Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 6, 2026, 4:47 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 841–864 of 975 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Bupivacaine Clear all

Conditions: Readiness to Discharge
Interventions: Peri-Articular Injection, Epidural Pathway (PCEA+FNB); Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 85 Years
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: New York, New York

Conditions: Postoperative Pain Management
Interventions: EXPAREL and Bupivacaine, Standard of Care; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 12
States / cities: New Haven, Connecticut • Boca Raton, Florida • Miami, Florida + 9 more

Conditions: Lumbar Facet Syndrome
Interventions: Cooled Radiofrequency Ablation of Medial Branch Nerves versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome; Procedure
Lead sponsor: University of Utah; Other
Eligibility: 21 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Pain, Postoperative, Total Knee Arthroplasty (TKA)
Interventions: Continuous Femoral Nerve Block, Nerve Block, Continuous Adductor Canal, Continuous Sciatic Nerve Block, Bupivacaine; Procedure · Drug
Lead sponsor: Kevin King, DO; Other
Eligibility: 18 Years to 75 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
Interventions: Bupivicaine intervention arm, Placebo arm; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Injury of Anterior Cruciate Ligament
Interventions: bupivacaine, continuous perineural infusion catheter; Drug · Device
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 14 Years to 18 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Total Hip Arthroplasty
Interventions: PNB Bupivacaine, PAI Ropivacaine, PAI liposomal bupivacaine, Epinephrine, Ketorolac; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Postoperative Pain
Interventions: Exparel plus plain bupivacaine, Bupivacaine; Drug
Lead sponsor: Walter Reed National Military Medical Center; Federal
Eligibility: 18 Years to 120 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Pain, Postoperative
Interventions: Bupivacaine Block, Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Stanford, California

Conditions: Postoperative Pain, Total Knee Arthroplasty, Nerve Block
Interventions: bupivacaine, saline; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 40 Years to 85 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tibial Plateau Fractures
Interventions: Bupivacain; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tibial Plateau Fracture
Interventions: bupivacaine; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Postherpetic Neuralgia, Pain
Interventions: Transdermal/Patch (Bupivacaine TTS [Eladur™]); Drug
Lead sponsor: Durect; Industry
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 7
States / cities: La Jolla, California • Loma Linda, California • Santa Monica, California + 4 more

Conditions: Post-Operative Pain, Pelvic Organ Prolapse
Interventions: Continuous bupivacaine analgesia infusion (ON-Q PainBuster Post-Op Pain Relief System); Device
Lead sponsor: St. Luke's Hospital, Kansas City, Missouri; Other
Eligibility: 18 Years and older · Female only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Postoperative Pain
Interventions: Bupivacaine HCl, SKY0402; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 7
States / cities: Arcadia, California • Laguna Hills, California • Pasadena, California + 3 more

Conditions: Arthroscopic Shoulder Surgery, Intra-articular Debridement, Subacromial Decompression, Acromioplasty, Acromioclavicular Joint Resection
Interventions: Methylprednisolone (40 mg depomedrol, 1ml, injection), Marcaine (4ml 0.5%, injection); Drug
Lead sponsor: Peter Chang; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Sioux Falls, South Dakota

Conditions: Strabismus, Esotropia, Exotropia, Graves Disease, Ptosis, Eyelid
Interventions: Bupivacaine; Drug
Lead sponsor: Smith-Kettlewell Eye Research Institute; Other
Eligibility: 8 Years to 95 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
Interventions: TAP Block, Surgical Site Infiltration, Exparel; Procedure · Drug
Lead sponsor: Danbury Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Danbury, Connecticut

Conditions: Postoperative Pain
Interventions: SKY0402, Bupivacaine HCl; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 4
States / cities: San Clemente, California • Miami, Florida • Houston, Texas + 1 more

Conditions: Postoperative Pain
Interventions: Bupivicaine Infusion; Drug
Lead sponsor: Chang, Steve S., M.D.; Individual
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Santa Barbara, California

Conditions: Total Knee Anthroplasty
Interventions: Intra-articular injection of bupivacaine in the knee joint, intra-articular injection of Exparel in the knee joint, Zynrelef; Drug
Lead sponsor: Foundation for Orthopaedic Research and Education; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
Interventions: Exparel Injectable Product, Bupivacaine Hydrochloride; Drug
Lead sponsor: Kathirvel Subramaniam; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Peritoneal Cancer
Interventions: Local Anesthetic Solution, Bupivacaine HCl, Liposomal Bupivacaine; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Labor Pain
Interventions: Neostigmine, Bupivacaine, fentanyl; Drug
Lead sponsor: Wake Forest University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

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Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade

Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome

Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty

COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block

Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair

Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular

Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy

Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery

US Guided GNB vs Saline Injection for TKA

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

Study of a Bupivacaine Patch (Eladur™) to Treat Post- Herpetic Neuralgia

Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair

Dose-ranging Study for Postoperative Analgesia in Subjects Undergoing Primary Unilateral Inguinal Hernia Repair

Intra-Operative Corticosteroid Injection During Arthroscopic Shoulder Surgery

Bupivacaine Injection of Eye Muscles to Treat Strabismus

Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision

Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy

Bupivicaine to Reduce Postoperative Pain in Laparoscopic Ventral Hernia Repair

Smart Knee Evaluation of Exparel and Zynrelef in TKA Recovery

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

Four Quadrants Transverse Abdominus Plane (4Q-TAP) Block With Plain and Liposomal Bupivacaine vs. Thoracic Epidermal Analgesia (TEA) in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on an Enhanced Recovery Pathway

Epidural Neostigmine for Labor Pain