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Showing 1–24 of 128 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Brief PTSD treatment Clear all
Completed Not applicable Interventional

Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

NCT06646692
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Anxiety, Depression - Major Depressive Disorder
Interventions
Mindful Self Compassion, Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Not yet recruiting Not applicable Interventional

Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial

NCT07782268
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Written Exposure Therapy, Treatment as Usual
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tai Chi and Wellness Education for Older Veterans

NCT03624868
View directory record Official record
Conditions
Physical Activity, PTSD, Satisfaction
Interventions
Tai Chi, Wellness Education
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
60 Years to 100 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional

The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions

NCT04245423
View directory record Official record
Conditions
Opioid-use Disorder, Mental Health Conditions
Interventions
Collaborative Care for Opioid Use Disorders and Mental Health Conditions, Augmented Usual Care, Collaborative Care for Opioid Use Disorders and Mental Health Conditions Plus Certified Recovery Specialists
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
567 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention

NCT07288593
View directory record Official record
Conditions
Nightmare, Insomnia, PTSD, TBI, Sleep Disorder (Disorder), REM Behavior Disorder
Interventions
NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment)
Device
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 62 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

NCT06210711
View directory record Official record
Conditions
Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions
Treatment as Usual, Brief Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Phase 2Phase 3 Interventional

RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD)

NCT03827057
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Reconsolidation of Traumatic Memories (RTM), Prolonged Exposure (PE)
Behavioral
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 20, 2026, 7:02 AM EDT
Not listed Not applicable Interventional

Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART)

NCT04121884
View directory record Official record
Conditions
Depressive Symptoms, Stress Disorder, Acute, Prolonged Grief Disorder, Alcohol Abuse, Stress Disorders, Post-Traumatic
Interventions
Accelerated Resolution Therapy
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 20, 2026, 7:02 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Assessing and Enhancing Social Support

NCT05187156
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Behavioral Activation and Social Engagement, Treatment as usual
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional

Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

NCT05267665
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Brief Family Intervention (BFI)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Boston, Massachusetts • Durham, North Carolina • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional

Written Versus Verbal Brief Cognitive Behavioral Exposure Therapy

NCT04000217
View directory record Official record
Conditions
Written Exposure Therapy, Imaginal Exposure Therapy
Interventions
Written Exposure Therapy, Imaginal Exposure Therapy
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents

NCT03737383
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Use Disorders
Interventions
Narrative Exposure Therapy
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
16 Years to 25 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Results available

An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment

NCT02956434
View directory record Official record
Conditions
Posttraumatic Neuroses
Interventions
Brief Family Intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Sep 20, 2026, 7:02 AM EDT
Terminated Not applicable Interventional

New Beginnings Following Trauma

NCT05817344
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions
Written Exposure Therapy - Integrated
Behavioral
Lead sponsor
Jesse McCann
Other
Eligibility
18 Years to 100 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

NCT07079761
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Experiment 1. Three-day aversive conditioning, extinction, and extinction retention testing paradigm, Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer., Matching IV Placebo, Experiment 2. Three-day aversive conditioning, reconsolidation blockade, and testing paradigm
Behavioral · Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 20, 2026, 7:02 AM EDT
Not listed Not applicable Interventional

Online and Mobile Mindfulness Intervention to Reduce Distress

NCT04035304
View directory record Official record
Conditions
PTSD
Interventions
Mindfulness Coach
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional

Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

NCT05457985
View directory record Official record
Conditions
PTSD
Interventions
Prolonged Exposure for Primary Care (PE-PC), Full Prolonged Exposure, Clinician Supported PTSD Coach App
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
13
States / cities
Baldwin, Michigan • Battle Creek, Michigan • Flint, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional

Building Healthy Eating and Self-Esteem Together for University Students

NCT07060534
View directory record Official record
Conditions
Eating Disorders (Excluding Anorexia Nervosa), Binge-Eating Disorder
Interventions
Building Healthy Eating and Self-Esteem Together for University Students, Present-Centered Therapy
Behavioral
Lead sponsor
University of Kansas
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lawrence, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

NCT05751473
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
14
States / cities
San Diego, California • Carrollton, Georgia • Ann Arbor, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder

NCT05780177
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Insomnia Disorder
Interventions
Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional

Occupational Therapy Driving Intervention for Returning Combat Veterans.

NCT02764983
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Post Traumatic Stress Disorder (PTSD)
Interventions
Driving Behavior Interview, Fitness-to-Drive Screening Measure, Clinical Driving Assessment, Propensity for Angry Driving Scale, Community Integration Questionnaire, Satisfaction with Life Questionnaire, Driving simulator evaluation, Focus Group Discussion Interview Guide
Behavioral · Other · Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2018 · Synced Sep 20, 2026, 7:02 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD

NCT05037175
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
CPT-Text, Culturally Informed Trauma Treatment (CITT), Retention Incentive, Reminder as Usual
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
3
States / cities
Palo Alto, California • New York, New York • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional

Dismantling Exposure, Relaxation, and Rescripting Therapy

NCT02236377
View directory record Official record
Conditions
Frequent Trauma-related Nightmares
Interventions
Exposure, Relaxation, and Rescripting Therapy
Behavioral
Lead sponsor
University of Tulsa
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Results available

Primary Care Treatment Integrating Motivation and Exposure

NCT03812146
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Alcohol-Related Disorders
Interventions
PC-TIME, PC-TAU
Behavioral
Lead sponsor
Syracuse VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Buffalo, New York • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Sep 20, 2026, 7:02 AM EDT