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ClinicalTrials.gov public records Last synced Nov 6, 2026, 12:52 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 889–912 of 975 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Bupivacaine Clear all

Conditions: Post-operative Pain
Interventions: Bupivacaine, Botulinum Toxins, Analgesics; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Pain, Postoperative
Interventions: Bupivacaine, 0.9% Sodium Chloride; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: ACL, Anterior Cruciate Ligament Injuries
Interventions: Genicular Nerve Block with bupivacaine and preservative free dexamethasone; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Total Knee Replacement, Knee Arthroplasty
Interventions: Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Anesthesia, Pediatrics, Surgery
Interventions: regional nerve block, Antiemetic; Procedure · Drug
Lead sponsor: Indiana University; Other
Eligibility: 1 Year to 18 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Neck Pain
Interventions: Cervical facet joint nerve blocks; Procedure
Lead sponsor: Pain Management Center of Paducah; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Paducah, Kentucky

Conditions: Cardiac Disease
Interventions: Exparel infiltration; Drug
Lead sponsor: Maimonides Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Pain, Postoperative
Interventions: Bupivacaine; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2026
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Rochester, Minnesota

Conditions: Tendonitis
Interventions: Bupivacaine 20mL 0.5%, Bupivacaine 20mL 0.25%, Bupivacaine up to 15mL 0.25%; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Low Back Pain
Interventions: Conventional radiofrequency ablation (RFA), Cooled Radiofrequency Ablation (CRFA); Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 79 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain, Postoperative
Interventions: Local anesthesia at incision site, Sham QL, Sham Local, QL; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Postoperative Pain
Interventions: Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 5
States / cities: Pasadena, California • Orlando, Florida • Houston, Texas + 1 more

Conditions: Pain Management, Sternotomy
Interventions: Exparel, Bupivacaine; Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Analgesia
Interventions: Bupivacaine liposome injectable suspension, Bupivacaine HCl without epinephrine via continuous infusion; Drug
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: Anaheim, California

Conditions: Urinary Incontinence, Stress
Interventions: liposomal bupivacaine, Placebo; Drug
Lead sponsor: TriHealth Inc.; Other
Eligibility: 18 Years and older · Female only
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Total Shoulder Arthroplasty, Shoulder Osteoarthritis
Interventions: Interscalene catheter, Liposomal bupivacaine, Dexamethasone, Bupivacaine; Device · Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 80 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Post Operative Pain, Quality of Recovery After Mastectomy
Interventions: Mastectomy with PECS blocks, Liposomal bupivacaine; Procedure · Drug
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years to 90 Years · Female only
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Lumbar Spinal Stenosis
Interventions: Liposomal bupivacaine; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Postoperative Pain
Interventions: SKY0402 + bupivacaine HCl, Mid-dose SKY0402 + bupivacaine HCl; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Spinal Anesthesia, Epidural; Anesthesia
Interventions: 10 mg Bupivacaine, 5 mg Bupivacaine; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Rhytidoplasty
Interventions: clonidine, glycopyrrolate, propofol, ketamine, marcaine, scopolamine, midazolam, ondansetron, metoclopramide, lidocaine, famotidine, desflurane, sevoflurane; Drug · Device
Lead sponsor: Mercy Facial Plastic Surgery Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Springfield, Missouri

Conditions: Osteoarthritis, Hip
Interventions: isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 84 Years
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 2
States / cities: Bensalem, Pennsylvania • Philadelphia, Pennsylvania

Conditions: Anesthesia, Local
Interventions: Dose adjustment of bupivacaine; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Pain
Interventions: Gabapentin, Diphenhydramine; Drug
Lead sponsor: Michelle Kinney; Other
Eligibility: 45 Years to 75 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Search by objective public record fields.

A Prospective Trial to Reduce Post-Operative Pain in Implant Based Breast Reconstruction

Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.

Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery

Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study

Comparative Study of Superficial Cervical Plexus Block and Nerve of Arnold Block and Incidence of PONV for Inner Ear Surgery

Effectiveness of Cervical Facet Joint Nerve Blocks

Exparel in Minimally Invasive Cardiac Surgery

Exparel Injection for Postoperative Orbital Pain

Pecs II Block Versus Surgeon Infiltration for Open Subpectoral Biceps Tenodesis

A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome

The Role of Quadratus Lumborum Blocks Following Minimally Invasive Hysterectomy

Dose Finding Posterolateral Thoracotomy Study

Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy

Extended Delivery of Bupivacaine Study in Herniorrhaphy

Trial Liposomal Bupivacaine Following Retropubic Suburethral Sling for Stress Urinary Incontinence

Comparison of Analgesic Efficacy Between of Interscalene Block With Liposomal Bupivacaine With Bupivacaine and Dexamethasone

Quality of Recovery From Mastectomy With and Without PECS Blocks

Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine

Evaluation of the Safety and Efficacy of a Single Dose of SKY0402 in Subjects Undergoing Augmentation Mammoplasty

Bupivacaine With Epidural Volume Extension

Anesthetics in Rhytidoplasty - A Comparison Study

3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty

ED50 and ED95 of Isobaric Bupivacaine for Post-Partum Bilateral Tubal Ligation

Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia