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ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:13 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 1,029 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Brain surgery Clear all
Active, not recruiting Not applicable Interventional

DBS of the Lateral Habenula in Treatment-Resistant Depression

NCT01798407
View directory record Official record
Conditions
Treatment Resistant Major Depressive Disorder
Interventions
Activa Tremor Control Sys (DBS Implant), Randomized, staggered withdrawal phase
Device · Other
Lead sponsor
Wayne Goodman MD
Other
Eligibility
21 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 19, 2026, 4:13 PM EDT
Completed Phase 3 Interventional Results available

Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial

NCT00056563
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Bilateral Deep Brain Stimulation, best medical therapy
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
22 Years and older
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
14
States / cities
Los Angeles, California • San Francisco, California • West Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated May 9, 2014 · Synced Oct 19, 2026, 4:13 PM EDT
No Longer Available No phase listed Expanded access

TVI-Brain-1 in Expanded Access Patient

NCT05936216
View directory record Official record
Conditions
Recurrent Glioblastoma
Interventions
TVI-Brain 1
Biological
Lead sponsor
TVAX Biomedical
Industry
Eligibility
18 Years to 80 Years
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 19, 2026, 4:13 PM EDT
Recruiting Early Phase 1 Interventional

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

NCT07493447
View directory record Official record
Conditions
Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer, Pituitary Adenoma
Interventions
Panitumumab-IRDye800
Drug
Lead sponsor
Eben Rosenthal
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Completed No phase listed Observational

Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)

NCT00391378
View directory record Official record
Conditions
Stroke, Cognitive Symptoms
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
363 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 19, 2026, 4:13 PM EDT
Completed Phase 3 Interventional

Radiation Therapy With or Without Radiosurgery in Treating Patients With Brain Metastases

NCT00002708
View directory record Official record
Conditions
Metastatic Cancer
Interventions
surgical procedure, radiation therapy, stereotactic radiosurgery
Procedure · Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2004
U.S. locations
240
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 184 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2013 · Synced Oct 19, 2026, 4:13 PM EDT
Enrolling by invitation Not applicable Interventional

Effects of Stimulation Patterns of Deep Brain Stimulation

NCT02553525
View directory record Official record
Conditions
Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
Interventions
Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
Procedure
Lead sponsor
Duke University
Other
Eligibility
21 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
3
States / cities
Gainesville, Florida • Atlanta, Georgia • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating Raised Intracranial Pressure Using MR Elastography

NCT03096743
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension
Interventions
MR elastography, MRI structural brain imaging, Lumbar puncture, Optical Coherence Tomography (OCT) imaging, Optic nerve B-scan ultrasound
Diagnostic Test · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2031
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Completed No phase listed Observational

Cerebral Oximeter Comparison Study

NCT01655940
View directory record Official record
Conditions
Cardiac Bypass Patients
Interventions
Somanetics cerebral oximeter, CASMED cerebral oximeter
Device
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2012 · Synced Oct 19, 2026, 4:13 PM EDT
Completed Phase 2 Interventional

Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma

NCT00752323
View directory record Official record
Conditions
Brain and Central Nervous System Tumors
Interventions
aminolevulinic acid, Surgical Resection
Drug · Procedure
Lead sponsor
Andrew Sloan, MD
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 19, 2026, 4:13 PM EDT
Recruiting Phase 1 Interventional

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

NCT06193759
View directory record Official record
Conditions
Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS, Embryonal Tumor With Multilayered Rosettes, Pineoblastoma, Embryonal Brain Tumor Not Otherwise Specified, Recurrent Ependymoma
Interventions
Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy
Biological · Drug · Radiation
Lead sponsor
Children's National Research Institute
Other
Eligibility
1 Year to 30 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Recruiting Not applicable Interventional

Visuomotor Prosthetic for Paralysis

NCT01958086
View directory record Official record
Conditions
Quadriplegia
Interventions
Neural Communication System
Device
Lead sponsor
Richard A. Andersen, PhD
Other
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2031
U.S. locations
3
States / cities
Los Angeles, California • Pasadena, California • Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Enrolling by invitation Not applicable Interventional

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

NCT07226908
View directory record Official record
Conditions
Epilepsy
Interventions
Cognitive experiment, Electrical stimulation of the brain
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 19, 2026, 4:13 PM EDT
Withdrawn No phase listed Observational

STAMCAR: A Prospective EC-IC Bypass Registry

NCT02779803
View directory record Official record
Conditions
Carotid Occlusion
Interventions
EC-IC bypass
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Miami, Florida • Chicago, Illinois • Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 4, 2022 · Synced Oct 19, 2026, 4:13 PM EDT
Recruiting Phase 1Phase 2 Interventional

000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

NCT05588141
View directory record Official record
Conditions
Brain Tumor, Cancer
Interventions
Zotiraciclib
Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
15 Years to 99 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Active, not recruiting Phase 3 Interventional

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

NCT01592968
View directory record Official record
Conditions
Metastatic Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain
Interventions
Cognitive Assessment, Quality-of-Life Assessment, Stereotactic Radiosurgery, Whole-Brain Radiotherapy
Other · Radiation
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Completed Not applicable Interventional

A Phase II Trial of CyberKnife Radiosurgery to Perioptic Tumors

NCT02225197
View directory record Official record
Conditions
Tumor, Benign, Optic Nerve
Interventions
CyberKnife Radiosurgery
Radiation
Lead sponsor
Community Cancer Center, Normal, Illinois
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2017
U.S. locations
1
States / cities
Normal, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 19, 2026, 4:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NIRS Guidance Trail in Children's Heart Surgery

NCT02157597
View directory record Official record
Conditions
Heart Defects, Congenital
Interventions
NIRS based management, Control
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 6 Months
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Oct 19, 2026, 4:13 PM EDT
Active, not recruiting Phase 2 Interventional

Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study

NCT04690348
View directory record Official record
Conditions
Recurrent Brain Metastases
Interventions
Craniotomy, Cesium-131 brachytherapy
Procedure · Radiation
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
6
States / cities
Miami, Florida • Basking Ridge, New Jersey • Middletown, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 19, 2026, 4:13 PM EDT
Active, not recruiting Phase 3 Interventional

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

NCT04365374
View directory record Official record
Conditions
Brain Metastases
Interventions
Gamma Tile-Surgically Targeted Radiation Therapy (STaRT), Stereotactic Radiation Therapy
Device · Radiation
Lead sponsor
GT Medical Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
37
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Jacksonville, Florida + 28 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 19, 2026, 4:13 PM EDT
Withdrawn No phase listed Observational

Analysis of Cerebral Perfusion Using Head Ultrasound and Multisource Detector Near Infrared Spectroscopy (NIRS) Imaging

NCT01082536
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Up to 2 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Oct 19, 2026, 4:13 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT)

NCT04985032
View directory record Official record
Conditions
Ductal Carcinoma in Situ, Invasive Ductal Carcinoma of Female Breast
Interventions
stereotactic body radiation therapy
Radiation
Lead sponsor
RPCR, Inc.
Other
Eligibility
50 Years to 100 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
2
States / cities
Stuart, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2022 · Synced Oct 19, 2026, 4:13 PM EDT
Terminated Phase 2 Interventional Results available

Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery

NCT02097732
View directory record Official record
Conditions
Metastatic Melanoma, Brain Metastases
Interventions
Ipilimumab, Stereotactic Radiosurgery
Drug · Procedure
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Oct 19, 2026, 4:13 PM EDT
Not listed No phase listed Observational

ICG Angiogram as a Predictor of Postoperative Visual Function After EEA Surgery

NCT06501716
View directory record Official record
Conditions
Indocyanine Green, Skull Base Neoplasms
Interventions
Indocyanine Green
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 19, 2026, 4:13 PM EDT