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Showing 1–24 of 178 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Brain Games Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Healthy Children and Virtual Reality Mediation of Simulated Pain

NCT06854991
View directory record Official record
Conditions
Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
Interventions
Active VR-PAT, Passive VR-PAT, iPad
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Recruiting Not applicable Interventional

Brain Stimulation and Cognitive Training for MCI

NCT07526740
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Mild Neurocognitive Disorder, Neurocognitive Disorders, Cognitive Dysfunction, Cognition Disorders
Interventions
Accelerated iTBS, Computerized Cognitive Training, Sham Computerized Cognitive Training
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
60 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Brain Health Virtual Reality Study

NCT06124339
View directory record Official record
Conditions
Aging, Aging Problems, Memory Loss, Memory Impairment, Memory Disorders in Old Age, Memory Disorder, Spatial, Memory Disorders, Mild Cognitive Impairment, Cognitive Decline, Cognitive Change, Cognition Disorders in Old Age
Interventions
Physical Activity, Cognitive Activity (VR), Physical and Cognitive Activity
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
50 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Not listed Not applicable Interventional

Remotely Deployed TBI Study

NCT01882244
View directory record Official record
Conditions
Brain Injury
Interventions
Neural Pathfinder Training, Brain Health Education
Behavioral
Lead sponsor
VA Northern California Health Care System
Federal
Eligibility
24 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
2
States / cities
Martinez, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 28, 2018 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

INSIGHT, A Comprehensive, Multidisciplinary Brain Training System

NCT02780739
View directory record Official record
Conditions
Cognitive Ability, General
Interventions
Cognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS, Cognitive Training - 20 sessions
Behavioral · Device
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 44 Years
Enrollment
521 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2016 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Translational Health After School Program on Health-Related Knowledge/Behaviors and Exercise Perception

NCT02932813
View directory record Official record
Conditions
Changes in Physical Fitness, Changes in Diet, Food, and Nutrition Habits, Changes in Child Health
Interventions
THINK Program
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
8 Years to 12 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Sep 3, 2026, 5:05 AM EDT
Recruiting Not applicable Interventional

GAMES Intervention in MCI (Mild Cognitive Impairment)

NCT07296133
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Online Gameplay Intervention, Waitlist control
Behavioral
Lead sponsor
Emory University
Other
Eligibility
50 Years to 85 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 3, 2026, 5:05 AM EDT
Recruiting Not applicable Interventional

Virtual Reality (VR) -Directed Brain Gut Behavioral Treatment (BGBT) for Inflammatory Bowel Disease (IBD) Inpatients

NCT06188793
View directory record Official record
Conditions
Inflammatory Bowel Diseases
Interventions
Virtual reality-directed BGBT
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Results available

RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms

NCT05965752
View directory record Official record
Conditions
Long COVID, Long COVID-19, Long COVID19
Interventions
BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE, tDCS-active, tDCS-sham
Other · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
328 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
24
States / cities
Phoenix, Arizona • Tucson, Arizona • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional

Cognitive Rehabilitation for Post-COVID-19 Cognitive Impairment

NCT05498493
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Cognitive Rehabilitation, Brain Health Education Program
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Active Approach to Treat Amblyopia: Video Game Play

NCT01223716
View directory record Official record
Conditions
Amblyopia
Interventions
Perceptual learning, Video Game, Crossover (Occlusion therapy + Video Game)
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
5 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Sep 3, 2026, 5:05 AM EDT
Not listed Not applicable Interventional

Restoring Grasp Ability in Stroke Survivors Through MI-Based Training

NCT06307834
View directory record Official record
Conditions
Stroke
Interventions
Neurofeedback - based therapy, Standard hand exercise therapy
Behavioral
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Enhancement Training Towards Elders Resilience to Aging

NCT03197454
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Iowa City, Iowa • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional

Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI

NCT02922569
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Mindfulness Training, Traumatic Brain Injury Information Session
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Results available

Movement-based Infant Intervention

NCT03082313
View directory record Official record
Conditions
Infant Development, Infant,Premature, Infant, Very Low Birth Weight, Infant, Small for Gestational Age, Infant Conditions
Interventions
Movement Intervention
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
3 Months to 9 Months
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional

Effect of Computerized Cognitive Training in Persons With MS

NCT05345288
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
BrainHQ cognitive training, BrainHQ control games
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 60 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional

ABC Brain Games Self-Regulation Intervention

NCT03060863
View directory record Official record
Conditions
Obesity, Self-Regulation
Interventions
2. Executive Functioning, 3. Food Bias, 4. Emotion Regulation, 5. Future orientation
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
9 Years to 12 Years
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 3, 2026, 5:05 AM EDT
Not yet recruiting Not applicable Interventional

VR-PAT and fNIRS to Identify CNS Biomarkers of Pain

NCT06303687
View directory record Official record
Conditions
Acute Pain, Pediatric ALL, Procedural Pain, Burns
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional

Novel Adaptive Cognitive Training in Autistic Adults With Co-occurring Insomnia

NCT06291298
View directory record Official record
Conditions
Autism Spectrum Disorder, Insomnia
Interventions
COGMUSE-AUT
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Strategic Training to Optimize Neurocognitive Functions in Older Adults

NCT03988829
View directory record Official record
Conditions
Cognitive Aging, Functional Magnetic Resonance Imaging
Interventions
Low-C, High-C+
Behavioral
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 90 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 3, 2026, 5:05 AM EDT
Completed No phase listed Observational

Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study

NCT06245005
View directory record Official record
Conditions
Cognitive Decline
Interventions
Brain exercise gameplay on a portable electronic device
Device
Lead sponsor
Ohio State University
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Completed Not applicable Interventional Results available

Computer Assisted Cognitive Rehabilitation for Persons With Multiple Sclerosis

NCT03200899
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
MAPSS-MS, Usual Care plus computer games
Behavioral · Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 60 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 3, 2026, 5:05 AM EDT
Recruiting Not applicable Interventional

Promoting Neuroplastic Changes of Patients With TBI

NCT06465290
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Motor relearning training with wearable ankle robot, Passive stretching with wearable ankle robot, Gamed-based active movement training with wearable ankle robot, Passive movement with limited wearable ankle robot, Active movement training with limited wearable ankle robot, Ankle/Wrist torque and motion measurement with limited wearable ankle/wrist robot
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
30 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 3, 2026, 5:05 AM EDT
Active, not recruiting Not applicable Interventional

Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure

NCT05601817
View directory record Official record
Conditions
Heart Failure, Mild Cognitive Impairment
Interventions
Vita, Com, Vita+Com
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
55 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 3, 2026, 5:05 AM EDT