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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Beta-hydroxy beta-methylbutyrate Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Time-Restricted Feeding Plus Resistance Training in Active Females

NCT03404271
View directory record Official record
Conditions
Healthy Active Females
Interventions
Beta-hydroxy beta-methylbutyrate, Resistance Training, Protein Supplementation, Time-Restricted Feeding
Dietary Supplement · Other · Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional

Efficacy of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation in Hemodialysis Patients

NCT01837238
View directory record Official record
Conditions
Complication of Dialysis, Chronic Kidney Disease, Muscle Loss, End Stage Renal Disease
Interventions
HMB, placebo
Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
30 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 30, 2016 · Synced Sep 16, 2026, 6:43 PM EDT
Withdrawn Not applicable Interventional

Improving Muscle Function in Nutritionally at Risk, Elderly Patients

NCT03071354
View directory record Official record
Conditions
Muscle Weakness, ICU-acquired Weakness
Interventions
HMB protein supplement (3g), Nutritional Supplement
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Sep 16, 2026, 6:43 PM EDT
Recruiting Phase 2 Interventional

Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes

NCT05869812
View directory record Official record
Conditions
Atrophy
Interventions
CaHMB (Dietary supplement, not Drug), CaLa
Drug · Dietary Supplement
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training

NCT01941368
View directory record Official record
Conditions
Exercise
Interventions
Placebo, HMB-FA, High Intensity Interval Training
Dietary Supplement · Procedure
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 16, 2014 · Synced Sep 16, 2026, 6:43 PM EDT
Not yet recruiting Phase 2 Interventional

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

NCT07760948
View directory record Official record
Conditions
Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss, Older Adults
Interventions
Calcium-HMB Plus Vitamin D3, Matching placebo
Dietary Supplement · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 16, 2026, 6:43 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism

NCT02717013
View directory record Official record
Conditions
Obesity
Interventions
Placebo, HMB
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of HMB Supplementation on Recovery Following ACL Surgery

NCT02602561
View directory record Official record
Conditions
ACL Injury
Interventions
HMB, Placebo
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 16, 2026, 6:43 PM EDT
Not yet recruiting Not applicable Interventional

Safety and Tolerability of a Nutritional Formula Designed to Aid in Maintenance of Muscle During Periods of Caloric Restriction in Adults

NCT07447843
View directory record Official record
Conditions
Obesity & Overweight
Interventions
Redefine, Placebo
Dietary Supplement
Lead sponsor
Nature's Sunshine Products, Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Lehi, Utah
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alternate Dosing Strategies for Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation: Effect on Plasma HMB Responses

NCT01914952
View directory record Official record
Conditions
Focus of the Study is to Examine Plasma HMB Levels After Oral HMB Supplementation
Interventions
CaHMB capsule, HMB free acid gelcap, HMB free acid mixed in water, CaHMB in water, HMB free acid
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 30 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 15, 2014 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Pre-exercise Beta-hydroxy-beta-methylbutyrate Free Acid (HMB-FA) and Cold Water Therapy for the Attenuation of Muscle Damage and Soreness

NCT01793779
View directory record Official record
Conditions
Muscle Damage
Interventions
cold water immersion, beta-hydroxy-beta-methylbutyrate free acid (HMB-FA), Placebo
Procedure · Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 31, 2013 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nutritional Intervention for Age-related Muscular Function and Strength Losses

NCT00874575
View directory record Official record
Conditions
Muscle Strength, Sarcopenia
Interventions
Placebo, Vitamin D, Beta-hydroxy-Beta-methylbutyrate, Beta-hydroxy-Beta-methylbutyrate and Vitamin D
Dietary Supplement · Drug
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
60 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Ames, Iowa • Brookings, South Dakota
Source: ClinicalTrials.gov public record
Updated Sep 16, 2014 · Synced Sep 16, 2026, 6:43 PM EDT
Recruiting Not applicable Interventional

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

NCT05166499
View directory record Official record
Conditions
Cirrhosis, Liver
Interventions
Hydroxy Methyl Butyrate, Balanced Amino Acids
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2

NCT02043171
View directory record Official record
Conditions
Sarcopenia
Interventions
Placebo, HMB plus Vitamin D, Non-Exercise, Exercise
Dietary Supplement · Drug · Behavioral
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
60 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Efficacy of a New Delivery System for Beta-hydroxy-beta-methylbutyrate

NCT01150526
View directory record Official record
Conditions
Healthy
Interventions
CaHMB, HMB Free Acid Gel, Placebo, Placebo Gel Dosage
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 17, 2012 · Synced Sep 16, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of HMB, ATP, and HMB Plus ATP on Muscle Mass, Strength, and Power in Resistance Trained Athletes

NCT01508338
View directory record Official record
Conditions
Healthy Experienced Weight Training Males
Interventions
Placebo, HMB, Peak ATP and HMB, ATP
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 30 Years · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Sep 16, 2026, 6:43 PM EDT