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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:16 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 103 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Brief motivational substance use intervention Clear all

Conditions: Alcohol Consumption, Alcohol Use Disorder (AUD), Substance Use (Drugs, Alcohol), Substance Use Disorder (SUD), Condomless Sex, Unprotected Sex, High-risk Sex
Interventions: AWARE; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years to 25 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2029
U.S. locations: 3
States / cities: Los Angeles, California • Venice, California • Pittsburgh, Pennsylvania

Conditions: Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
Interventions: Relational Agent Intervention; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alcohol Abuse
Interventions: Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session; Behavioral
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years to 27 Years
Enrollment: 393 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Columbia, Missouri • Memphis, Tennessee

Conditions: Opioid Use Disorder, Dual Diagnosis, Housing Problems, Mental Disorder in Adolescence, Risk Behavior, Homelessness
Interventions: Motivational Interviewing/Community Reinforcement Approach (MI/CRA), Strengths-Based Outreach and Advocacy (SBOA ), Services as Usual (SAU); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 14 Years to 24 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Columbus, Ohio

Conditions: Contraception
Interventions: SHINE intervention group; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 119 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Opioid-Related Disorders
Interventions: Behavioral: the OPT-IN Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Pain, Substance Use, Opioid Misuse, Quality of Life
Interventions: M2VA Pain Care Pathway (M2VAPCP), Implementation Facilitation; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 1,800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Substance Use
Interventions: Motivational Interviewing; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 99 Years
Enrollment: 827 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 39
States / cities: Phoenix, Arizona • Claremont, California • Irvine, California + 32 more

Conditions: Alcohol Abuse
Interventions: Brief Alcohol Intervention (BAI), Substance-free Activity Session (SFAS), Relaxation Training (RT), Education Control; Behavioral · Other
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years to 29 Years
Enrollment: 525 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
Interventions: Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 615 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Opioid Use Disorder, Opioid Misuse
Interventions: Opioid Misuse Screening with an Addiction Consult Service; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 47,502 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: HIV, Substance Use Disorders, Substance Use, AIDS
Interventions: CC PrTNER; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 15 Years to 29 Years · Male only
Enrollment: 275 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Baltimore, Maryland • Philadelphia, Pennsylvania

Conditions: Substance Use Disorders, Mental Illness
Interventions: SBIRT, Health Education; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 1,080 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: Los Angeles, California • Oxnard, California

Conditions: Substance Use
Interventions: Standard Screening, Standard Psychoeducation, Standard Brief Negotiated Interview (BNI), Standard Referral to Treatment (RT), Family Screening, Family Psychoeducation, Family Brief Negotiated Interview (BNI), Family Facilitated Conversation (FC) & Referral to Treatment (RT); Behavioral
Lead sponsor: The National Center on Addiction and Substance Abuse at Columbia University; Other
Eligibility: 12 Years to 17 Years
Enrollment: 2,300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance-Related Disorders
Interventions: Brief intervention using motivational interviewing; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 868 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Alcohol Abuse, Tobacco Use Disorder, Substance Use
Interventions: cMET; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 14 Years to 20 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Brief Computer Motivational Interviewing for Smoking Cessation, Nutrition Control; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Substance Abuse
Interventions: Computer Counseling, Standard Care; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 14 Years to 17 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
Interventions: Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care; Behavioral
Lead sponsor: New York University; Other
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Drinking
Interventions: Web Program + App, Web Program + App + Text Messages; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 12 Years to 19 Years
Enrollment: 1,406 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Alcohol Use Disorder, Opioid Use Disorder, Alcohol Use, Opioid Use
Interventions: Brief opioid-informed alcohol treatment; Behavioral
Lead sponsor: University of Notre Dame; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Notre Dame, Indiana

Conditions: Sexual Risk, Substance Use
Interventions: Behavioral: HIV prevention intervention; Other
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years to 29 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Drug Use
Interventions: Usual Care, QUIT Intervention (doctor brief advice, video doctor, health coaching sessions at 2- and 6-weeks), QUIT-Mobile (QUIT Intervention plus weekly mobile-web app or text message weekly self-monitoring, automated feedback over 12 months); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 457 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 5
States / cities: Long Beach, California • Los Angeles, California

Conditions: Substance Use Disorder (SUD), HIV
Interventions: ENTRUST - substance use and HIV counseling and goal setting with economic empowerment and photovoice training, SBIRT-T only; Behavioral
Lead sponsor: University of Central Florida; Other
Eligibility: 18 Years and older · Male only
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Orlando, Florida

Search by objective public record fields.

Implementing an Evidence-based Alcohol Use and Sexual Risk Intervention in Young Adult Homeless Service Settings

Relational Agent for Alcohol Screening and Treatment

Improving Brief Alcohol Interventions With a Behavioral Economic Supplement

Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness

Improving Reproductive Health for Women in Opioid Medication-Assisted Treatment (OMAT)

The OPT-IN Project

M2VA Pain Care Pathway

Substance Abuse Treatment to HIV Care (SAT2HIV): The Motivational Interviewing-based Brief Intervention Experiment

Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Emerging Adults

Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems

Natural Language Processing for Screening Opioid Misuse

The Collaborative Care PrTNER Study

Screening, Brief Intervention and Referral to Treatment for Substance Abuse in Mental Health Treatment Settings

Primary Connections for Youth and Families

Brief Intervention in Primary Care for Problem Drug Use and Abuse

Computer Adaptation of Screening, Brief MET Intervention to Reduce Teen Drinking

Motivating Quitline Use Among Smokers in Treatment for Substance Use Disorders

Computer-Assisted Brief Intervention

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

Technology Interventions for Youth Alcohol Use

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

An Innovative HIV Prevention Intervention Using Social Networking Technology

mHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care

ENTRUST - Economic Navigation and Strengthening to Realize Unrestricted Services for Transgender Women