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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Brainsonix Ultrasound Device Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Focused Ultrasound for the Treatment of Neuropathic Pain

NCT04485208
View directory record Official record
Conditions
Neuropathic Pain
Interventions
Focused Ultrasound
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 26, 2026, 9:00 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

tFUS Induced Transient Scotoma for Individual Dosing

NCT06426498
View directory record Official record
Conditions
Healthy
Interventions
Brainsonix Bx Pulsar machine tFUS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Completed Not applicable Interventional

Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety

NCT05147142
View directory record Official record
Conditions
Depression
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Ocean State Research Institute, Inc.
Other
Eligibility
22 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Not listed Early Phase 1 Interventional

Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor

NCT05475340
View directory record Official record
Conditions
Tremor, Parkinson Disease, Essential Tremor
Interventions
Focused Ultrasound
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 26, 2026, 9:00 AM EDT
Active, not recruiting Early Phase 1 Interventional

Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder

NCT06482762
View directory record Official record
Conditions
Bipolar
Interventions
BrainSonix Pulsar 1002
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Recruiting Phase 2 Interventional

Focused Ultrasound for PTSD in Veterans

NCT06820138
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Brainsonix Ultrasound Device
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Recruiting Not applicable Interventional

Ultrasound Stimulation for Patients in a Disorder of Consciousness

NCT06939348
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Recruiting Early Phase 1 Interventional

Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor

NCT07599592
View directory record Official record
Conditions
Essential Tremor
Interventions
Low Intensity Focused Ultrasound (LIFU)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Recruiting Not applicable Interventional

Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

NCT07668882
View directory record Official record
Conditions
Stuttering, Developmental Stuttering
Interventions
High DC LIFU, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation of Mind-Wandering in Depression

NCT04832685
View directory record Official record
Conditions
Depression
Interventions
BrainSonix Pulsar 1002
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 26, 2026, 9:00 AM EDT
Not listed Early Phase 1 Interventional

Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty

NCT04770350
View directory record Official record
Conditions
Frailty, Aging
Interventions
Focused Ultrasound
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
45 Years to 95 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 26, 2026, 9:00 AM EDT
Not listed Not applicable Interventional

Focused Ultrasound for the Treatment of ADHD Symptoms

NCT04497363
View directory record Official record
Conditions
ADHD
Interventions
Brainsonix Pulsar 1002
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 26, 2026, 9:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement

NCT07190287
View directory record Official record
Conditions
Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
Interventions
NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 26, 2026, 9:00 AM EDT
Not listed Not applicable Interventional

The Use of Transcranial Ultrasound Treatment of Obsessive-Compulsive Disorder

NCT04775875
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Focused Ultrasound
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 26, 2026, 9:00 AM EDT
Enrolling by invitation Not applicable Interventional

The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

NCT04063514
View directory record Official record
Conditions
Low Grade Glioma of Brain
Interventions
Focused Ultrasound
Other
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 26, 2026, 9:00 AM EDT