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ClinicalTrials.gov public records Last synced Nov 6, 2026, 2:50 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 817–840 of 975 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Bupivacaine Clear all

Conditions: Surgery, Analgesia
Interventions: Liposomal bupivacaine, Thoracic epidural analgesia (bupivacaine); Drug · Other
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years and older · Female only
Enrollment: 106 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tibial Fractures
Interventions: Aspiration, Bupivacaine; Procedure · Drug
Lead sponsor: Loyola University; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Knee Osteoarthritis, Knee Rheumatism
Interventions: Obturator nerve regional block, Adductor canal regional block, Saline; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Labor Pain
Interventions: Clonidine, Fentanyl; Drug
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Hip Fracture
Interventions: ultra-sound guide, bupivacaine, morphine; Other · Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 101 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 2
States / cities: Boston, Massachusetts • Worcester, Massachusetts

Conditions: Foot and Ankle Procedures
Interventions: Dexamethasone, Saline; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Upper Eyelid Surgery
Interventions: Hyaluronidase, 2 mL of lidocaine 2% with epinephrine 1:100,000 without rHuPH20; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Post-operative Pain
Interventions: Bupivacaine, Botulinum Toxins, Analgesics; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Pain Assessment, Quality of Life (QOL), Analgesic Use
Interventions: Supplemental Postoperative Bupivacaine, Placebo Injection; Drug
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Cesarean Section Complications, Pain, Opioid Use
Interventions: Liposomal bupivacaine, Bupivacaine Hydrochloride, saline; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Rib Fracture, Rib Fracture Multiple
Interventions: Cryoneurolysis, Local anesthetic peripheral nerve block, Sham Cryoneurolysis, Sham peripheral nerve block; Device · Procedure
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 5
States / cities: La Jolla, California • Bethesda, Maryland • Boston, Massachusetts + 1 more

Conditions: Post-operative Pain, Colon Cancer, Diverticulitis
Interventions: Bupivacaine, Bupivacaine liposome suspension; Drug
Lead sponsor: Des Moines University; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Des Moines, Iowa

Conditions: Total Knee Arthroplasty
Interventions: Liposome Bupivacaine, Bupivacaine; Drug
Lead sponsor: St. Luke's-Roosevelt Hospital Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Stenosing Tenosynovitis
Interventions: Amniotic fluid injection, Steroid injection; Biological
Lead sponsor: J&M Shuler; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Cardiothoracic Surgery
Interventions: Liposomal bupivacaine, 0.25% Bupivacaine with epinephrine; Drug
Lead sponsor: Florida Heart and Lung Institute; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Acute Pain, Atrophic, Goals, Impairment, Infiltration, Injury, Muscle Weakness, Pain, Pathology, Shoulder Pain, Syndrome, Tendinopathy
Interventions: Subacromial injection, Physical Therapy; Procedure · Other
Lead sponsor: University of Oregon; Other
Eligibility: 21 Years to 45 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Colorectal Surgery
Interventions: liposomal Bupivacaine, Bupivacaine Hydrochloride; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Rotator Cuff Tear
Interventions: 0.5% bupivacaine, Normal Saline; Drug
Lead sponsor: Orlando Health, Inc.; Other
Eligibility: 18 Years to 90 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Postoperative Pain
Interventions: EXPAREL, bupivacaine; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 0 Years to 6 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 5
States / cities: Indianapolis, Indiana • St Louis, Missouri • Durham, North Carolina + 2 more

Conditions: Ovarian Cancer, Fibroids, Uterine Cancer
Interventions: Bupivacaine, Liposomal bupivacaine; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Orange, California

Conditions: Congenital Cystic Adenomatoid Malformation
Interventions: Fentanyl; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: Up to 6 Months
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Lumbar Spinal Stenosis
Interventions: physical therapy, lumbar interlaminar epidural steroid injection, epidural steroid injection; Other · Procedure · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Pain, Referred
Interventions: Bupivacaine, Morphine, Fentanyl, Epinephrine, Saline solution; Drug · Other
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 17 Years to 40 Years · Female only
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Pain, Breastfeeding
Interventions: Group 1, Group 2, Group 3; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 345 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery

Intra-articular Local Anesthetic Injection and Hematoma Aspiration

Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?

Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain

Ultrasound Guided Femoral Nerve Block

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery

A Prospective Trial to Reduce Post-Operative Pain in Implant Based Breast Reconstruction

Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment

Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty

Corticosteroid vs. Amniotic Fluid Injections in Patients With Trigger Finger

Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery

Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy

Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery

Post-Op Rotator Cuff Pain Study With Subacromial Bupivacaine Infusion

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures

Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates

Comparison of the Order of Treatment in Lumbar Spinal Stenosis

Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section

The Effect of Neuraxial Analgesia on Maternal Breastfeeding