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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Behavioral Couples Therapy Clear all
Enrolling by invitation Phase 2 Interventional

Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk

NCT06649929
View directory record Official record
Conditions
Sleep Apnea, Sleep Disturbance
Interventions
Couples-based treatment- Patient, Couples-based treatment- Partner, Information control- Patient, Information control- Partner
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
35 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Tuscon, Arizona • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Behavioral Couples Therapy for Female Drug-Abusing Patients

NCT01189305
View directory record Official record
Conditions
Drug Abuse
Interventions
Behavioral Couples Therapy, Individual Drug Counseling
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2015 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Phase 3 Interventional

Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder

NCT02336971
View directory record Official record
Conditions
PTSD, Marital Relationship
Interventions
CBCT for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
Toronto Metropolitan University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 11, 2026, 10:10 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Brain-to-brain Synchrony in Ss With Different Levels of Social Interaction

NCT06673589
View directory record Official record
Conditions
Social Dynamics
Interventions
Transcendental Meditation
Behavioral
Lead sponsor
Maharishi International University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Fairfield, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Coping Together After Breast Cancer

NCT03930797
View directory record Official record
Conditions
Breast Cancer
Interventions
Intimacy Enhancement, Living Healthy Together
Behavioral
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional

Intensive Weekend Retreat Multi-Couple Group Therapy for PTSD

NCT03158558
View directory record Official record
Conditions
PTSD
Interventions
Accelerated, Multi-Couple Group CBCT for PTSD
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Killeen, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automated & Coached Web-based Programs to Improve and Strengthen Romantic Relationships

NCT03568565
View directory record Official record
Conditions
Relationship, Marital
Interventions
ePREP Program, OurRelationship Program
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 64 Years
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 13, 2020 · Synced Sep 11, 2026, 10:10 AM EDT
Recruiting Not applicable Interventional

A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers

NCT06172907
View directory record Official record
Conditions
Cancer, Survivorship, Caregiver Burden, Psychological Distress, Coping Skills, Couples
Interventions
Young Adults Coping with Cancer Together Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • Concord, Massachusetts • Danvers, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional

UCAN: Uniting Couples in the Treatment of Anorexia Nervosa

NCT00928109
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
CBCT, Family Supportive Therapy
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 8, 2012 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using A Couple-focused Web-based Tailored Symptom Self-management Program

NCT04350788
View directory record Official record
Conditions
Prostate Cancer
Interventions
Survivorship Care Plan, Enhanced Survivorship Care Plan
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 11, 2026, 10:10 AM EDT
Not listed Not applicable Interventional

Couples Coping With Alzheimer's Disease

NCT00438724
View directory record Official record
Conditions
Aging, Alzheimer Disease, Dementia
Interventions
Information, counseling and support
Behavioral
Lead sponsor
Alzheimer's Association
Other
Eligibility
21 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2007 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Strength at Home Couples Program (PTSD-Focused Relationship Enhancement Therapy for Returning Veterans)

NCT00827879
View directory record Official record
Conditions
Aggression, Post Traumatic Stress Disorders
Interventions
Strength at Home Couples Group, Supportive Group Therapy
Behavioral
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Sep 11, 2026, 10:10 AM EDT
Recruiting Not applicable Interventional

A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

NCT06990191
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Partnered Prolonged Exposure (PPE), Prolonged Exposure (PE)
Behavioral
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Phoenix, Arizona • San Diego, California • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Phase 1Phase 2 Interventional

Fathers for Change for Men With Co-occurring Domestic Violence and Substance Abuse

NCT01385553
View directory record Official record
Conditions
Domestic Violence, Substance Abuse, Parenting
Interventions
Fathers for Change, Individual Drug Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of a Couple-Focused mHealth Symptom Self-management Program

NCT03489057
View directory record Official record
Conditions
Prostate Cancer
Interventions
Prostate Cancer Education and Resources for Couples (PERC), usual care plus NCI website
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
40 Years to 75 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 11, 2026, 10:10 AM EDT
Recruiting Not applicable Interventional

The Improving Sleep in African American Couples Study (ISAAC)

NCT07447284
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
CPAP Training and Education, Virtual Disease Support Group Sessions, Couple CPAP Training and Education, Couples Virtual OSA Support Group Sessions, CPAP Tele-monitoring and Feedback, Couples' Cognitive Behavioral Therapy
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
30 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Cleveland, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Active, not recruiting Not applicable Interventional

Relationship Checkups to Reduce Veteran Suicide Risk

NCT05525676
View directory record Official record
Conditions
Relationship Distress, Mental Health
Interventions
Brief Relationship Checkup (BRC), Co-Located Collaborative Care (CCC)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Cognitive-Behavioral Conjoint Therapy (CBCT) Project

NCT02720016
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
CBCT-Home Based (CBCT-HB), CBCT-Office Based (CBCT-OB), PTSD Family Education (PFE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2022 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional

Family-Based Treatment for Parental Substance Abuse and Child Maltreatment

NCT01656837
View directory record Official record
Conditions
Substance Abuse, Child Abuse, Child Neglect
Interventions
Comprehensive Community Treatment, MST-BSF
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Phase 2Phase 3 Interventional

Effectiveness of Cognitive Behavioral Couples Therapy for Post-traumatic Stress Disorder

NCT00669981
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
Cognitive behavioral couples therapy for post-traumatic stress disorder (CBCT for PTSD)
Behavioral
Lead sponsor
Toronto Metropolitan University
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 25, 2013 · Synced Sep 11, 2026, 10:10 AM EDT
Recruiting Phase 2 Interventional

Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD

NCT06194851
View directory record Official record
Conditions
Post-Traumatic Stress Disorder (PTSD)
Interventions
Oxytocin nasal spray, Saline nasal spray, Brief Cognitive-Behavioral Conjoint Therapy
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional

Partner-Assisted Emotional Disclosure for GI Cancer

NCT00734513
View directory record Official record
Conditions
Cancer of the GI System-stages II III and IV
Interventions
Partner-assisted emotional disclosure, Cancer Education
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Effectiveness of Behavioral Text Messages to Promote Attendance at HMRE Sessions

NCT02787460
View directory record Official record
Conditions
Family Relations, Marriage
Interventions
Behavioral Text Messages
Behavioral
Lead sponsor
Mathematica Policy Research, Inc.
Other
Eligibility
Not listed
Enrollment
1,904 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 11, 2026, 10:10 AM EDT
Completed Not applicable Interventional Results available

Improving Veteran Adherence to Treatment for PTSD Through Partnering With Families

NCT03256227
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Family Supported Prolonged Exposure, Standard Prolonged Exposure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
Decatur, Georgia • Ann Arbor, Michigan • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 11, 2026, 10:10 AM EDT