Injuries

Active Balance and Cardio Care Intervention on Physical and Cardiovascular Health in People With Chronic Stroke

Empowering Faith-based Communities to Provide Personalized Diabetes Self-management Education and Support (DSMES) in the Magic City

Whole-Food Plant-Based Diet to Control Weight and MetaboInflammation in Overweight/Obese Men With Prostate Cancer

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (ARTISTRY-1)