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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Biofinity Clear all
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens

NCT03920280
View directory record Official record
Conditions
Refractive Errors
Interventions
LID015385 contact lenses, Comfilcon A soft contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
8
States / cities
Maitland, Florida • Orlando, Florida • Pensacola, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2022 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Comparison of Clinical Performance of Two Monthly Replacement Toric Soft Contact Lenses

NCT06165627
View directory record Official record
Conditions
Ametropia, Astigmatism
Interventions
Lehfilcon A toric contact lenses, Comfilcon A toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 45 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
5
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 2 more
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Pilot Clinical Performance of a Silicone Hydrogel Lens for Up to Six Nights of Extended Wear

NCT04403542
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
Lehfilcon A contact lens, Comfilcon A contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
3
States / cities
Medina, Minnesota • Granville, Ohio • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Validation of Biofinity Toric MTO (Made To Order) Lenses

NCT02185105
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
comfilcon A MTO, comfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Validation Study of Comfilcon A Multifocal Toric Contact Lenses

NCT03417557
View directory record Official record
Conditions
Presbyopia
Interventions
Comfilcon A lens (test), Omafilcon B lens (control)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Wear Experience With Daily Contact Lenses

NCT05096156
View directory record Official record
Conditions
Contact Lens
Interventions
Precision1® Daily Disposable Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Silicone Hydrogel Contact Lens Following One Night of Extended Wear

NCT03560141
View directory record Official record
Conditions
Refractive Errors
Interventions
LID011121 contact lens, Comfilcon A contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens

NCT04055519
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, Multi-purpose disinfection solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
3
States / cities
Maitland, Florida • Bloomington, Illinois • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a Daily Wear Monthly Replacement Silicone Hydrogel Toric Contact Lens

NCT05211739
View directory record Official record
Conditions
Refractive Errors, Astigmatism
Interventions
Lehfilcon A toric contact lenses, Comfilcon A toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
7
States / cities
Longwood, Florida • Maitland, Florida • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of Two Monthly Contact Lenses

NCT03459131
View directory record Official record
Conditions
Refractive Errors
Interventions
Comfilcon A with Digital Zone Optics™ contact lenses, Comfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 35 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2019 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Bifocal Lenses In Nearsighted Kids

NCT02255474
View directory record Official record
Conditions
Refractive Errors
Interventions
Biofinity Multifocal D +1.50 add, Biofinity Multifocal D +2.50 add, Biofinity
Device
Lead sponsor
Ohio State University
Other
Eligibility
7 Years to 11 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
Columbus, Ohio • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of Two Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lenses

NCT04980456
View directory record Official record
Conditions
Myopia
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
14
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Johnson & Johnson Vision Care Investigational Contact Lens Compared to a Marketed Monthly Replacement Contact Lens

NCT02515994
View directory record Official record
Conditions
Refractive Error
Interventions
senofilcon C, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
10
States / cities
Jacksonville, Florida • Longwood, Florida • Bloomington, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens

NCT04476784
View directory record Official record
Conditions
Myopia
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
5
States / cities
Maitland, Florida • Bloomington, Illinois • Pittsburg, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Multicenter Dispensing Study of Biofinity Toric Made-To-Order Lenses in Extended Power Ranges

NCT02193178
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
comfilcon A Toric
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Bloomington, Indiana • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 2, 2026, 10:11 PM EDT
Completed No phase listed Observational

Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses

NCT05886894
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B multifocal soft contact lenses, Comfilcon A multifocal soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
San Diego, California • Jacksonville, Florida • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Dispensing Evaluation of a Galyfilcon A Prototype Lens and a Marketed Contact Lens

NCT01180985
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
4
States / cities
Jacksonville, Florida • Orlando, Florida • Fincastle, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Comfilcon A and Senofilcon A Lenses

NCT01695369
View directory record Official record
Conditions
Myopia
Interventions
Senofilcon A; Comfilcon A, Comfilcon A; Senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a HYDRAGLYDE® Regimen

NCT03026257
View directory record Official record
Conditions
Refractive Errors, Myopia, Hypermetropia
Interventions
Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent, Hydrogen peroxide-based contact lens solution with added wetting agent, Senofilcon C contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Habitual Multi-Purpose Solution (HMPS)
Device
Lead sponsor
Alcon, a Novartis Company
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Birmingham, Alabama • Cleveland, Ohio • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Sep 2, 2026, 10:11 PM EDT
Completed No phase listed Observational

Air Optix Daily Wear Contact Lenses

NCT05827224
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive, Comfilcon A spherical soft contact lenses, Comfilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Timeline
2023 – 2024
U.S. locations
5
States / cities
Orlando, Florida • Medina, Minnesota • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

NCT03586167
View directory record Official record
Conditions
Refractive Errors
Interventions
LID014341 contact lenses, Comfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Maitland, Florida • Johns Creek, Georgia • Bloomington, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Monthly Replacement Silicone Hydrogel Lens

NCT04178720
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
8
States / cities
Longwood, Florida • Maitland, Florida • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2021 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Silicone Hydrogel Lens

NCT04207749
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
LID015385 contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
18
States / cities
Glendale, Arizona • Brentwood, California • Irvine, California + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Sep 2, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Accommodative Behaviors in Multifocal Contact Lenses

NCT06064617
View directory record Official record
Conditions
Accommodation Disorder
Interventions
Center-Near (+2.50D) Coopervision Biofinity Multifocal Contact Lens, Center Distance (+2.50 D) Coopervision Biofinity Multifocal Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 2, 2026, 10:11 PM EDT