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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Bone Marrow Concentrate treatment Clear all
Completed Phase 3 Interventional Results available

Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)

NCT03818737
View directory record Official record
Conditions
Osteoarthritis
Interventions
Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs, Corticosteroid injection
Biological · Drug
Lead sponsor
Emory University
Other
Eligibility
40 Years to 70 Years
Enrollment
475 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
5
States / cities
Gulf Breeze, Florida • Atlanta, Georgia • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 23, 2026, 8:20 PM EDT
Withdrawn No phase listed Observational

Case Series on Using Bone Marrow Concentrate for Alar Ligament Injuries

NCT03557606
View directory record Official record
Conditions
Craniocervical Injuries
Interventions
Alar treatment with BMC using anterior approach
Procedure
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Sep 23, 2026, 8:20 PM EDT
Terminated Not applicable Interventional

Open Ended Trocar vs. Fenestrated Blunt Trocar in Bone Marrow Aspirate for Osteoarthritis

NCT03579407
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
BMA cell therapy injection
Procedure
Lead sponsor
Advanced Orthopaedic Specialists
Other
Eligibility
18 Years to 79 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 23, 2026, 8:20 PM EDT
Terminated No phase listed Observational

A Controlled Surveillance of the Osteoarthritic Knee Microenvironment With Regenexx® SD Treatment

NCT02370823
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Regenexx SD
Procedure
Lead sponsor
Regenexx, LLC
Industry
Eligibility
35 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Sep 23, 2026, 8:20 PM EDT
Terminated Phase 1 Interventional

CAM Procedure With BMAC for Shoulder OA

NCT04826224
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure.
Biological
Lead sponsor
Shane A. Shapiro
Other
Eligibility
50 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis

NCT04716803
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Bone Marrow Aspirate Concentrate, Angel Concentrated Platelet Rich Plasma (cPRP) System
Biological · Device
Lead sponsor
University of California, San Diego
Other
Eligibility
45 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Sep 23, 2026, 8:20 PM EDT
Not yet recruiting Not applicable Interventional

Effect of HBOT on Femoral Head Avascular Necrosis (AVN)

NCT06931301
View directory record Official record
Conditions
Osteonecrosis, Avascular Necrosis
Interventions
Hyperbaric Oxygen Therapy
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2035
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Biologic Injection For Adults With Lumbar Disc Herniation

NCT07386548
View directory record Official record
Conditions
Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar, Degenerative Disc Disease, Lumbar, Lumbar Disc Herniation, Disc Herniation, Lumbar, Bone Marrow Aspirate Concentrate, Intervertebral Disc Displacement, Low Back Pain, Chronic Low Back Pain (CLBP), CLBP - Chronic Low Back Pain
Interventions
Bone Marrow Aspirate Concentrate (BMAC)
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Autologous Bone Marrow Concentrate in Treatment of Erectile Dysfunction.

NCT03699943
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
CaverStem
Procedure
Lead sponsor
Creative Medical Health, Inc.
Industry
Eligibility
18 Years to 85 Years · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Sep 23, 2026, 8:20 PM EDT
Not listed Not applicable Interventional

A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Concentrate (BMAC) for Single Level Discogenic Low Back Pain

NCT03912454
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Degeneration
Interventions
Autologous Bone Marrow Aspirate Concentrate (BMAC) Injection
Other
Lead sponsor
Bone and Joint Clinic of Baton Rouge
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries

NCT03517761
View directory record Official record
Conditions
Craniocervical Injuries
Interventions
Bone Marrow Concentrate treatment, Sham Control
Biological · Other
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting No phase listed Observational

Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear

NCT03909139
View directory record Official record
Conditions
Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate, Mesenchymal Stromal Cell
Interventions
BMAC
Biological
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
400 participants
Timeline
2019 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Autologous Bone Marrow Concentrate in Knee Osteochondral Allograft Transplantation

NCT04739930
View directory record Official record
Conditions
Cartilage Injury
Interventions
Autologous bone marrow aspirate will be harvested and concentrated to a bone marrow aspirate concentrate (BMAC) containing bone marrow derived mesenchymal stem cells and delivered to site of operation, Control group incision
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Regenexx™ SD Versus Exercise Therapy for Rotator Cuff Tears

NCT01788683
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Regenexx SD, Exercise Therapy
Procedure · Other
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 23, 2026, 8:20 PM EDT
Not listed No phase listed Observational

Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft

NCT01746212
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation
Procedure · Biological · Device
Lead sponsor
Kansas Joint and Spine Institute
Network
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2012 · Synced Sep 23, 2026, 8:20 PM EDT
Withdrawn Not applicable Interventional

Stem Cells vs. Steroids for Discogenic Back Pain

NCT04735185
View directory record Official record
Conditions
Chronic Low Back Pain, Degenerative Disc Disease
Interventions
Autologous stem cells, Corticosteroid, Local anesthetic
Other · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 23, 2026, 8:20 PM EDT
Active, not recruiting Not applicable Interventional

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

NCT02659215
View directory record Official record
Conditions
Defect of Articular Cartilage
Interventions
Hyalofast, Microfracture
Device · Procedure
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
18
States / cities
Tempe, Arizona • Los Angeles, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Phase 4 Interventional Results available

Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

NCT03289416
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Pure PRP II, PureBMC
Combination Product
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2025 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

NCT06123481
View directory record Official record
Conditions
Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head
Interventions
Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
10
States / cities
Los Angeles, California • Stanford, California • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection

NCT05985785
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Autologous bone marrow aspirate concentrate (BMAC), Corticosteroid injections, Crossover Autologous bone marrow aspirate concentrate (BMAC)
Other · Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Phase 3 Interventional

Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)

NCT01245335
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
BMAC injection, Placebo injection
Device
Lead sponsor
Harvest Technologies
Industry
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
34
States / cities
Birmingham, Alabama • El Dorado, Arkansas • Los Angeles, California + 30 more
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Sep 23, 2026, 8:20 PM EDT
Terminated Not applicable Interventional Results available

Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)

NCT01049919
View directory record Official record
Conditions
Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions
Bone marrow concentration device, Placebo procedure (sham)
Device · Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
25
States / cities
Little Rock, Arkansas • Sacramento, California • Miami, Florida + 20 more
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Bone Marrow Aspirate Concentrate (BMAC) Supplementation for Osteochondral Lesions

NCT02011295
View directory record Official record
Conditions
Osteochondral Lesions of Talus
Interventions
ankle arthroscopy with debridement and microfracture of the OLT, Bone Marrow Aspirate injection
Procedure · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 95 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Sep 23, 2026, 8:20 PM EDT
Completed Not applicable Interventional Results available

Prospective Study of Thoracolumbar Spinal Fusion Graft

NCT02297256
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
BMAC & Allograft, Iliac Crest Bone Graft
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
3
States / cities
New York, New York • Westbury, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 23, 2026, 8:20 PM EDT