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Conditions: Binge Eating
Interventions: Go/No-Training, Stop-Signal Training, Dot-Probe Paradigm, Generic Response Training; Behavioral
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio; Diagnostic Test
Lead sponsor: Temple University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: HER2-positive Breast Cancer, Metastatic Cancer, Metastatic Breast Cancer, Metastatic, HER2-positive Metastatic Breast Cancer, HER2 Mutation-Related Tumors, HER-2 Protein Overexpression, HER2-negative Breast Cancer, Triple Negative Breast Cancer, HR Positive, Hormone Receptor-positive Breast Cancer, Estrogen Receptor Positive Tumor, Progesterone Receptor-positive Breast Cancer, Hormone Receptor Negative Breast Carcinoma, Solid Tumor, Solid Tumor, Adult, Solid Carcinoma, HER2 Low Breast Cancer, HER2 Low Breast Carcinoma, ER Positive Breast Cancer, PR-positive Breast Cancer, Minimal Residual Disease, Colo-rectal Cancer, Colon Cancer, Rectal Cancer, ctDNA Monitoring, Colorectal Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Neoplasm, Residual, Adenocarcinoma of Colon, Adenocarcinoma
Interventions: ALX148, Fam-Trastuzumab Deruxtecan-Nxki, Zanidatamab, Tucatinib, TTX-MC138; Drug
Lead sponsor: QuantumLeap Healthcare Collaborative; Other
Eligibility: 18 Years and older
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2031
U.S. locations: 10
States / cities: Birmingham, Alabama • Phoenix, Arizona • Aurora, Colorado + 7 more

Conditions: Working Memory, Emotions
Interventions: Working Memory Task, Reward Learning Task, Facial Emotion Recognition Task; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 80 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Videofluoroscopic Swallowing Study (VFSS), Voluntary Peak Cough Flow Testing, Iowa Oral Performance Instrument, Capsaicin Challenge, Pulmonary Function Testing, Eating Assessment Tool 10, The Center for Neurologic Study Bulbar Function Scale; Procedure · Device · Drug + 1 more
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 2
States / cities: Gainesville, Florida • Tampa, Florida

Conditions: Parkinson's Disease (PD), Essential Tremor
Interventions: Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus, Multisyllabic sequence learning; Behavioral · Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Stroke
Interventions: Oculus Rift headset, Exoskeleton Device; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Amblyopia
Interventions: Donepezil, Single-letter training, Uncrowd training; Drug · Behavioral
Lead sponsor: Dennis Levi; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Cognitive Pain Control
Interventions: Attention/Distraction Strategy, Stimulus Quality/Severity Strategy, Control Strategy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Speech Sound Disorder
Interventions: Speech Motor Chaining; Behavioral
Lead sponsor: Syracuse University; Other
Eligibility: 9 Years to 17 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Diabetic Peripheral Neuropathy, Diabetes Mellitus
Interventions: Clinical Evaluation, Plantar Pressure Biofeedback Gait Training, Propulsion Biofeedback Gait Training; Other
Lead sponsor: Florida Institute for Human and Machine Cognition; Other
Eligibility: 45 Years to 90 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pensacola, Florida

Conditions: PTSD
Interventions: Experimental, Active Control; Behavioral
Lead sponsor: Thomas Adams; Other
Eligibility: 21 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Depression, Anxiety, Transition
Interventions: Adapted Teens Achieving Mastery over Stress (TEAMS) Treatment, Adapted Teens Achieving Mastery over Stress (TEAMS) Prevention, Adapted Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT), Strengthening Families, Virtual psycho-educational discussion groups for caregivers and participants, Maternal Child Health Bureau (MCHB) Care Coordination; Behavioral · Other
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 13 Years to 20 Years
Enrollment: 780 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Micro Mouth Pressure Meter, Iowa Oral Performance Instrument, Electrical Impedance Myography, Capsaicin, Videofluoroscopic Swallowing Study, Pulmonary Function Testing, Swallowing Related Quality of Life Questionnaire, Functional Oral Intake Scale, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, Eating Assessment Tool-10, Communicative Effectiveness Survey, The Center for Neurologic Studies Bulbar Function Scale; Device · Drug · Procedure + 1 more
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 85 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Amyotrophic Lateral Sclerosis
Interventions: PowerLung trainer, Micro Mouth Pressure Meter, Pulmonary Function Testing, Videofluoroscopic swallowing study, Swallowing Quality of Life Questionnaire, Iowa Oral Pressure Instrument, Capsaicin; Device · Procedure · Other + 1 more
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Pain, Hip Fractures
Interventions: Femoral Nerve Block; Procedure
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 60 Years and older
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 3
States / cities: New York, New York

Conditions: Macular Edema, Cystoid, Retinal Vein Occlusion
Interventions: Standard Care, intravitreal triamcinolone injection; Other · Drug
Lead sponsor: The Emmes Company, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 682 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Caesarean Delivery
Interventions: TAP Block, Ropivacaine, Acetaminophen, Morphine; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 3
States / cities: Boston, Massachusetts • Lebanon, New Hampshire

Conditions: Cognitive Impairment
Interventions: Speed of Processing Training, Transfer Package from CI Therapy; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Traumatic Brain Injury
Interventions: Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%, Neuropsychological Assessments, Gadolinium contrast infusion, Blood sample collection for research purposes, Structural brain Magnetic Resonance Imaging (MRI; Drug · Device · Other + 1 more
Lead sponsor: Uniformed Services University of the Health Sciences; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Healthy Young, Healthy Aging, Stroke
Interventions: Experimental: Treadmill training, Experimental: Overground training, Experimental: Surefooted training; Other
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years to 90 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Attention Deficit Hyperactivity Disorder
Interventions: Computerized Progressive Attention Training, Sham Comparator Cognitive Training; Other
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 7 Years to 12 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Vision, Healthy, Attention
Interventions: Mixed trials, Blocked Trials; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cerebral Palsy
Interventions: reprogramming assisted communication device interface; Device
Lead sponsor: University of Southern California; Other
Eligibility: 5 Years to 25 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2014
U.S. locations: 1
States / cities: Stanford, California

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Food Response Training for Binge Eating

Temple Health Chest Initiative (THCI 2.0)

PRE-ISPY Phase I/II Oncology Platform Program

Investigation of Oscillations Underlying Human Cognitive and Affective Processing Using Intracranial EEG

Delineating Swallowing Impairment and Decline in ALS

Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

Exoskeletal Support in Stroke

Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

Real-Time fMRI Feedback Effects on Pain Perception

Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders

Innovative Multi-Variable Biofeedback for Improving Gait Performance in Individuals With Diabetic Peripheral Neuropathy

Exercise and Therapeutic Exposure

BEhavioral Health Stratified Treatment (BEST) Study for Youth With Intellectual and/or Developmental Disabilities (IDD)

Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS)

Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)

Improving Pain and Function in Hip Fracture

The Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study

Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone

Improving Thinking in Everyday Life: Pilot Study A

Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military

Reactive Balance Training for Fall Prevention

Cognitive Training Trial

Mixed Vs Blocked Search: Four Unique Tasks

Optimizing Assisted Communication Devices for Children With Motor Impairments Using a Model of Information Rate and Channel Capacity