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ClinicalTrials.gov public records Last synced Sep 29, 2026, 7:30 AM EDT

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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Bupivacaine 20mL 0.25% Clear all
Active, not recruiting Not applicable Interventional

PENG vs FICB for Hip Fracture in ED Patients

NCT05505604
View directory record Official record
Conditions
Femoral Neck Fractures, Intertrochanteric Fractures
Interventions
PENG, FICB
Procedure
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 29, 2026, 7:30 AM EDT
Suspended Phase 4 Interventional

Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion

NCT03745040
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

NCT04272086
View directory record Official record
Conditions
Fibroid Uterus
Interventions
Bupivacaine, Bupivacaine liposome, normal saline
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 2 Interventional Results available

Liposomal Bupivacaine in Bariatric Surgery

NCT03373591
View directory record Official record
Conditions
Bariatric Surgery Analgesia
Interventions
Liposomal Bupivacaine TAP block, Bupivacaine TAP block
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Not applicable Interventional

PENG vs. FIC Block for Hip Fracture ED Patients

NCT05102760
View directory record Official record
Conditions
Pain, Hip Fracture
Interventions
Nerve Block using FIC Proceedure, Nerve Block using PENG Proceedure
Procedure
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 110 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 29, 2026, 7:30 AM EDT
Not listed Phase 4 Interventional

Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery

NCT04065919
View directory record Official record
Conditions
Cardiothoracic Surgery
Interventions
Liposomal bupivacaine, 0.25% Bupivacaine with epinephrine
Drug
Lead sponsor
Florida Heart and Lung Institute
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Sep 29, 2026, 7:30 AM EDT
Recruiting Phase 4 Interventional

Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy

NCT05224089
View directory record Official record
Conditions
Bowel Disease
Interventions
Liposomal Bupivicaine/Bupivacaine Admixture, Bupivacaine HCL
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 29, 2026, 7:30 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

CMP vs Fascia Iliaca Block

NCT04426058
View directory record Official record
Conditions
Pain, Postoperative, Hip Arthroplasty
Interventions
CMP, Fascia Illica
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Sep 29, 2026, 7:30 AM EDT
Enrolling by invitation Phase 2 Interventional

Hernia Abd Wall Recons - BDE vs Exparel

NCT07518238
View directory record Official record
Conditions
BDE for Hernia Patients, Exparel for Hernia Patients
Interventions
BDE Injectable Drug, Exparel Injectable Drug
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional Results available

Pecs II Block Versus Surgeon Infiltration for Open Subpectoral Biceps Tenodesis

NCT04867369
View directory record Official record
Conditions
Tendonitis
Interventions
Bupivacaine 20mL 0.5%, Bupivacaine 20mL 0.25%, Bupivacaine up to 15mL 0.25%
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 29, 2026, 7:30 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy

NCT02104414
View directory record Official record
Conditions
Hemorrhoid
Interventions
Exparel, Bupivacaine HCl with Epinephrine, Normal Saline
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

NCT05482113
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.25% Inj
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2022 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Early Phase 1 Interventional

LIA in Hip Arthroscopy Patients

NCT03070054
View directory record Official record
Conditions
Pain
Interventions
20ml 0.25% bupivacaine-epinephrine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional Results available

Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction

NCT03700970
View directory record Official record
Conditions
Breast Reconstruction, Anesthesia, Transverse Abdominis Plane Block
Interventions
Liposomal bupivacaine, Regular bupivacaine
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional Results available

PAIN - Postoperative Analgesia INvestigation

NCT02111746
View directory record Official record
Conditions
Postoperative Pain
Interventions
Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery

NCT03196505
View directory record Official record
Conditions
Bariatric Surgery Candidate, Pain, Postoperative
Interventions
Exparel 266 MG Per 20 ML Injection, Bupivacaine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Sep 29, 2026, 7:30 AM EDT
Terminated Phase 3 Interventional

ssTAP vs TAP Catheters in TAH

NCT02525900
View directory record Official record
Conditions
Postoperative Pain
Interventions
Wound Infiltration, TAP Blocks, TAP Catheters
Procedure
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2018 · Synced Sep 29, 2026, 7:30 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery

NCT02741713
View directory record Official record
Conditions
Biceps Tendonitis
Interventions
PECS "Pectoralis" 1 and 2 Blocks, Interscalene Block, Sham Block, Solution for Injection in Interscalene Block, Solution for Injection in Sham Block, Solution for Injection PECS Blocks
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 29, 2026, 7:30 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

NCT06179004
View directory record Official record
Conditions
Distal Radius Fractures, Wrist Fractures
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 29, 2026, 7:30 AM EDT
Completed No phase listed Observational

Impact of Opioid Avoidance Protocol for ACL Reconstruction

NCT06340932
View directory record Official record
Conditions
ACL Tear, Post Operative Pain
Interventions
Iovera, Celecoxib, Acetaminophen, Oxycodone, Tramadol, Bupivacaine Hydrochloride, Acetaminophen 500Mg Cap
Device · Drug
Lead sponsor
Matthew Varacallo
Other
Eligibility
15 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
DuBois, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Sep 29, 2026, 7:30 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Erector Spinae Plane Block vs Erector Spinae Plane Block With Serratus Anterior Plane Block in Thoracic Surgery

NCT04349774
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Control Group - ESP block with SAP block, Treatment Group - ESP block with SAP normal saline
Drug
Lead sponsor
Anna Uskova
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 29, 2026, 7:30 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery

NCT05805423
View directory record Official record
Conditions
Post Operative Pain, Nausea and Vomiting, Postoperative, Opioid Use
Interventions
bilateral superficial cervical plexus blocks and local wound infiltration, placebo injection and local wound infiltration
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 99 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 29, 2026, 7:30 AM EDT
Not listed Phase 3 Interventional

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

NCT02473198
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Exparel, Femoral Nerve Block Bupivacaine, Toradol, Morphine Sulfate
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
18 Years to 73 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 29, 2026, 7:30 AM EDT
Not yet recruiting Not applicable Interventional

Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1

NCT07254650
View directory record Official record
Conditions
Lung Cancer (Diagnosis)
Interventions
Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 29, 2026, 7:30 AM EDT