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ClinicalTrials.gov public records Last synced Oct 17, 2026, 5:46 AM EDT

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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: BFR Clear all
Withdrawn Not applicable Interventional

The Effect of Low-Intensity Blood Flow Restriction Therapy on the Management of Acute Ankle Sprains

NCT05596162
View directory record Official record
Conditions
Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree, Musculoskeletal Injury
Interventions
Blood Flow Restriction Therapy, Standard Physical Therapy
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Low-Intensity Blood Flow Restriction Training as a Pre-Operative Rehabilitative Modality to Improve Post-Operative Outcomes for ACL Reconstruction

NCT04302558
View directory record Official record
Conditions
ACL Injury
Interventions
Exercise Blood Flow Restriction training, SHAM Exercise Blood Flow Restriction training
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft

NCT04519801
View directory record Official record
Conditions
ACL Injury
Interventions
Blood Flow Restriction (BFR) therapy, Standard REHAB
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
15 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

BFRT MPFL and ACL Reconstruction Rehab

NCT05426954
View directory record Official record
Conditions
Medial Patellar Femoral Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation utilizing blood flow restrictive therapy
Other
Lead sponsor
Richard Watson, PT
Other
Eligibility
13 Years to 40 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 17, 2024 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Blood Flow Restriction Exercise Study

NCT02868021
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Strength testing, Short Physical Performance Battery (SPPB), Six-minute walk (SMW), Numerical pain scale, Self-assessed function, Muscle biopsies, Determination of 1 Repetition Maximum (1-RM), Blood flow restriction exercise, Borg CR10 scale
Device · Behavioral · Procedure
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 17, 2026, 5:46 AM EDT
Enrolling by invitation Not applicable Interventional

Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI

NCT07678437
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Blood flow-restricted exercise
Behavioral
Lead sponsor
Quality Living, Inc.
Other
Eligibility
19 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Blood Flow Restriction Training for The Shoulder

NCT04540367
View directory record Official record
Conditions
Healthy
Interventions
Blood flow restriction therapy
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 17, 2026, 5:46 AM EDT
Enrolling by invitation No phase listed Observational

Blood Flow Restriction Following ACLR w/Quad Autograft

NCT06636045
View directory record Official record
Conditions
Autografts, Blood Flow Restriction Therapy, Rehabilitation Outcome, Quadriceps Muscle Strength, Anterior Cruciate Ligament Reconstruction
Interventions
Not applicable- observational study
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
14 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 17, 2026, 5:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs

NCT06276673
View directory record Official record
Conditions
Blood Vessel Disease, Muscle Edema
Interventions
Delfi
Device
Lead sponsor
Salisbury University
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2024 · Synced Oct 17, 2026, 5:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors

NCT07460609
View directory record Official record
Conditions
Healthy Ageing
Interventions
Blood Flow Restriction Training Exercise, Health Education
Behavioral
Lead sponsor
Baylor University
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

NCT05754632
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Knee Injuries, Quadriceps Muscle Atrophy
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty

NCT04086615
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
NMES and exercise supplemented with high BFR, NMES and exercise supplemented with low BFR
Device
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 44 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Fort Campbell North, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 17, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

Evaluating the Efficacy of Blood Flow Restriction Therapy in a Randomized Clinical Trial for Postoperative Rehabilitation Following Ankle Ligament Reconstruction

NCT07451210
View directory record Official record
Conditions
Ankle Reconstruction, Blood Flow Restriction Therapy, Physical Therapy
Interventions
blood flow restriction
Device
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
5
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Two Time a Week vs. Five Time a Week Blood Flow Restriction Training Program for the Lower Extremity.

NCT05342909
View directory record Official record
Conditions
Blood Flow Restriction Training
Interventions
5x a week BFR training group, 2x a week BFR training group
Other
Lead sponsor
George Fox University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Newberg, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 17, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

Blood Flow Restriction for Optimizing Balance in Parkinson's Disease

NCT06508801
View directory record Official record
Conditions
Parkinson's Disease and Parkinsonism
Interventions
Blood flow restriction training, Instability Resistance Training
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
40 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Use of Blood Flow Restriction (BFR) Therapy in Post-operative Rehabilitation Following Distal Biceps Tendon Repair

NCT04503421
View directory record Official record
Conditions
Bicep Tendon Rupture
Interventions
Blood Flow Restriction Therapy
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2023 · Synced Oct 17, 2026, 5:46 AM EDT
Withdrawn Not applicable Interventional

BFR Therapy After ACL Reconstruction

NCT03794570
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 17, 2026, 5:46 AM EDT
Terminated Not applicable Interventional

Efficacy of BFR Training Combined With Eccentric Exercise as Assessed by SWE in Subjects With Chronic AT

NCT03264326
View directory record Official record
Conditions
Achilles Tendinopathy
Interventions
Blood Flow Restriction Training, Sham Blood Flow Restriction Training, Eccentric Exercise
Other
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lower Extremity BFR-randomized Controlled Trial Healthy Volunteers

NCT05868304
View directory record Official record
Conditions
Healthy
Interventions
BFR, Stanard strengthening program.
Device · Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 17, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)

NCT06664827
View directory record Official record
Conditions
Healthy, Healthy Male and Female Subjects, Healthy Volunteers
Interventions
Delfi PTS Blood Flow Restriction Tourniquet System
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2025 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Blood Flow Restriction Following ACL Reconstruction

NCT03758755
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
13 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 17, 2026, 5:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Contralateral Blood Flow Resistance Improves Scapular Muscle Activation During Pickleball Forehand Swings

NCT07728838
View directory record Official record
Conditions
Shoulder and Upper Arm Injury
Interventions
Not listed
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 30 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 17, 2026, 5:46 AM EDT
Completed Not applicable Interventional

The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery

NCT03035266
View directory record Official record
Conditions
Knee Injuries
Interventions
Blood Flow Restriction, Standard rehabilitation
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
West Point, New York • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2020 · Synced Oct 17, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pneumatic Compression vs Blood Flow Restriction for Muscle Recovery

NCT06815367
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Pneumatic Compression, Blood Flow Restriction
Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 17, 2026, 5:46 AM EDT