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ClinicalTrials.gov public records Last synced Oct 9, 2026, 4:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 101 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Brief motivational substance use intervention Clear all
Completed Not applicable Interventional

SMART Trial for Buprenorphine-Naloxone Medication Assisted Treatment Adherence

NCT04080180
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Contingency Management, Brief Motivational Interviewing + Substance Free Activities + Mindfulness
Behavioral
Lead sponsor
Karen Derefinko, PhD
Other
Eligibility
18 Years and older
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 9, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

NCT06855836
View directory record Official record
Conditions
Overdose
Interventions
MI-CHANCE (TS + FTIR + MI), TS + FTIR + Flu and Hepatitis A Education
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
588 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional

Improving Brief Marijuana Interventions With a Behavioral Economic Supplement

NCT02837315
View directory record Official record
Conditions
Marijuana Use
Interventions
Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session
Behavioral
Lead sponsor
University of Memphis
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Positive Family Support Project - Partnering With Families for a Successful Transition to School

NCT02289092
View directory record Official record
Conditions
Achievement
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
848 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing HIV Counseling and Testing and Referral Through an Adaptive Drug Use Intervention

NCT02945436
View directory record Official record
Conditions
HIV, Substance Use
Interventions
Substance Use Brief Intervention, Standard of Care (SOC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
15 Years to 29 Years
Enrollment
258 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Brief Intervention in At-Risk First-time Mothers

NCT00230009
View directory record Official record
Conditions
Substance Use
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Substance Use and Sexual Risk Reduction Intervention for Homeless Youth

NCT02188797
View directory record Official record
Conditions
Substance Use, Sexual Risk Behavior
Interventions
Group MI risk reduction program
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 24 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Hollywood, California • Venice Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Personalized Feedback Programs for College Students

NCT04975191
View directory record Official record
Conditions
Alcohol Use, Unspecified
Interventions
Resources, Personalized Feedback Program (PFP), Substance Use Feedback Program (BMI)
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Oct 9, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional

Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Emerging Adults

NCT04776278
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Brief Alcohol Intervention (BAI), Substance-free Activity Session (SFAS), Relaxation Training (RT), Education Control
Behavioral · Other
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 29 Years
Enrollment
525 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional

The OPT-IN Project

NCT03526380
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Behavioral: the OPT-IN Intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Substance Use Risk Education (SURE) Project

NCT00289965
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Drinking
Interventions
Counselor-administered Brief Motivational Intervention (BMI), Alcohol 101 Plus (interactive CD-ROM), AlcoholEdu (Internet-based tutorial)
Behavioral
Lead sponsor
Syracuse University
Other
Eligibility
18 Years to 25 Years
Enrollment
703 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional

Project Health Link: Connecting Patients With Services

NCT00251173
View directory record Official record
Conditions
Drug Abuse
Interventions
Strengths Based Case Management (SBCM), Motivational Enhancement Therapy (MET), Brief Informational Feedback (BIF) session
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
19 Years to 60 Years
Enrollment
755 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 8, 2016 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional

The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions

NCT04245423
View directory record Official record
Conditions
Opioid-use Disorder, Mental Health Conditions
Interventions
Collaborative Care for Opioid Use Disorders and Mental Health Conditions, Augmented Usual Care, Collaborative Care for Opioid Use Disorders and Mental Health Conditions Plus Certified Recovery Specialists
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
567 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

NCT02093559
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
Brief counseling Intervention
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2023 · Synced Oct 9, 2026, 4:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Online System for Primary Care to Prevent and Address Teen Substance Use

NCT04689997
View directory record Official record
Conditions
Substance Use
Interventions
cSBI
Behavioral
Lead sponsor
Total Child Health, Inc.
Industry
Eligibility
12 Years to 19 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care

NCT02233946
View directory record Official record
Conditions
Prevention Harmful Effects
Interventions
computer-facilitated brief intervention
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
9 Years to 18 Years
Enrollment
871 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
5
States / cities
Boston, Massachusetts • East Boston, Massachusetts • Lexington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Oct 9, 2026, 4:05 AM EDT
Recruiting Not applicable Interventional

Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors

NCT07516301
View directory record Official record
Conditions
Survivors of Childhood Cancer, Substance Use
Interventions
WHO ASSIST v3.1 Screening with Feedback, ASSIST Linked Brief Intervention (10 Step Motivational interviewing (MI)/FRAMES), WHO ASSIST v3.1 Screening (No Feedback)
Behavioral
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
15 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 9, 2026, 4:05 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Advancing Adolescent Screening and Brief Intervention Protocols in Primary Care Settings

NCT01523444
View directory record Official record
Conditions
Substance Abuse
Interventions
computer-assisted Screening & Brief Advice, computer-assisted Screening & Brief Advice Plus
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Results available

Brief Intervention for Justice-Involved Substance Users

NCT03308877
View directory record Official record
Conditions
Substance Use, Violence
Interventions
BMI, Stadard Care (SC)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Phase 2 Interventional Results available

The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention

NCT01532934
View directory record Official record
Conditions
Substance Use, Psychopathy
Interventions
motivational enhancement therapy, standard care
Behavioral · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2016 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency Department

NCT01113190
View directory record Official record
Conditions
Drug Abuse
Interventions
Computer-delivered Brief Intervention (CBI), Intervener-delivered Brief Intervention (IBI), Adapted Motivational Enhancement Therapy (AMET), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
878 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Home Visitation Enhancing Linkages Project

NCT03750487
View directory record Official record
Conditions
Substance Use
Interventions
e-screening & brief intervention (e-SBI), Control e-SBI
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 9, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The STop UNhealthy Substance Use Now Trial

NCT06524232
View directory record Official record
Conditions
Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions
Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 9, 2026, 4:05 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

NCT05471921
View directory record Official record
Conditions
Alcohol and Substance-Related Mental Disorders
Interventions
SBIRT, Treatment as usual
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 9, 2026, 4:05 AM EDT