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Showing 1–24 of 101 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Brief motivational substance use intervention Clear all
Completed Not applicable Interventional

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

NCT02093559
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
Brief counseling Intervention
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Behavioral Treatment of Drug Abuse in Severe and Persistent Mental Illness (SPMI) Patients

NCT00295139
View directory record Official record
Conditions
Schizophrenia, Mood Disorders, Substance Dependence
Interventions
Behavioral Treatment for Substance Abuse in SPMI (BTSAS), Supportive Treatment in Addiction Recovery (STAR), Critical Time Intervention (CTI)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 55 Years
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
4
States / cities
Baltimore, Maryland • Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Drug Use and Sexual Risk Behaviors Among Emerging Adults in the ER

NCT03079856
View directory record Official record
Conditions
Drug Use, Sex Behavior
Interventions
Brief Intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Reproductive Health for Women in Opioid Medication-Assisted Treatment (OMAT)

NCT02794597
View directory record Official record
Conditions
Contraception
Interventions
SHINE intervention group
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 15, 2020 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency Department

NCT01113190
View directory record Official record
Conditions
Drug Abuse
Interventions
Computer-delivered Brief Intervention (CBI), Intervener-delivered Brief Intervention (IBI), Adapted Motivational Enhancement Therapy (AMET), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
878 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 6, 2016 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Improving Brief Marijuana Interventions With a Behavioral Economic Supplement

NCT02837315
View directory record Official record
Conditions
Marijuana Use
Interventions
Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session
Behavioral
Lead sponsor
University of Memphis
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Brief Intervention for Justice-Involved Substance Users

NCT03308877
View directory record Official record
Conditions
Substance Use, Violence
Interventions
BMI, Stadard Care (SC)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients

NCT01671501
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome, Alcoholism, Alcoholic Intoxication, Substance-Related Disorders
Interventions
Motivational Interviewing, Email Feedback, Usual Care
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
614 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computerized Screening, Brief Intervention, and Referral to Treatment in Primary Care

NCT01003834
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Computerized brief intervention, Computerized health screening, Computerized assessment, Therapist-delivered motivational intervention
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
713 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adaptive Preventive Intervention for College Alcohol Use

NCT03930524
View directory record Official record
Conditions
College Student Drinking
Interventions
Personalized Normative Feedback (PNF), Self-Monitoring (SM), Web-BASICS, Health Promotion Consultation, M-Bridge Online Health Coach
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 21 Years
Enrollment
891 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 27, 2026, 6:42 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Parent Intervention to Reduce College Student Drinking and Consequences

NCT04247191
View directory record Official record
Conditions
Underage Drinking, Driving Under the Influence, Drinking, Teen, Drinking, College
Interventions
P-Chat+, PBI
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 19 Years
Enrollment
2,061 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Brief Therapies for Problem Gambling Substance Abusers

NCT00685048
View directory record Official record
Conditions
Gambling
Interventions
10 minutes of psycho-education, 10 minutes of brief advice, four 50-minute individual therapy sessions of MET & CBT
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Preventing Violence Among Veterans in Substance Use Disorder Treatment

NCT01337973
View directory record Official record
Conditions
Aggression, Substance-Related Disorders
Interventions
MI-CBT, MI-CBT+CC, E-TAU
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Choices4Health: Intervention to Prevent Substance-exposed Pregnancy

NCT03633149
View directory record Official record
Conditions
Prenatal Alcohol Exposure, Prenatal Tobacco Exposure, Prenatal Marijuana Exposure
Interventions
Computer tablet-delivered C4H, Person-delivered C4H, Brief Advice
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2022 · Synced Sep 27, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The STop UNhealthy Substance Use Now Trial

NCT06524232
View directory record Official record
Conditions
Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions
Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

NCT03362476
View directory record Official record
Conditions
Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
Interventions
Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care
Behavioral
Lead sponsor
New York University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

NCT03838510
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
REBOOT
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
San Francisco, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

NCT05471921
View directory record Official record
Conditions
Alcohol and Substance-Related Mental Disorders
Interventions
SBIRT, Treatment as usual
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Recruiting Not applicable Interventional

Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

NCT06736444
View directory record Official record
Conditions
Insomnia, Alcohol Use, Marijuana Use
Interventions
Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 29 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

NCT06855836
View directory record Official record
Conditions
Overdose
Interventions
MI-CHANCE (TS + FTIR + MI), TS + FTIR + Flu and Hepatitis A Education
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
588 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional

Technology Interventions for Youth Alcohol Use

NCT05988931
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Web Program + App, Web Program + App + Text Messages
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
12 Years to 19 Years
Enrollment
1,406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Substance Use and Sexual Risk Reduction Intervention for Homeless Youth

NCT02188797
View directory record Official record
Conditions
Substance Use, Sexual Risk Behavior
Interventions
Group MI risk reduction program
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 24 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Hollywood, California • Venice Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Substance Use Prevention Intervention Research Study in Pediatric Primary Care

NCT04450966
View directory record Official record
Conditions
Heavy Drinking, Driving Under the Influence, Riding With Driver Under the Influence
Interventions
Computer-facilitated Screening and Brief Intervention
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 17 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Itasca, Illinois • Boston, Massachusetts • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 27, 2026, 6:42 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Computer-based Brief Intervention for Perinatal Substance Abuse

NCT00685074
View directory record Official record
Conditions
Substance Abuse
Interventions
Computer-based Motivational Interviewing, Time control
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2011 · Synced Sep 27, 2026, 6:42 PM EDT