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ClinicalTrials.gov public records Last synced Sep 9, 2026, 5:44 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Depression, Major Depressive Disorder, Postpartum Depression
Interventions
Triple Chronotherapy, Usual Care
Behavioral · Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Recruiting Not applicable Interventional

Fibromyalgia Sleep A to ZZZ Study

NCT06567886
Conditions
Fibromyalgia
Interventions
Light Therapy, Sleep Stabilization
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Recruiting Not applicable Interventional Accepts healthy volunteers

Biomarkers for Peripheral Circadian Clocks in Humans

NCT06296823
Conditions
Circadian Rhythms
Interventions
Simulated jetlag protocol
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
17 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Conditions
Dementia, Stress, Caregiver Burden
Interventions
Stress Management Toolkit
Combination Product
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Brain Tumor
Interventions
Bright Light Exposure, Dim Light Exposure, Cognitive Assessment
Behavioral · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
10 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Conditions
Lung Cancers
Interventions
bright light
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Completed Not applicable Interventional Accepts healthy volunteers

Social & Behavioral Rhythms in Chronic Pain

NCT03022643
Conditions
Chronic Pain
Interventions
Interpersonal Social Rhythms Psychotherapy, Bright Light Device
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Conditions
Pancreatic Neoplasms, Rectal Neoplasms
Interventions
Blue light, Amber light, Ambient White Light
Device · Other
Lead sponsor
Matthew Neal MD
Other
Eligibility
19 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Results available

Feasibility Pilot of Bright Light in the Intensive Care Unit

NCT03568045
Conditions
Circadian Rhythm Sleep Disorder, Unspecified
Interventions
standard light, 10,000 lux bright light, 4 hours, 10,000 lux bright light, 8 hours
Device
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Not listed Not applicable Interventional Accepts healthy volunteers

Bright Light as a Countermeasure for Circadian Desynchrony

NCT01119365
Conditions
Healthy
Interventions
Bright light
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years to 35 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Melatonin Levels in Smith Magenis Syndrome (SMS)

NCT00691574
Conditions
Chromosome Disorders
Interventions
Melatonin, Enviro-light artificial light box
Dietary Supplement · Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
3 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2009
U.S. locations
1
States / cities
Portland, Oregon
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Light and Sleep Fragmentation

NCT06009289
Conditions
Sleep, Mild Cognitive Impairment, Mood Disorders
Interventions
Light therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
65 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Redwood City, California
Conditions
Sleep Phase Rhythm Disturbance, Sleep Deprivation
Interventions
Morning Light Therapy, Assigned Sleep Times, Goggles
Behavioral · Device
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Accepts healthy volunteers

Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms

NCT05276739
Conditions
Light Exposure, Meal Timing
Interventions
Bright Light, Time-restricted eating, Dim light, 12-h meal window
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional

Triple Chronotherapy in Adolescents

NCT03679962
Conditions
Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
Interventions
Triple Chronotherapy, Treatment as Usual
Behavioral
Lead sponsor
Billings Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Billings, Montana
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep

NCT07753889
Conditions
Circadian Rhythm, Pupillometry, Sleep
Interventions
Ocular light exposure from portable light box
Other
Lead sponsor
Elizabeth B Klerman MD PhD
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2035
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Seasonal Affective Disorder, Mood Disorders, Depression
Interventions
bright light box, dawn simulator, high-output negative ion generator, low-output negative ion generator, dawn light pulse
Device
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
1
States / cities
New York, New York
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Wearable bright light therapy device, Wearable placebo light therapy device
Device
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Cancer, Health Behavior, Depression
Interventions
Litebook® Advantage, Fitbit Flex2 TM
Other
Lead sponsor
Columbia University
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Conditions
Primary Open Angle Glaucoma
Interventions
Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination, Visual field under dim illumination (MAIA), Macular Pigment Optical Density (MPOD), Dark Adaptation
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Prader-Willi Syndrome, Excessive Daytime Sleepiness, Hyperphagia, Body Weight, Mood, Behavior
Interventions
Sham Light, Bright Light Therapy
Other
Lead sponsor
Maimonides Medical Center
Other
Eligibility
6 Years to 88 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Conditions
Unipolar Depression
Interventions
Bright light therapy, dim red light
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Neoplasms, Fatigue
Interventions
Bright White Light, Dim Red Light
Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
12 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee